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Table 4 Univariate and multivariate analyses of predictors of overall survival

From: High-Mobility Group Box 1 expression predicts survival of patients after resection of adenocarcinoma of the ampulla of Vater

Univariate analysis

   

Multivariate analysis

 

Variable

HR

95% CI

P value

HR

95% CI

P value

Age (60 ≤)

0.62

0.26–1.50

0.29

–

–

–

Sex (male)

1.40

0.61–3.22

0.42

–

–

–

Type of pancreatectomy (PD)

1.43

0.63–3.22

0.39

–

–

–

Node dissection (D1)

1.87

0.83–4.23

0.19

–

–

–

Operative time (480 min ≤)

0.97

0.42–2.20

0.93

–

–

–

Blood loss (800 ml ≤)

3.46

1.28–9.34

0.014

1.88

0.60–5.91

0.28

Transfusion (yes)

3.21

1.44–7.17

0.004

3.13

1.26–7.78

0.014

Morbidity (grade IIIa)

0.98

0.44–2.19

0.96

–

–

–

Tumor diameter (20 mm ≤)

1.12

0.47–2.65

0.80

–

–

–

Histological type (moderate or poor)

1.93

0.86–4.32

0.11

–

–

–

T stage (T2, T3a)

2.57

1.05–6.25

0.038

1.31

0.47–3.63

0.60

N stage (N1, N2)

9.12

3.53–23.57

< 0.001

7.43

2.83–19.54

< 0.001

HMGB1 expression (High)

2.48

1.09–5.66

0.030

3.54

1.37–9.16

0.009

Adjuvant chemotherapy (−)

0.70

0.30–1.64

0.42

–

–

–