High expression of FABP4 and FABP6 in patients with colorectal cancer

Table 1 Comparison of clinical parameters and biochemical indicators between CRC group and control group [(\( \overline{x} \) ± s, n (%)]

Variable	CRC group (n = 100)		P^a value	Control group (n = 100)	P^b value
Variable	Before surgery	After surgery	P^a value	Control group (n = 100)	P^b value
Age (years)	55.50 ± 8.87	55.50 ± 8.87	NS	53.31 ± 10.58	NS
Sex
Male	64 (64)	64 (64)	NS	36 (36)	NS
Female	53 (53)	53 (53)		47 (47)
Smokers
Current	21 (21)	21 (21)	NS	30 (30)	NS
Ex	10 (10)	10 (10)	NS	7 (7)	NS
Alcohol	40 (40)	40 (40)	NS	33 (33)	NS
NSAIDs	16 (16)	16 (16)	NS	10 (10)	NS
Diabetes	6	6	NS	5	NS
Family history of CRC	7 (7)	7 (7)	NS	1 (1)	0.030
BMI (kg/m²)	23.49 ± 2.73	23.42 ± 2.66	NS	22.81 ± 2.78	NS
WC (cm)	84.8 ± 8.6	84.6 ± 8.7	NS	83.5 ± 7.5	0.236
WHR	0.89 ± 0.07	0.89 ± 0.09	NS	0.87 ± 0.07	0.043
SBP (mmHg)	127 ± 16	126 ± 17	NS	128 ± 20	0.940
DBP (mmHg)	79 ± 11	80 ± 12	NS	82 ± 13	0.055
TCH (mmol/L)	4.77 ± 0.92	4.79 ± 0.89	NS	4.37 ± 0.90	0.003
TG (mmol/L)	1.59 ± 0.95	1.57 ± 0.87	NS	1.46 ± 0.80	0.287
LDL-C (mmol/L)	2.89 ± 0.97	2.88 ± 0.93	NS	2.53 ± 0.50	0.001
HDL-C (mmol/L)	1.17 ± 0.49	1.16 ± 0.52	NS	1.65 ± 0.14	0.006
FPG (mmol/L)	6.17 ± 4.45	6.34 ± 4.72	NS	5.50 ± 1.16	NS
FABP4 (pg/ml)	302.24 ± 56.58	268.08 ± 33.92	< 0.001	191.97 ± 53.49	< 0.001
FABP6 (pg/ml)	411.86 ± 83.25	354.64 ± 41.79	< 0.001	289.66 ± 48.57	< 0.001
CEA (ng/ml)	8.88 ± 1.26	6.72 ± 1.32	0.029	5.08 ± 0.81	0.001
CA-199 (U/ml)	14.50 ± 3.39	12.40 ± 4.36	0.048	11.02 ± 2.41	0.004

Abbreviations: NSAID non-steroid anti-inflammatory drug, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, WC waist circumference, WHR waist:hip ratio, TCH total cholesterol, TG triglyceride, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, FPG fasting plasma glucose, FABP4 fatty acid-binding proteins 4, FABP6 fatty acid-binding proteins 6, CEA carcinoembryonic, CA19-9 carbohydrate antigen 19-9, NS non-significant Intergroup comparisions, P^a after surgery vs before surgery, P^b control group vs CRC group before surgery)

ISSN: 1477-7819