Role and limitation of neoadjuvant hepatic arterial infusion chemotherapy in advanced hepatocelluar carcinoma patients with Child-Pugh class A

Table 4 Prognostic factors associated with overall survival of HAIC

Risk factors	Univariate	Multivariate
Risk factors	P value	HR (95% CI)	P value
Age (years)	0.123
Gender	0.870
Total bilirubin (mg/dL)	0.033	1.312 (0.943–1.825)	0.108
Platelet (× 10³/mL)	0.342
Albumin (g/dL)	0.556
PT (%)	0.153
AFP (ng/mL)	0.446
PIVKA-II (m AU/mL)	0.205
Tumor size	0.446
Tumor number	0.105
Previous locoregional treatment	0.528
PVTT	0.407
Extrahepatic metastasis	0.595
HAIC cycle	0.119
Liver resection after HAIC	0.001	3.480 (1.587-7.630)	0.002

HAIC hepatic arterial infusion chemotherapy, HR hazard ratio, CI, confidence interval, PT prothrombin time, AFP alpha-fetoprotein, PIVKA-II proteins induced by vitamin K antagonist-II, PVTT portal vein tumor thrombus, ORR objective response rate

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