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Fig. 1 | World Journal of Surgical Oncology

Fig. 1

From: Over-expression of Nav1.6 channels is associated with lymph node metastases in colorectal cancer

Fig. 1

CRC sampling and lymph node metastasis detection. a The tissue removed via surgery for CRC radical resection, including the intestine approximately 25 cm from the anus, the corresponding total mesorectal and sigmoid mesenteric tissue, the inferior mesenteric artery, and the surrounding lymph node tissue. The tumor was round with an ulcerated diameter of approximately 3.5–4 cm (marked with red arrow). b is a 10 × 10-fold hematoxylin and eosin (HE) staining map of a non-metastatic lymph node, and its cellular structure and cell size are not significantly abnormal. c represents an HE staining map of a metastatic lymph node. d is a collective statistical analysis of lymph node metastasis and clinicopathological parameters from 97 CRC patients. For colon cancer, the resection range includes colon-centered, 10-cm upper and lower colon tissue and the corresponding mesenteric and mesenteric root tissues; for rectal cancer, the resected tissue includes tumor-centered proximal 10 cm, down 2–5 cm (depending on the location of the tumor from the anus and whether the anus is retained) and the corresponding mesenteric and mesenteric root tissues. All lymph nodes in the tissue were searched postoperatively and their metastases were counted

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