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Fig. 4 | World Journal of Surgical Oncology

Fig. 4

From: Pathological complete response by advanced hepatocellular carcinoma with massive macrovascular invasion to hepatic arterial infusion chemotherapy: a case report

Fig. 4

Gross and histopathological findings of the resected specimen. Whitish tumor surrounded by omentum at the liver surface (arrow). Background liver was composed of geographical atrophic area and cirrhotic liver parenchyma (a). The cut surface of the tumor shows the solid tumor with significant hemorrhage and necrosis (b). Microscopic finding of the liver mass shows complete necrosis surrounded by a thick hyalinized fibrotic capsule without any viable tumor cells (hematoxylin–eosin staining, × 40) (c). Bilirubin pigments surrounded by necrotic tissue in the central necrotic area (hematoxylin–eosin staining, × 400) (d). Immunohistochemical staining with hepatocyte specific antigen antibody shows nucleated cells in the tumor are negatively stained (× 200) (e), while green dye positive on non-tumorous hepatocyte (× 200) (f)

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