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Fig. 1 | World Journal of Surgical Oncology

Fig. 1

From: BCL2 and hsa-miR-181a-5p are potential biomarkers associated with papillary thyroid cancer based on bioinformatics analysis

Fig. 1

Volcano plot and Venn diagram of DEGs and deregulated miRNAs in gene/miRNA expression profiling datasets. ac Volcano plots of DEGs in normal thyroid tissue and PTC samples in the GSE3467, GSE3678, and GSE33630 datasets. df Venn diagrams illustrating the number of all upregulated and downregulated DEGs in three gene expression datasets. The intersection in the center represents the common DEGs among the three datasets. g, i Volcano plots of deregulated miRNAs in normal thyroid tissue and PTC samples in GSE73182 and GSE113629 datasets, respectively. h Venn diagrams of all deregulated miRNAs in the two datasets. The intersection in the center represents the common deregulated miRNAs between the two datasets. DEGs and deregulated miRNAs were selected by P value < 0.01 and |logFC| > 1. The x-axis shows the fold-change in gene/miRNA expression, and the y-axis shows the statistical significance of the differences. Colors represent different genes/miRNAs: black for genes/miRNAs without significantly different expression, red for significantly upregulated genes/miRNAs and green for significantly downregulated genes/miRNAs. PTC, papillary thyroid cancer; FC, fold change

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