Over-expression of Nav1.6 channels is associated with lymph node metastases in colorectal cancer

Table 4 Analysis of the correlation between the upregulation of lymph node metastasis-related molecular markers and lymph node metastasis in colorectal cancer (CRC) tissues

Gene	Lymph node metastasis CRC	Non-Lymph node metastasis CRC	T	P
hCCR2	4.21 ± 3.67	2.24 ± 2.12	2.949	0.005
hTGFbetaR	0.94 ± 0.54	0.91 ± 0.55	0.215	0.830
hCD3e	2.65 ± 1.52	2.52 ± 2.12	0.304	0.762
hCCR4	3.40 ± 3.50	2.03 ± 1.85	2.168	0.035
hP53	2.23 ± 1.5 2	2.33 ± 1.59	− 0.305	0.761
hCCR7	6.21 ± 5.56	6.44 ± 6.65	− 0.172	0.864
hBcl2	2.41 ± 1.45	2.14 ± 1.50	0.883	0.380
h1L2Ra	6.45 ± 5.13	4.68 ± 3.65	1.973	0.051
hCD8a	11.55 ± 8.95	11.21 ± 12.49	0.144	0.886

Two-tailed t test in SPSS20.0 was used to determine whether lymph node metastasis was a group variable, and the expression of each immune factor was a test variable. When the sig value of the Levene test is greater than 0.05, the T value and the P value are obtained by assuming the variance is equal. When the sig value of the Levene test is less than 0.05, the T value and the P value are obtained by assuming that the variances are not equal. P < 0.05 is marked in italic

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