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Table 5 Multivariate analysis to identify the prognostic factors for recurrence in rectal adenocarcinoma

From: Factors predicting recurrence after curative resection for rectal cancer: a 16-year study

Prognostic factors Risk category Reference category Multivariate analysis
HR 95% CI p
Factors related to the population
 Sex Female Male 1.356 0.5–3.3 0.50
 Age < 50 years ≥ 50 years 0.429 0.1–1.0 0.07
Factors related to the tumor
 Stenotic character Stenotic Non-stenotic 4.387 1.2–15.2 0.02
 Size ≥ 5 cm < 5 cm 0.710 0.2–1.7 0.45
Factors related to adjuvant and neoadjuvant treatment
 Neoadjuvant radiochemotherapy Absent Present 1.502 0.6–3.3 0.32
Factors related to surgery
 Surgical intervention Abdominoperineal resection Anterior resection of the rectum 1.216 0.4–3.1 0.69
 Distal margin ≤ 2 cm > 2 cm 6.819 2.7–16.6 0.00
 Intraoperative incident Yes No 1.627 0.2–9.0 0.57
Pathological factors
 Parietal invasion (pT stage) T3–T4 T1–T2 3.073 1.1–9.4 0.05
 Perforated character of the tumor Yes No 2.279 0.1–33.6 0.54
 Ganglionic invasion (pN stage) Yes No 0.300 0–6.7 0.44
 Extra capsular invasion Yes No 4.408 1.3–14.0 0.01
 Vascular emboli Yes No 1.398 0.5–3.4 0.47
 lymphatic and perineural invasion Yes No 2.369 0.7–7.0 0.12
 pTNM stage III and IV I and II 4.623 0.2–90.9 0.31
  1. HR hazard ratio, CI confidence interval