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Table 4 Summary of time points for defining synchronous vs. metachronous and prognostic significance as measured by OS and DFS in publications in 2005–2018

From: Synchronous and metachronous liver metastases in patients with colorectal cancer—towards a clinically relevant definition

Defining time point

Studies (n)

Prognostic value

OS significant

OS non-significant

DFS significant

DFS non-significant

Primary tumour diagnosis/surgery

18

9

9

4

8

Three months post-primary tumour diagnosis/surgery

4

2

2

0

1

Six months post-primary tumour diagnosis/surgery

12

4

8

0

5

Twelve months post-primary tumour diagnosis/surgery

7

0

7

0

1

Total

41

15

26

4

15

  1. OS overall survival, DFS disease-free survival