Fig. 2

Jigsaw-like destructive infiltration of the submucosa by a mixture of pale appearing histiocytes, some cytologically atypical lymphocytes, and eosinophils; overview (H&E staining, × 100). Bottom left: detail magnification with centroblastoid and immunoblastoid large cells (H&E staining, × 360). Bottom right: positivity for CD5 of the smaller and larger lymphocytes in the lesion (immunoperoxidase staining, × 240)