Table 1 The characteristics of included studies for this meta-analysis
First author, year | Country | Ethnicity | Type of disease | Medical history of patients | Sample size Case/control | Genotype distribution (wtwt/wtmt/mtmt) | P value for HWE | NOS score | |
|---|---|---|---|---|---|---|---|---|---|
Cases controls | |||||||||
VDR rs7975232 | |||||||||
 Barooah 2019 [11] | India | South Asian | HCC | NA | 60/102 | 49/11/0 | 59/35/8 | 0.391 | 8 |
 Falleti 2010 [12] | Italy | Caucasian | HCC | Viral hepatitis 87% | 80/160 | 27/38/15 | 53/85/22 | 0.189 | 8 |
 Hung 2014 [13] | Taiwan | East Asian | HCC | NA | 92/100 | 65/24/3 | 55/40/5 | 0.505 | 8 |
 Yao 2013 [16] | China | East Asian | HCC | HBV 100%, alcohol intake 34.9% | 436/532 | 112/216/108 | 114/275/143 | 0.395 | 8 |
VDR rs1544410 | |||||||||
 Barooah 2019 [11] | India | South Asian | HCC | NA | 60/102 | 52/8/0 | 80/16/6 | < 0.001 | 8 |
 Falleti 2010 [12] | Italy | Caucasian | HCC | Viral hepatitis 87% | 80/160 | 33/35/12 | 45/87/28 | 0.206 | 8 |
 Hung 2014 [13] | Taiwan | East Asian | HCC | NA | 92/100 | 85/7/0 | 89/11/0 | 0.560 | 8 |
 Yao 2013 [16] | China | East Asian | HCC | HBV 100%, alcohol intake 34.9% | 436/532 | 112/217/107 | 142/259/131 | 0.550 | 8 |
VDR rs2228570 | |||||||||
 Falleti 2010 [12] | Italy | Caucasian | HCC | Viral hepatitis 87% | 80/160 | 36/36/8 | 69/73/18 | 0.843 | 8 |
 Liu 2015 [14] | China | East Asian | HCC | NA | 105/100 | 41/44/20 | 23/48/29 | 0.715 | 8 |
 Peng 2014 [15] | China | East Asian | HCC | HBV 100%, alcohol intake 90.2% | 184/296 | 54/90/40 | 77/152/67 | 0.628 | 8 |
 Yao 2013 [16] | China | East Asian | HCC | HBV 100%, alcohol intake 34.9% | 436/532 | 131/198/107 | 102/241/189 | 0.111 | 8 |
VDR rs731236 | |||||||||
 Barooah 2019 [11] | India | South Asian | HCC | NA | 60/102 | 48/8/4 | 71/21/10 | <0.001 | 8 |
 Falleti 2010 [12] | Italy | Caucasian | HCC | Viral hepatitis 87% | 80/160 | 32/38/10 | 44/88/28 | 0.160 | 8 |
 Hung 2014 [13] | Taiwan | East Asian | HCC | NA | 92/100 | 86/6/0 | 86/14/0 | 0.452 | 8 |
 Yao 2013 [16] | China | East Asian | HCC | HBV 100%, alcohol intake 34.9% | 436/532 | 115/212/109 | 137/252/143 | 0.226 | 8 |
VEGF rs699947 | |||||||||
 Liu 2017 [19] | China | East Asian | HCC | HBV 60.2%, alcohol intake 60.8% | 476/526 | 301/157/18 | 290/202/34 | 0.882 | 8 |
 Machado 2014 [20] | Portugal | Caucasian | HCC | Alcohol intake 100% | 26/101 | 7/14/5 | 19/49/33 | 0.914 | 7 |
 Ratnasari 2017 [22] | Indonesia | East Asian | HCC | HBV58%, HCV 11% | 44/59 | 18/21/5 | 23/30/6 | 0.402 | 7 |
 Wu 2009 [23] | China | East Asian | HCC | NA | 92/90 | 48/40/4 | 58/28/4 | 0.792 | 8 |
 Wu 2013 [24] | China | East Asian | HCC | HBV48.5% | 101/110 | 79/21/1 | 91/17/2 | 0.271 | 8 |
VEGF rs1570360 | |||||||||
 Baitello 2016 [17] | Canada | Mixed | HCC | HBV 50%, HCV 21%, alcohol intake 56% | 102/127 | 61/35/6 | 73/47/7 | 0.875 | 8 |
 Wu 2009 [23] | China | East Asian | HCC | NA | 90/99 | 66/24/0 | 72/27/0 | 0.116 | 8 |
 Wu 2013 [24] | China | East Asian | HCC | HBV48.5% | 101/110 | 83/17/1 | 75/31/4 | 0.723 | 8 |
VEGF rs2010963 | |||||||||
 Liu 2017 [19] | China | East Asian | HCC | HBV 60.2%, alcohol intake 60.8% | 476/526 | 162/232/82 | 200/248/78 | 0.937 | 8 |
 Ratnasari 2016 [21] | Indonesia | East Asian | HCC | HBV56.5%, HCV 10.8% | 46/136 | 16/29/1 | 26/105/5 | <0.001 | 7 |
 Wu 2009 [23] | China | East Asian | HCC | NA | 92/99 | 34/40/18 | 34/52/13 | 0.320 | 8 |
 Wu 2013 [24] | China | East Asian | HCC | HBV48.5% | 101/110 | 28/52/21 | 35/51/24 | 0.506 | 8 |
VEGF rs3025039 | |||||||||
 Baitello 2016 [17] | Canada | Mixed | HCC | HBV 50%, HCV 21%, alcohol intake 56% | 102/127 | 72/30/0 | 90/37/0 | 0.055 | 8 |
 Giacalone 2011 [18] | Italy | Caucasian | HCC | NA | 96/162 | 81/14/1 | 120/38/4 | 0.636 | 8 |
 Liu 2017 [19] | China | East Asian | HCC | HBV 60.2%, alcohol intake 60.8% | 476/526 | 359/112/5 | 370/140/16 | 0.536 | 8 |
 Wu 2009 [23] | China | East Asian | HCC | NA | 92/99 | 63/26/3 | 68/30/1 | 0.239 | 8 |
 Yvamoto 2015 [25] | Brazil | Mixed | HCC | Alcohol intake 47.1% | 228/56 | 164/64/0 | 43/13/0 | 0.326 | 7 |
IL-18 rs187238 | |||||||||
 Bakr 2018 [26] | Egypt | South Asian | HCC | HCV 100% | 90/90 | 66/22/2 | 33/65/1 | <0.001 | 8 |
 Bao 2015 [27] | China | East Asian | HCC | HBV 100% | 153/165 | 122/28/3 | 106/54/5 | 0.548 | 8 |
 Chen 2012 [28] | China | East Asian | HCC | NA | 228/300 | 159/59/10 | 173/115/12 | 0.183 | 7 |
 Dai 2017 [29] | China | East Asian | HCC | HBV 100%, alcohol intake 42% | 245/250 | 187/49/9 | 183/65/2 | 0.142 | 8 |
 Karra 2015 [30] | India | South Asian | HCC | HBV 100% | 271/280 | 123/134/14 | 159/108/13 | 0.320 | 7 |
 Kim 2009 [31] | Korea | East Asian | HCC | HBV 100% | 56/558 | 37/17/2 | 434/122/2 | 0.031 | 7 |
 Lau 2016 [32] | Taiwan | East Asian | HCC | Alcohol intake 63.5% | 342/559 | 266/73/3 | 476/78/5 | 0.370 | 8 |
 Migita 2009 [33] | Japan | East Asian | HCC | HBV 100% | 47/63 | 43/3/1 | 52/10/1 | 0.531 | 7 |
 Teixeira 2009 [34] | Brazil | Mixed | HCC | Viral hepatitis 67.8%, alcohol intake 63.4% | 112/202 | 57/48/7 | 100/84/18 | 0.952 | 7 |
 Zhang 2016 [35] | China | East Asian | HCC | HBV 100% | 109/127 | 82/25/2 | 99/24/4 | 0.110 | 8 |
IL18 rs1946518 | |||||||||
 Bakr 2018 [26] | Egypt | South Asian | HCC | HCV 100% | 90/99 | 13/34/43 | 17/45/37 | 0.603 | 8 |
 Bao 2015 [27] | China | East Asian | HCC | HBV 100% | 153/165 | 37/73/43 | 41/76/48 | 0.322 | 8 |
 Chen 2012 [28] | China | East Asian | HCC | NA | 228/300 | 47/126/55 | 83/156/61 | 0.429 | 7 |
 Dai 2017 [29] | China | East Asian | HCC | HBV 100%, alcohol intake 42% | 247/250 | 62/118/67 | 64/124/62 | 0.900 | 8 |
 Karra 2015 [30] | India | South Asian | HCC | HBV 100% | 271/280 | 70/152/49 | 102/144/34 | 0.119 | 7 |
 Lau 2016 [32] | Taiwan | East Asian | HCC | Alcohol intake 63.5% | 342/559 | 88/167/87 | 148/276/135 | 0.777 | 8 |
 Migita 2009 [33] | Japan | East Asian | HCC | HBV 100% | 47/63 | 13/26/8 | 20/30/13 | 0.777 | 7 |
 Teixeira 2009 [34] | Brazil | Mixed | HCC | Viral hepatitis 67.8%, alcohol intake 63.4% | 112/202 | 38/56/18 | 85/105/12 | 0.202 | 7 |
 Zhang 2016 [35] | China | East Asian | HCC | HBV 100% | 109/127 | 22/55/32 | 38/66/23 | 0.127 | 8 |
MBL rs7096206 | |||||||||
 Eurich 2011 [36] | Germany | Caucasian | HCC | NA | 62/115 | 27/34/1 | 76/37/2 | 0.292 | 7 |
 Gu 2016 [37] | China | East Asian | HCC | NA | 334/171 | 232/95/7 | 131/33/7 | 0.015 | 8 |
 Lin 2015 [38] | China | East Asian | HCC | Alcohol intake 77.7% | 220/220 | 125/86/9 | 153/65/2 | 0.082 | 8 |
 Su 2016 [40] | China | East Asian | HCC | HBV 70.2% | 315/315 | 207/91/17 | 239/72/4 | 0.583 | 8 |
MBL rs1800450 | Â | Â | Â | NA | Â | Â | Â | Â | Â |
 Gu 2016 [37] | China | East Asian | HCC | NA | 334/171 | 234/89/11 | 104/59/8 | 0.920 | 8 |
 Segat 2008 [39] | Italy | Caucasian | HCC | NA | 215/164 | 127/78/10 | 102/49/13 | 0.050 | 7 |
 Su 2016 [40] | China | East Asian | HCC | HBV 70.2% | 308/315 | 208/88/20 | 239/69/7 | 0.450 | 8 |