Fig. 6

The macroscopic and pathological findings of the resected tumor. Arrows showing the irregular elevated mucosa with an ulcerated lesion of the resected tumor (a). The pathological examination of the resected tumor revealed that the ulcerated lesion had inflammatory granulation tissue but did not contain invasive carcinoma (b) (hematoxylin and eosin). Many consecutive intraepithelial micropapillary lesions spread around the ulcerated lesion (arrows), and the epithelial cells showed an increased nucleus-to-cytoplasm ratio, nuclear hyperchromasia, and architectural atypia (c) (hematoxylin and eosin, × 200). The pathological diagnosis was BilIN-1 to -2. Immunohistochemical staining showed that S100P was slightly expressed in the cytoplasm and MUC5AC was positive. MUC1 was negative and p53 was not overexpressed (d S100P, e MUC1, f MUC5AC, g p53) (× 200)