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Table 4 Summary of time points for defining synchronous vs. metachronous and prognostic significance as measured by OS and DFS in publications in 2005–2018

From: Synchronous and metachronous liver metastases in patients with colorectal cancer—towards a clinically relevant definition

Defining time point Studies (n) Prognostic value
OS significant OS non-significant DFS significant DFS non-significant
Primary tumour diagnosis/surgery 18 9 9 4 8
Three months post-primary tumour diagnosis/surgery 4 2 2 0 1
Six months post-primary tumour diagnosis/surgery 12 4 8 0 5
Twelve months post-primary tumour diagnosis/surgery 7 0 7 0 1
Total 41 15 26 4 15
  1. OS overall survival, DFS disease-free survival