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Table 1 Prognostic factor analysis in 120 patients with lung cancer metastases to the spine

From: Modified score based on revised Tokuhashi score is needed for the determination of surgical intervention in patients with lung cancer metastases to the spine

Prognostic factorn*Kaplan–MeierUnivariate COX regressionMultivariate Cox regression
Median OSΔpHR (95% CI)pHR (95% CI) p
Gender
 Female4912     
 Male7160.12461.346 (0.910–1.991)0.136  
Age
 ≤ 66.5 years7910     
 > 66.5 years4160.29531.226 (0.828–1.814)0.309  
History of smoking
 With908     
 Without3070.60741.115 (0.727–1.712)0.618  
Tumor marker
 Normal4117     
 Abnormal796< 0.00012.557 (1.639–3.992)0.0002.526 (1.620–3.937)0.000
ESR
 Normal5511     
 Abnormal6560.75431.061 (0.726–1.551)0.761  
ALP
 Normal728     
 Abnormal4880.47941.147 (0.777–1.696)0.490  
LDH
 Normal6112     
 Abnormal5960.08151.386 (0.949–2.023)0.091  
Albumin
 Normal5310     
 Abnormal676.60.61891.098 (0.752–1.605)0.628  
Calcium ion
 Normal807     
 Abnormal40100.32860.822 (0.549–1.231)0.342  
Neoplasms histologic type of lung cancer
 Adenocarcinoma979.5     
 Others2350.51511.165 (0.725–1.872)0.528  
The adoption of targeted therapy
 With4817     
 Without725.65< 0.00012.231 (1.487–3.347)0.0002.207 (1.471–3.310)0.000
The adoption of bisphosphonates
With3613     
Without8460.03551.533 (1.015–2.315)0.0420.904 (0.563–1.451)0.676
Initial diagnosis because of spinal metastasis or not
 No396     
 Yes8190.90790.977 (0.656–1.455)0.910  
Adoption of adjuvant treatment (including chemotherapy or radiation therapy)
With6510     
Without5570.25841.237 (0.846–1.806)0.272  
  1. *Number of patients
  2. ΔMedian overall survival (mo)
  3. Hazard ratio (95% CI)
  4. OS, overall survival; HR, hazard ratio; CI, confidence interval; ESR, erythrocyte sedimentation rate; ALP, alkaline phosphatase; LDH, lactic dehydrogenase