Over-expression of Nav1.6 channels is associated with lymph node metastases in colorectal cancer

Table 3 Two-tailed t test analysis of the correlation between the upregulation of different sodium channel subtypes and lymphovascular invasion in CRC tissues

Nav subtype	Lymphovascular invasion	Non-lymphovascular invasion	T	P
Nav1.1	2.70 ± 2.90	2.31 ± 1.98	0.791	0.431
Nav1.2	1.58 ± 1.38	2.32 ± 2.48	− 1.874	0.064
Nav1.3	0.40 ± 0.51	0.37 ± 0.49	0.232	0.817
Nav1.4	2.79 ± 2.84	2.36 ± 2.25	0.831	0.408
Nav1.5	1.41 ± 1.38	1.30 ± 1.18	0.399	0.691
Nav1.6	3.83 ± 3.15	1.86 ± 1.68	3.639	0.001
Nav1.7	2.60 ± 2.58	1.57 ± 1.85	2.287	0.024
Nav1.8	3.15 ± 2.68	2.50 ± 1.88	1.405	0.163
Nav1.9	1.41 ± 1.30	2.06 ± 1.78	− 1.959	0.053

The independent sample t test in SPSS20.0 was used to determine whether lymph node metastasis was a grouping variable, and the expression of the sodium ion channel subtype was a test variable. When the sig value of the Levene test is greater than 0.05, the T value and the P value are obtained by assuming the variance is equal. When the sig value of the Levene test is less than 0.05, the T value and the P value are obtained by assuming that the variances are not equal. An obtained P value of < 0.05 is indicated in italic

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