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Table 2 Univariate and multivariate analysis for variables associated with DFS

From: Association of pre-surgery to pre-radiotherapy lymphocyte counts ratio with disease-free survival in rectal cancer patients receiving neoadjuvant concurrent chemoradiotherapy

Clinical factors

Univariate analysis

Multivariable analysis

HR

95% CI

p

HR

95% CI

p

Age

(≥ 59 vs< 59)

0.935

0.338–3.255

1.048

   

Sex

(F vs M)

0.428

0.093–1.980

0.278

   

CEA

(≥ 5.0 vs < 5.0)

0.980

0.315–3.049

0.972

  

Downstage

(n vs y)

2.104

0.459–9.653

0.338

   

N status

(N+ vs N−)

1.924

0.610–6.07

0.264

   

Pre-SL

(L vs H)

3.363

0.987–13.656

0.052

   

Pre-RTL

(L vs H)

0.433

0.095–1.983

0.281

   

Lnadir

(L vs H)

1.804

0.542–6.003

0.336

   

Pre-SLR

(L vs H)

6.287

1.374–28.781

0.018

7.347

1.595–33.850

0.011

  1. HR, hazard ratio; CI, confidence interval; F, female; M, male; CEA, carcino-embryonic antigen; N, lymph node; N+, lymph node positive; N−, lymph node negative; pre-SL, absolute lymphocyte counts before surgery; pre-RTL, absolute lymphocyte counts before concurrent chemoradiotherapy; Lnadir, the lowest absolute lymphocyte count during concurrent chemoradiotherapy; n, no; y, yes; L, low; H, high