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Table 1 The characteristics of included studies for this meta-analysis

From: Associations between twelve common gene polymorphisms and susceptibility to hepatocellular carcinoma: evidence from a meta-analysis

First author, year Country Ethnicity Type of disease Medical history of patients Sample size
Case/control
Genotype distribution
(wtwt/wtmt/mtmt)
P value for HWE NOS score
Cases controls
VDR rs7975232
 Barooah 2019 [11] India South Asian HCC NA 60/102 49/11/0 59/35/8 0.391 8
 Falleti 2010 [12] Italy Caucasian HCC Viral hepatitis 87% 80/160 27/38/15 53/85/22 0.189 8
 Hung 2014 [13] Taiwan East Asian HCC NA 92/100 65/24/3 55/40/5 0.505 8
 Yao 2013 [16] China East Asian HCC HBV 100%, alcohol intake 34.9% 436/532 112/216/108 114/275/143 0.395 8
VDR rs1544410
 Barooah 2019 [11] India South Asian HCC NA 60/102 52/8/0 80/16/6 < 0.001 8
 Falleti 2010 [12] Italy Caucasian HCC Viral hepatitis 87% 80/160 33/35/12 45/87/28 0.206 8
 Hung 2014 [13] Taiwan East Asian HCC NA 92/100 85/7/0 89/11/0 0.560 8
 Yao 2013 [16] China East Asian HCC HBV 100%, alcohol intake 34.9% 436/532 112/217/107 142/259/131 0.550 8
VDR rs2228570
 Falleti 2010 [12] Italy Caucasian HCC Viral hepatitis 87% 80/160 36/36/8 69/73/18 0.843 8
 Liu 2015 [14] China East Asian HCC NA 105/100 41/44/20 23/48/29 0.715 8
 Peng 2014 [15] China East Asian HCC HBV 100%, alcohol intake 90.2% 184/296 54/90/40 77/152/67 0.628 8
 Yao 2013 [16] China East Asian HCC HBV 100%, alcohol intake 34.9% 436/532 131/198/107 102/241/189 0.111 8
VDR rs731236
 Barooah 2019 [11] India South Asian HCC NA 60/102 48/8/4 71/21/10 <0.001 8
 Falleti 2010 [12] Italy Caucasian HCC Viral hepatitis 87% 80/160 32/38/10 44/88/28 0.160 8
 Hung 2014 [13] Taiwan East Asian HCC NA 92/100 86/6/0 86/14/0 0.452 8
 Yao 2013 [16] China East Asian HCC HBV 100%, alcohol intake 34.9% 436/532 115/212/109 137/252/143 0.226 8
VEGF rs699947
 Liu 2017 [19] China East Asian HCC HBV 60.2%, alcohol intake 60.8% 476/526 301/157/18 290/202/34 0.882 8
 Machado 2014 [20] Portugal Caucasian HCC Alcohol intake 100% 26/101 7/14/5 19/49/33 0.914 7
 Ratnasari 2017 [22] Indonesia East Asian HCC HBV58%, HCV 11% 44/59 18/21/5 23/30/6 0.402 7
 Wu 2009 [23] China East Asian HCC NA 92/90 48/40/4 58/28/4 0.792 8
 Wu 2013 [24] China East Asian HCC HBV48.5% 101/110 79/21/1 91/17/2 0.271 8
VEGF rs1570360
 Baitello 2016 [17] Canada Mixed HCC HBV 50%, HCV 21%, alcohol intake 56% 102/127 61/35/6 73/47/7 0.875 8
 Wu 2009 [23] China East Asian HCC NA 90/99 66/24/0 72/27/0 0.116 8
 Wu 2013 [24] China East Asian HCC HBV48.5% 101/110 83/17/1 75/31/4 0.723 8
VEGF rs2010963
 Liu 2017 [19] China East Asian HCC HBV 60.2%, alcohol intake 60.8% 476/526 162/232/82 200/248/78 0.937 8
 Ratnasari 2016 [21] Indonesia East Asian HCC HBV56.5%, HCV 10.8% 46/136 16/29/1 26/105/5 <0.001 7
 Wu 2009 [23] China East Asian HCC NA 92/99 34/40/18 34/52/13 0.320 8
 Wu 2013 [24] China East Asian HCC HBV48.5% 101/110 28/52/21 35/51/24 0.506 8
VEGF rs3025039
 Baitello 2016 [17] Canada Mixed HCC HBV 50%, HCV 21%, alcohol intake 56% 102/127 72/30/0 90/37/0 0.055 8
 Giacalone 2011 [18] Italy Caucasian HCC NA 96/162 81/14/1 120/38/4 0.636 8
 Liu 2017 [19] China East Asian HCC HBV 60.2%, alcohol intake 60.8% 476/526 359/112/5 370/140/16 0.536 8
 Wu 2009 [23] China East Asian HCC NA 92/99 63/26/3 68/30/1 0.239 8
 Yvamoto 2015 [25] Brazil Mixed HCC Alcohol intake 47.1% 228/56 164/64/0 43/13/0 0.326 7
IL-18 rs187238
 Bakr 2018 [26] Egypt South Asian HCC HCV 100% 90/90 66/22/2 33/65/1 <0.001 8
 Bao 2015 [27] China East Asian HCC HBV 100% 153/165 122/28/3 106/54/5 0.548 8
 Chen 2012 [28] China East Asian HCC NA 228/300 159/59/10 173/115/12 0.183 7
 Dai 2017 [29] China East Asian HCC HBV 100%, alcohol intake 42% 245/250 187/49/9 183/65/2 0.142 8
 Karra 2015 [30] India South Asian HCC HBV 100% 271/280 123/134/14 159/108/13 0.320 7
 Kim 2009 [31] Korea East Asian HCC HBV 100% 56/558 37/17/2 434/122/2 0.031 7
 Lau 2016 [32] Taiwan East Asian HCC Alcohol intake 63.5% 342/559 266/73/3 476/78/5 0.370 8
 Migita 2009 [33] Japan East Asian HCC HBV 100% 47/63 43/3/1 52/10/1 0.531 7
 Teixeira 2009 [34] Brazil Mixed HCC Viral hepatitis 67.8%, alcohol intake 63.4% 112/202 57/48/7 100/84/18 0.952 7
 Zhang 2016 [35] China East Asian HCC HBV 100% 109/127 82/25/2 99/24/4 0.110 8
IL18 rs1946518
 Bakr 2018 [26] Egypt South Asian HCC HCV 100% 90/99 13/34/43 17/45/37 0.603 8
 Bao 2015 [27] China East Asian HCC HBV 100% 153/165 37/73/43 41/76/48 0.322 8
 Chen 2012 [28] China East Asian HCC NA 228/300 47/126/55 83/156/61 0.429 7
 Dai 2017 [29] China East Asian HCC HBV 100%, alcohol intake 42% 247/250 62/118/67 64/124/62 0.900 8
 Karra 2015 [30] India South Asian HCC HBV 100% 271/280 70/152/49 102/144/34 0.119 7
 Lau 2016 [32] Taiwan East Asian HCC Alcohol intake 63.5% 342/559 88/167/87 148/276/135 0.777 8
 Migita 2009 [33] Japan East Asian HCC HBV 100% 47/63 13/26/8 20/30/13 0.777 7
 Teixeira 2009 [34] Brazil Mixed HCC Viral hepatitis 67.8%, alcohol intake 63.4% 112/202 38/56/18 85/105/12 0.202 7
 Zhang 2016 [35] China East Asian HCC HBV 100% 109/127 22/55/32 38/66/23 0.127 8
MBL rs7096206
 Eurich 2011 [36] Germany Caucasian HCC NA 62/115 27/34/1 76/37/2 0.292 7
 Gu 2016 [37] China East Asian HCC NA 334/171 232/95/7 131/33/7 0.015 8
 Lin 2015 [38] China East Asian HCC Alcohol intake 77.7% 220/220 125/86/9 153/65/2 0.082 8
 Su 2016 [40] China East Asian HCC HBV 70.2% 315/315 207/91/17 239/72/4 0.583 8
MBL rs1800450     NA      
 Gu 2016 [37] China East Asian HCC NA 334/171 234/89/11 104/59/8 0.920 8
 Segat 2008 [39] Italy Caucasian HCC NA 215/164 127/78/10 102/49/13 0.050 7
 Su 2016 [40] China East Asian HCC HBV 70.2% 308/315 208/88/20 239/69/7 0.450 8
  1. Abbreviations: HWE Hardy-Weinberg equilibrium, NOS Newcastle-Ottawa scale, NA not available, HBV hepatitis B virus infection, HCV hepatitis C virus infection