Variable | Necrosis+ | Necrosis | p |
---|---|---|---|
No. of patients | 35 | 23 | Â |
Patient- and tumor-related variables | |||
  Patient age, years |  |  | 0.707 |
    ≤ 60 | 12 (34.3%) | 9 (39.1%) |  |
    > 60 | 23 (65.7%) | 14 (60.9%) |  |
  Gender |  |  | 0.920 |
    Female | 27 (77.1%) | 18 (78.3%) |  |
    Male | 8 (22.9%) | 5 (21.7%) |  |
  Multiple tumor nodules |  |  | 0.587 |
    Positive | 7 (20.0%) | 6 (26.1%) |  |
    Negative | 28 (80.0%) | 17 (73.9%) |  |
  Tumor size, mm |  |  | 0.001 |
    ≤ 50 | 2 (5.7%) | 9 (39.1%) |  |
    > 50 | 33 (94.3%) | 14 (60.9%) |  |
  Angioinvasion |  |  | 0.120 |
    Positive | 21 (60.0%) | 9 (39.1%) |  |
    Negative | 14 (40.0%) | 14 (60.9%) |  |
  Lymphangiosis carcinomatosa |  |  | 0.304 |
    Positive | 12 (34.3%) | 5 (21.7%) |  |
    Negative | 23 (65.7%) | 18 (78.3%) |  |
  Histologic differentiation |  |  | 0.262 |
    Well | 5 (14.3%) | 6 (26.1%) |  |
    Moderate/poor | 30 (85.7%) | 17 (73.9%) |  |
  Pathologic T stage |  |  | 0.038 |
    T1/T2 | 14 (40.0%) | 15 (68.2%) |  |
    T3/T4 | 21 (60.0%) | 8 (31.8%) |  |
  Pathologic N stage |  |  | 0.076 |
    Positive | 0 (00.0%) | 2 (8.7%) |  |
    Negative | 35 (100.0%) | 21 (91.3%) |  |
  TEMs in TCA |  |  | 0.026 |
    Positive | 12 (34.3%) | 2 (8.7%) |  |
    Negative | 23 (65.7%) | 21 (91.3%) |  |
  TEMs in TIF |  |  | 0.402 |
    Positive | 25 (71.4%) | 14 (60.9%) |  |
    Negative | 10 (28.6%) | 9 (39.1%) |  |
  Angiopoietin-1 in TCA |  |  | 0.149 |
    Positive | 3 (8.6%) | 0 (00.0%) |  |
    Negative | 32 (91.4%) | 23 (100.0%) |  |
  Angiopoietin-1 in TIF |  |  | 0.245 |
    Positive | 28 (80.0%) | 21 (91.3%) |  |
    Negative | 7 (20.0%) | 2 (8.7%) |  |
  Angiopoietin-2 in TCA |  |  | 0.818 |
    Positive | 2 (5.7%) | 1 (4.3%) |  |
    Negative | 33 (94.3%) | 22 (95.7%) |  |
  Angiopoietin-2 in TIF |  |  | 0.326 |
    Positive | 1 (2.9%) | 2 (8.7%) |  |
    Negative | 34 (97.1%) | 21 (91.3%) |  |
Operative variables | |||
  R status |  |  | 0.245 |
    Positive | 7 (20.0%) | 2 (8.7%) |  |
    Negative | 28 (80.0%) | 21 (91.3%) |  |
Variables of patient outcome | |||
  Local tumor recurrence |  |  | 0.662 |
    Positive | 11 (31.4%) | 6 (26.1%) |  |
    Negative | 24 (68.6%) | 17 (73.9%) |  |
  Overall tumor recurrence |  |  | 0.087 |
    Positive | 17 (48.6%) | 6 (26.1%) |  |
    Negative | 18 (51.4%) | 17 (73.9%) |  |
  Metastases |  |  | 0.103 |
     Positive | 9 (25.7%) | 2 (8.7%) |  |
    Negative | 26 (74.3%) | 21 (91.3%) |  |