Table 2 Meta-analyses results of the current study
Variables | Sample size | Dominant comparison | Recessive comparison | Over-dominant comparison | Allele comparison | ||||
|---|---|---|---|---|---|---|---|---|---|
P value OR (95%CI) I2 statistic | Â | P value | OR (95%CI) I2 statistic | P value OR (95% CI) I2 statistic | Â | P value | OR (95%CI) I2 statistic | ||
VDR rs7975232 | |||||||||
 Overall | 668/894 | 0.03 60% | 1.58 (1.04–2.39) | 0.42 31% | 0.90 (0.69–1.17) | 0.03 44% | 0.80 (0.65–0.98) | 0.09 76% | 1.41 (0.94–2.12) |
 East Asian | 528/632 | 0.02 40% | 1.39 (1.06–1.81) | 0.40 0% | 0.88 (0.67–1.17) | 0.28 62% | 0.75 (0.45–1.26) | 0.17 55% | 1.30 (0.89–1.89) |
VDR rs1544410 | |||||||||
 Overall | 668/894 | 0.26 44% | 1.15 (0.90–1.45) | 0.62 8% | 0.93 (0.71–1.22) | 0.54 0% | 0.93 (0.75–1.16) | 0.30 50% | 1.09 (0.93–1.27) |
 East Asian | 528/632 | 0.98 0% | 1.00 (0.74–1.34) | 0.91 0% | 0.98 (0.75–1.30) | 0.90 0% | 1.02 (0.79–1.30) | 0.96 0% | 1.00 (0.83–1.19) |
VDR rs2228570 | |||||||||
 Overall | 805/1088 | < 0.0001 46% | 1.54 (1.25–1.89) | 0.0004 19% | 0.67 (0.54–0.84) | 0.58 0% | 0.95 (0.79–1.14) | 0.01 59% | 1.34 (1.06–1.68) |
 East Asian | 725/928 | < 0.0001 45% | 1.63 (1.31–2.04) | 0.0003 40% | 0.66 (0.53–0.83) | 0.58 0% | 0.95 (0.78–1.15) | 0.01 65% | 1.40 (1.08–1.82) |
VDR rs731236 | |||||||||
 Overall | 668/894 | 0.06 43% | 1.25 (0.99–1.58) | 0.26 0% | 0.86 (0.66–1.12) | 0.42 38% | 0.92 (0.74–1.14) | 0.06 42% | 1.16 (0.99–1.36) |
 East Asian | 528/632 | 0.44 57% | 1.34 (0.64–2.82) | 0.51 0% | 0.91 (0.68–1.21) | 0.54 66% | 0.77 (0.33–1.78) | 0.39 55% | 1.08 (0.91–1.29) |
VEGF rs699947 | |||||||||
 Overall | 739/886 | 0.92 54% | 1.02 (0.69–1.52) | 0.04 0% | 0.63 (0.41–0.98) | 0.61 45% | 0.95 (0.77–1.17) | 0.61 51% | 1.08 (0.80–1.46) |
 East Asian | 713/785 | 0.84 64% | 1.05 (0.66–1.66) | 0.10 0% | 0.67 (0.41–1.08) | 0.70 56% | 1.08 (0.72–1.65) | 0.99 59% | 1.00 (0.70–1.42) |
VEGF rs1570360 | |||||||||
 Overall | 293/336 | 0.12 37% | 1.31 (0.93–1.85) | 0.57 19% | 0.75 (0.29–1.98) | 0.17 7% | 0.78 (0.55–1.11) | 0.13 49% | 1.26 (0.94–1.70) |
 East Asian | 191/209 | 0.28 60% | 1.49 (0.72–3.06) | 0.24 0% | 0.27 (0.03–2.41) | 0.15 44% | 0.71 (0.45–1.13) | 0.28 64% | 1.46 (0.73–2.91) |
VEGF rs2010963 | |||||||||
 Overall | 715/871 | 0.79 55% | 1.05 (0.72–1.54) | 0.26 0% | 1.17 (0.89–1.55) | 0.80 48% | 0.97 (0.80–1.19) | 0.32 13% | 0.93 (0.81–1.07) |
 East Asian | 715/871 | 0.79 55% | 1.05 (0.72–1.54) | 0.26 0% | 1.17 (0.89–1.55) | 0.80 48% | 0.97 (0.80–1.19) | 0.32 13% | 0.93 (0.81–1.07) |
VEGF rs3025039 | |||||||||
 Overall | 994/970 | 0.08 12% | 1.20 (0.98–1.48) | 0.08 38% | 0.50 (0.23–1.09) | 0.21 0% | 0.87 (0.71–1.08) | 0.05 28% | 1.21 (1.00–1.46) |
 East Asian | 568/625 | 0.10 0% | 1.24 (0.96–1.59) | 0.87 69% | 0.83 (0.09–7.41) | 0.25 0% | 0.86 (0.66–1.11) | 0.06 34% | 1.24 (0.99–1.56) |
IL-18 rs187238 | |||||||||
 Overall | 1653/2594 | 0.38 85% | 1.19 (0.81–1.77) | 0.50 16% | 1.14 (0.78–1.66) | 0.26 88% | 0.77 (0.49–1.21) | 0.56 78% | 1.09 (0.82–1.43) |
 East Asian | 1180/2022 | 0.62 81% | 1.11 (0.73–1.70) | 0.27 33% | 1.33 (0.80–2.22) | 0.49 81% | 0.86 (0.55–1.34) | 0.76 78% | 1.06 (0.74–1.50) |
 South Asian | 361/370 | 0.60 97% | 1.70 (0.24–12.29) | 0.65 0% | 1.19 (0.57–2.47) | 0.53 98% | 0.45 (0.04–5.35) | 0.69 92% | 1.25 (0.42–3.66) |
 HBV | 881/1443 | 0.90 78% | 1.03 (0.65–1.63) | 0.23 43% | 1.38 (0.81–2.33) | 0.73 78% | 0.92 (0.57–1.48) | 0.96 74% | 1.01 (0.70–1.46) |
IL18 rs1946518 | |||||||||
 Overall | 1599/2045 | 0.002 0% | 0.79 (0.68–0.92) | 0.004 30% | 1.26 (1.08–1.48) | 0.75 0% | 1.02 (0.90–1.17) | 0.002 59% | 0.78 (0.67–0.91) |
 East Asian | 1126/1464 | 0.09 0% | 0.86 (0.71–1.02) | 0.15 0% | 1.14 (0.95–1.37) | 0.79 0% | 1.02 (0.87–1.19) | 0.04 68% | 0.80 (0.65–0.99) |
 South Asian | 589/679 | 0.001 0% | 0.66 (0.51–0.85) | 0.02 0% | 1.57 (1.09–2.27) | 0.98 54% | 0.99 (0.61–1.61) | 0.002 0% | 0.72 (0.59–0.89) |
 HBV | 827/885 | 0.01 9% | 0.77 (0.62–0.95 | 0.06 21% | 1.25 (0.99–1.57) | 0.52 0% | 1.06 (0.88–1.29) | 0.03 73% | 0.73 (0.55–0.96) |
MBL rs7096206 | |||||||||
 Overall | 931/821 | < 0.0001 0.59 (0.48–0.73) 0% |  | 0.37 70% | 1.81 (0.50–6.59) | < 0.0001 0% | 1.59 (1.28–1.97) | < 0.0001 0% | 0.63 (0.53–0.76) |
 East Asian | 869/706 | < 0.0001 0% | 0.62 (0.50–0.78) | 0.35 79% | 2.08 (0.44–9.80) | 0.0005 0% | 1.50 (1.19–1.88) | < 0.0001 4% | 0.65 (0.53–0.79) |
MBL rs1800450 | |||||||||
 Overall | 857/650 | 0.85 79% | 0.95 (0.58–1.55) | 0.91 77% | 1.06 (0.37–3.06) | 0.70 75% | 1.10 (0.69–1.74) | 0.95 80% | 0.99 (0.65–1.50) |
 East Asian | 642/486 | 0.99 90% | 0.99 (0.44–2.23) | 0.61 81% | 1.47 (0.34–6.30) | 0.99 86% | 1.00 (0.49–2.03) | 0.95 90% | 0.98 (0.48–1.99) |