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Table 1 Clinical characteristics of stage I to III endometrial cancer patients stratified by lymph node status

From: Cervical invasion, lymphovascular space invasion, and ovarian metastasis as predictors of lymph node metastasis and poor outcome on stages I to III endometrial cancers: a single-center retrospective study

CharacteristicsTotal N = 874LNMP value
No
N = 792 (90.62)
Yes
N = 82 (9.38)
Age at surgery (years)53.58 ± 0.4053.74 ± 0.4251.79 ± 1.530.24
Pathological type0.01
 Endometrioid760 (86.96)702 (88.64)58 (70.73) 
 Non-endometroid114 (13.04)90 (11.36)24 (29.27)
FIGO stage< 0.01
 I570 (65.22)570 (71.97)0 
 II212 (24.26)212 (26.77)0
 III92 (10.52)10 (1.26)82 (100)
Tumor grade0.04
 1240 (27.46)224 (28.28)16 (19.51) 
 2438 (50.14)398 (50.25)34 (41.46)
 3196 (22.40)170 (21.57)32 (39.03)
Myometrial invasion< 0.01
 < 50%586 (67.05)548 (69.19)38 (46.34) 
 ≥ 50%288 (32.95)244 (30.81)44 (53.66)
Primary tumor diameter0.26
 < 2100 (11.44)96 (12.12)4 (4.88) 
 ≥ 2774 (88.36)696 (87.88)78 (95.12)
Cervical stromal invasion< 0.01
 No604 (69.11)576 (72.73)28 (34.15)
 Yes270 (30.89)216 (27.17)54 (65.85) 
LVSI< 0.01
 No736 (84.21)716 (90.40)48 (58.54) 
 Yes138 (15.79)76 (9.60)34 (41.46)
Ascites0.49
 No736 (84.21)670 (84.60)66 (80.49) 
 Yes138 (15.79)122 (15.40)16 (19.51)
Ovarian metastasis< 0.01
 No850 (97.25)782 (98.74)68 (82.93) 
 Yes24 (2.75)10 (1.26)14 (17.07)
Preoperative CA12524.45 (27.70)23.19 (26.52)41.53 (56.46)< 0.01
Lymphadenectomy0.61
 Only pelvic530 (60.64)478 (60.35)52 (63.41) 
 Pelvic + paraaortic320 (36.61)294 (37.12)26 (31.71)
 Paraaortic sampling24 (2.75)20 (2.53)4 (4.88)
Median number of LNs removed, n (range)13 (10–65)13 (10–65)13 (10–33)0.83
 Number of pelvic LNs removed13 (10–46)13 (10–46)11 (10–33)0.17
 Number of paraoartic LNs removed3 (0–23)3 (0–23)3 (0–11)0.11
Lymph node metastasis 
 Pelvic LN metastasis only74 (90.24)
 PALN metastasis only  0
 Pelvic and PALN metastasis  8 (9.76)
Status< 0.01
 Alive790 (90.39)748 (94.44)42 (51.22) 
 Died84 (9.61)44 (5.56)40 (48.78)
 Follow-up, month (range)59.3 (5–108.5)59.5 (5–108.5)56.6 (8.3–108)0.96
Adjuvant therapy0.03
 No748 (85.58)690 (87.12)58 (70.73) 
Chemotherapy only94 (10.76)74 (9.34)20 (24.39)
Radiotherapy only28 (3.20)24 (3.03)4 (4.88)
Both4 (0.46)4 (0.51)0
  1. LVSI lymphovascular space invasion, FIGO international federation of gynecology and obstetrics. Values for continuous variables are mean ± standard deviation. Values for categorical variables are number (percentage). LNs lymph nodes, PALN para-aortic lymph node
  2. A P value < 0.05 was considered to be statistically significant