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Table 1 Clinical and histopathological findings

From: Mutational spectrum of tobacco associated oral squamous carcinoma and its therapeutic significance

Clinical findings

Frequency

Percent

Site of tumor

  

 Tongue

13

28.3

 Buccal Mucosa

24

52.2

 Lower Alveolus

6

13.0

 Upper Alveolus

1

2.20

 Lip

2

4.30

Side

  

 Right

18

39.1

 Left

26

56.5

 Midline

1

2.20

 Crossing midline

1

2.20

Number lesion

  

 Single

44

95.70

 Multiple

2

4.30

Clinical size of tumor (cm)*

  

 ≥ 4

19

41.30

 < 4

27

58.70

Extension to adjacent site

  

 Yes

17

37

 No

29

63

T status

  

 T2

23

50.00

 T3

8

17.40

 T4

15

32.60

Clinical nodes

  

 No

15

32.60

 N1

17

37.00

 N2

13

28.30

 N3

1

2.20

Stage

  

 II

17

37.00

 III

11

23.90

 IVa

17

37.00

 IVb

1

2.20

Comorbid factors

  

 Yes

8

17.40

 No

38

82.60

ECOG performance status

  

 0

9

19.60

 1

37

80.40

Imaging

 CT size (cm)

  

  < 4

13

28.30

  ≥ 4

33

71.70

Neck node present

22

47.80

 Involved adjacent site

  

  Bone

9

19.60

  Skin

5

10.90

  Muscle

9

19.60

TNM stage (CT)

  

 II

11

23.90

 III

17

37.00

 IVa

17

37.00

 IVb

1

2.00

Neck dissection

 SOHND

22

47.80

 MRND

17

37.00

 None

7

15.20

Surgical reconstruction

 None

16

34.80

 Pectoralis major myocutaneous flap

14

30.40

 Nasolabial flap

13

28.30

 Buccal pad of fat

2

4.30

 Sternocleidomastoid flap

1

2.20

 Total

46

100.0

Histopathological findings

 HPE grade

  

  I (well differentiated)

22

47.80

  II (moderately differentiated)

22

47.80

  III (poorly differentiated)

2

4.30

T size (cm)

  

 ≥ 4

11

23.90

 < 4

35

76.10

Positive margin

2

4.30

Lymphovascular invasion

13

28.30

Perineural invasion

20

43.50

Depth of invasion (mm)

  

 < 5

4

8.70

 ≥ 5 to < 10

24

52.20

 ≥ 10

18

39.10

Pathological stage

  

 I

1

2.20

 II

22

47.80

 III

7

15.20

 IVa

13

28.30

 IVb

3

6.50

Mutations

 TP53

19

41.3

 CDKN2A

11

23.9

 HRAS

8

17.4

 PIK3CA

3

6.5

 SMARCB1

2

4.3

 KIT

1

2.2

 EGFR

1

2.2

 BRAF

1

2.2

 STK11

1

2.2

 ABL1

1

2.2

 RB1

1

2.2

 NRAS

0

0.0

 KRAS

0

0.0

  1. *The largest numeric value of length, breadth, and depth had been considered