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Table 2 Meta-analyses results of the current study

From: Associations between twelve common gene polymorphisms and susceptibility to hepatocellular carcinoma: evidence from a meta-analysis

Variables Sample size Dominant comparison Recessive comparison Over-dominant comparison Allele comparison
P value OR (95%CI) I2 statistic   P value OR (95%CI) I2 statistic P value OR (95% CI) I2 statistic   P value OR (95%CI) I2 statistic
VDR rs7975232
 Overall 668/894 0.03
60%
1.58 (1.04–2.39) 0.42
31%
0.90 (0.69–1.17) 0.03
44%
0.80 (0.65–0.98) 0.09
76%
1.41 (0.94–2.12)
 East Asian 528/632 0.02
40%
1.39 (1.06–1.81) 0.40
0%
0.88 (0.67–1.17) 0.28
62%
0.75 (0.45–1.26) 0.17
55%
1.30 (0.89–1.89)
VDR rs1544410
 Overall 668/894 0.26
44%
1.15 (0.90–1.45) 0.62
8%
0.93 (0.71–1.22) 0.54
0%
0.93 (0.75–1.16) 0.30
50%
1.09 (0.93–1.27)
 East Asian 528/632 0.98
0%
1.00 (0.74–1.34) 0.91
0%
0.98 (0.75–1.30) 0.90
0%
1.02 (0.79–1.30) 0.96
0%
1.00 (0.83–1.19)
VDR rs2228570
 Overall 805/1088 < 0.0001
46%
1.54 (1.25–1.89) 0.0004
19%
0.67 (0.54–0.84) 0.58
0%
0.95 (0.79–1.14) 0.01
59%
1.34 (1.06–1.68)
 East Asian 725/928 < 0.0001
45%
1.63 (1.31–2.04) 0.0003
40%
0.66 (0.53–0.83) 0.58
0%
0.95 (0.78–1.15) 0.01
65%
1.40 (1.08–1.82)
VDR rs731236
 Overall 668/894 0.06
43%
1.25 (0.99–1.58) 0.26
0%
0.86 (0.66–1.12) 0.42
38%
0.92 (0.74–1.14) 0.06
42%
1.16 (0.99–1.36)
 East Asian 528/632 0.44
57%
1.34 (0.64–2.82) 0.51
0%
0.91 (0.68–1.21) 0.54
66%
0.77 (0.33–1.78) 0.39
55%
1.08 (0.91–1.29)
VEGF rs699947
 Overall 739/886 0.92
54%
1.02 (0.69–1.52) 0.04
0%
0.63 (0.41–0.98) 0.61
45%
0.95 (0.77–1.17) 0.61
51%
1.08 (0.80–1.46)
 East Asian 713/785 0.84
64%
1.05 (0.66–1.66) 0.10
0%
0.67 (0.41–1.08) 0.70
56%
1.08 (0.72–1.65) 0.99
59%
1.00 (0.70–1.42)
VEGF rs1570360
 Overall 293/336 0.12
37%
1.31 (0.93–1.85) 0.57
19%
0.75 (0.29–1.98) 0.17
7%
0.78 (0.55–1.11) 0.13
49%
1.26 (0.94–1.70)
 East Asian 191/209 0.28
60%
1.49 (0.72–3.06) 0.24
0%
0.27 (0.03–2.41) 0.15
44%
0.71 (0.45–1.13) 0.28
64%
1.46 (0.73–2.91)
VEGF rs2010963
 Overall 715/871 0.79
55%
1.05 (0.72–1.54) 0.26
0%
1.17 (0.89–1.55) 0.80
48%
0.97 (0.80–1.19) 0.32
13%
0.93 (0.81–1.07)
 East Asian 715/871 0.79
55%
1.05 (0.72–1.54) 0.26
0%
1.17 (0.89–1.55) 0.80
48%
0.97 (0.80–1.19) 0.32
13%
0.93 (0.81–1.07)
VEGF rs3025039
 Overall 994/970 0.08
12%
1.20 (0.98–1.48) 0.08
38%
0.50 (0.23–1.09) 0.21
0%
0.87 (0.71–1.08) 0.05
28%
1.21 (1.00–1.46)
 East Asian 568/625 0.10
0%
1.24 (0.96–1.59) 0.87
69%
0.83 (0.09–7.41) 0.25
0%
0.86 (0.66–1.11) 0.06
34%
1.24 (0.99–1.56)
IL-18 rs187238
 Overall 1653/2594 0.38
85%
1.19 (0.81–1.77) 0.50
16%
1.14 (0.78–1.66) 0.26
88%
0.77 (0.49–1.21) 0.56
78%
1.09 (0.82–1.43)
 East Asian 1180/2022 0.62
81%
1.11 (0.73–1.70) 0.27
33%
1.33 (0.80–2.22) 0.49
81%
0.86 (0.55–1.34) 0.76
78%
1.06 (0.74–1.50)
 South Asian 361/370 0.60
97%
1.70 (0.24–12.29) 0.65
0%
1.19 (0.57–2.47) 0.53
98%
0.45 (0.04–5.35) 0.69
92%
1.25 (0.42–3.66)
 HBV 881/1443 0.90
78%
1.03 (0.65–1.63) 0.23
43%
1.38 (0.81–2.33) 0.73
78%
0.92 (0.57–1.48) 0.96
74%
1.01 (0.70–1.46)
IL18 rs1946518
 Overall 1599/2045 0.002
0%
0.79 (0.68–0.92) 0.004
30%
1.26 (1.08–1.48) 0.75
0%
1.02 (0.90–1.17) 0.002
59%
0.78 (0.67–0.91)
 East Asian 1126/1464 0.09
0%
0.86 (0.71–1.02) 0.15
0%
1.14 (0.95–1.37) 0.79
0%
1.02 (0.87–1.19) 0.04
68%
0.80 (0.65–0.99)
 South Asian 589/679 0.001
0%
0.66 (0.51–0.85) 0.02
0%
1.57 (1.09–2.27) 0.98
54%
0.99 (0.61–1.61) 0.002
0%
0.72 (0.59–0.89)
 HBV 827/885 0.01
9%
0.77 (0.62–0.95 0.06
21%
1.25 (0.99–1.57) 0.52
0%
1.06 (0.88–1.29) 0.03
73%
0.73 (0.55–0.96)
MBL rs7096206
 Overall 931/821 < 0.0001 0.59 (0.48–0.73) 0%   0.37
70%
1.81 (0.50–6.59) < 0.0001
0%
1.59 (1.28–1.97) < 0.0001 0% 0.63 (0.53–0.76)
 East Asian 869/706 < 0.0001
0%
0.62 (0.50–0.78) 0.35
79%
2.08 (0.44–9.80) 0.0005
0%
1.50 (1.19–1.88) < 0.0001 4% 0.65 (0.53–0.79)
MBL rs1800450
 Overall 857/650 0.85
79%
0.95 (0.58–1.55) 0.91
77%
1.06 (0.37–3.06) 0.70
75%
1.10 (0.69–1.74) 0.95
80%
0.99 (0.65–1.50)
 East Asian 642/486 0.99
90%
0.99 (0.44–2.23) 0.61
81%
1.47 (0.34–6.30) 0.99
86%
1.00 (0.49–2.03) 0.95
90%
0.98 (0.48–1.99)
  1. Abbreviations: OR odds ratio, CI confidence interval, NA not available, HBV hepatitis B virus infection
  2. The values in italics represent that there is statistically significant differences between cases and controls