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Table 1 Clinical and histopathological findings

From: Mutational spectrum of tobacco associated oral squamous carcinoma and its therapeutic significance

Clinical findingsFrequencyPercent
Site of tumor  
 Tongue1328.3
 Buccal Mucosa2452.2
 Lower Alveolus613.0
 Upper Alveolus12.20
 Lip24.30
Side  
 Right1839.1
 Left2656.5
 Midline12.20
 Crossing midline12.20
Number lesion  
 Single4495.70
 Multiple24.30
Clinical size of tumor (cm)*  
 ≥ 41941.30
 < 42758.70
Extension to adjacent site  
 Yes1737
 No2963
T status  
 T22350.00
 T3817.40
 T41532.60
Clinical nodes  
 No1532.60
 N11737.00
 N21328.30
 N312.20
Stage  
 II1737.00
 III1123.90
 IVa1737.00
 IVb12.20
Comorbid factors  
 Yes817.40
 No3882.60
ECOG performance status  
 0919.60
 13780.40
Imaging
 CT size (cm)  
  < 41328.30
  ≥ 43371.70
Neck node present2247.80
 Involved adjacent site  
  Bone919.60
  Skin510.90
  Muscle919.60
TNM stage (CT)  
 II1123.90
 III1737.00
 IVa1737.00
 IVb12.00
Neck dissection
 SOHND2247.80
 MRND1737.00
 None715.20
Surgical reconstruction
 None1634.80
 Pectoralis major myocutaneous flap1430.40
 Nasolabial flap1328.30
 Buccal pad of fat24.30
 Sternocleidomastoid flap12.20
 Total46100.0
Histopathological findings
 HPE grade  
  I (well differentiated)2247.80
  II (moderately differentiated)2247.80
  III (poorly differentiated)24.30
T size (cm)  
 ≥ 41123.90
 < 43576.10
Positive margin24.30
Lymphovascular invasion1328.30
Perineural invasion2043.50
Depth of invasion (mm)  
 < 548.70
 ≥ 5 to < 102452.20
 ≥ 101839.10
Pathological stage  
 I12.20
 II2247.80
 III715.20
 IVa1328.30
 IVb36.50
Mutations
 TP531941.3
 CDKN2A1123.9
 HRAS817.4
 PIK3CA36.5
 SMARCB124.3
 KIT12.2
 EGFR12.2
 BRAF12.2
 STK1112.2
 ABL112.2
 RB112.2
 NRAS00.0
 KRAS00.0
  1. *The largest numeric value of length, breadth, and depth had been considered