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Table 4 Mutational analysis of all study subjects

From: Mutational spectrum of tobacco associated oral squamous carcinoma and its therapeutic significance

S. No.MutationsCytogenetic locationCodon no.VariantVariant typeSite
1TP5317p13.1Codon 72c.215C>G
(Pro72Arg)
Mis-sense
Transversion
Buccal mucosa
2TP5317p13.1Codon 72c.215C>G
(Pro72Arg)
Mis-sense
Transversion
Buccal mucosa
3TP5317p13.1Codon 72c.215C>G
(Pro72Arg)
Mis-sense
Transversion
Tongue
4TP5317p13.1Codon 72c.215C>G
(Pro72Arg)
Mis-sense
Transversion
Tongue
5TP5317p13.1Codon 72c.215C>G
(Pro72Arg)
Mis-sense
Transversion
Buccal mucosa
6TP5317p13.1Codon 152c.455C>T
(Pro152Leu)
Mis-sense
Transition
Lower alveolus
7TP5317p13.1Codon 158c.472C>T
(Arg158Cys)
Mis-sense
Transition
Tongue
8TP5317p13.1Codon 165c.493C>T
(Gln165Ter)
Non-senseTongue
9TP5317p13.1Codon 173c.517G>A
(Val173Met)
Mis-sense
Transition
Tongue
10TP5317p13.1Codon 175c.524G>A
(Arg175His)
Mis-sense
Transition
Buccal mucosa
11TP5317p13.1Codon 204c.610G>T
(Glu204Ter)
Non-senseBuccal mucosa
12TP5317p13.1Codon 213c.638G>A
(Arg213Gln)
Mis-sense
Transition
Buccal mucosa
13TP5317p13.1Codon 241c.722C>T
(Ser241Phe)
Mis-sense
Transition
Lower alveolus
14TP5317p13.1Codon 244c.731G>C
(Gly244Ala)
Mis-sense
Transversion
Buccal mucosa
15TP5317p13.1Codon 248c.742C>T
(Arg248Trp)
Mis-sense
Transition
Buccal mucosa
16TP5317p13.1Codon 248c.742C>T
(Arg248Trp)
Mis-sense
Transition
Tongue
17TP5317p13.1Codon 248c.743G>A
(Arg248Gln)
Mis-sense
Transition
Buccal mucosa
18TP5317p13.1Codon 267c.799C>T
(Arg267Tryp)
Mis-sense
Transition
Tongue
19TP5317p13.1Codon 274c.820G>T
(Val274Phe)
Mis-sense
Tranversion
Lower alveolus
20TP5317p13.1Codon 274c.821T>G
(Val274Gly)
Mis-sense
Transversion
Buccal mucosa
21TP5317p13.1Codon 301c.902delC (pro301Glnfs)Deletion (frameshift)Tongue
22TP5317p13.1Codon 306c.916C>T
(Arg306Ter)
Non-senseBuccal mucosa
23TP5317p13.1Codon 306c.916C>T
(Arg306Ter)
Non-senseUpper alveolus
24TP5317p13.1-c.376-1G>A
unknown
Intron variant
(splice site)
Buccal mucosa
25CDKN2A9p21.3Codon78c.233-234delTC
(Leu78fs)
Deletion
(frameshift)
Buccal mucosa
26CDKN2A9p21.3Codon 80c.238 C>T
(Arg80Ter)
Non-senseBuccal mucosa
27CDKN2A9p21.3Codon 80c.238 C>T
(Arg80Ter)
Non-senseBuccal mucosa
28CDKN2A9p21.3Codon 80c.238C>T
(Arg80Ter)
Non-senseBuccal mucosa
29CDKN2A9p21.3Codon 80c.238C>T
(Arg80Ter)
Non-senseTongue
30CDKN2A9p21.3Codon 80c.238C>T
(Arg80Ter)
Non-senseLower alveolus
31CDKN2A9p21.3Codon 80c.238C>T
(Arg80Ter)
Non-senseTongue
32CDKN2A9p21.3Codon 110c.330G>A
(Trp110Ter)
Non-senseBuccal mucosa
33CDKN2A9p21.3Codon 110c.330G>A
(Trp110Ter)
Non-senseBuccal mucosa
34CDKN2A9p21.3Codon 110c.330G>A
(Trp110Ter)
Non-senseUpper alveolus
35HRAS11p15.5Codon 12c.34G>A
(Gly12Ser)
Mis-sense
Transition
Buccal mucosa
36HRAS11p15.5Codon 12c.34G>A
(Gly12Ser)
Mis-sense
Transition
Buccal mucosa
37HRAS11p15.5Codon 12c.34G>A
(Gly12Ser)
Mis-sense
Transition
Buccal mucosa
38HRAS11p15.5Codon 12c.35G>A
(Gly12Asp)
Mis-sense
Transition
Lower lip
39HRAS11p15.5Codon 13c.37G>C
(Gly13Arg)
Mis-sense
Transversion
Lower lip
40HRAS11p15.5Codon 13c.38G>T
(Gly13Val)
Mis-sense
Transversion
Buccal mucosa
41HRAS11p15.5Codon 61c.181C>A
(Gln61Lys)
Mis-sense
Transversion
Tongue
42HRAS11p15.5Codon 61c.182A>T
(Gln61Leu)
Mis-sense
Transversion
Tongue
43PIK3CA3q26.32Codon 542c.1625A>C
(Glu542Ala)
Mis-sense
Transversion
Lower alveolus
44PIK3CA3q26.3Codon 542c.1624G>A
(Glu542Lys)
Mis-sense
Transition
Lower alveolus
45PIK3CA3q26.3Codon 1047c.3140 A>G
(His1047Arg)
Mis-sense
Transition
Buccal mucosa
46SMARCB122q11.23-c.1146-41G>A
unknown
Intron variantBuccal mucosa
47SMARCB122q11.23-c.1146-41G>AIntron variantBuccal mucosa
48KIT4q12Codon 541c.1621A>C
(Met541Leu)
Mis-sense
Transversion
Buccal mucosa
49BRAF7q34Codon 466c.1397G>C
(Gly466Ala)
Mis-sense
Transversion
Lower alveolus
50STK1119p13.3Codon 357c.1071G>T
(Glu357Asp)
Mis-sense
Transversion
Lower alveolus
51ABL19q34.12Codon 274c.764A>T
(Glu274Val)
Mis-sense
Transversion
Tongue
Codon 415c.1187A>G
(His415Pro)
Mis-sense
Transition
52EGFR7p11.2Codon 746c.2234delAGG (Glu746del)Deletion
(in frame
Deletion)
Tongue
53RB113q14.2Codon 680c.2039T>C
(Ile680Thr)
Mis-sense
Transition
Tongue