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Table 3 Relationships between HMGB1 expression and clinicopathological factors

From: High-Mobility Group Box 1 expression predicts survival of patients after resection of adenocarcinoma of the ampulla of Vater

Variable HMGB1 high (n = 31) HMGB1 low (n = 48) P value
Age
 Median (range) 68 (46–83) 66 (42–83) 0.42
Sex
 Male 11 (35%) 24 (50%) 0.21
 Female 20 (65%) 24 (50%)  
Type of pancreatectomy
 PD 23 (74%) 22 (46%) 0.013
 PpPD, SSPPD 8 (26%) 26 (54%)  
Node dissection
 D1 12 (39%) 12 (25%) 0.20
 D2, D3 19 (61%) 36 (75%)  
Operative time (min)
 Median (range) 490 (308–716) 451 (0–856) 0.3
Blood loss (ml)
 Median (range) 949 (150–3696) 722 (100–3020) 0.025
Transfusion
 Yes 8 (26%) 11 (23%) 0.77
 No 23 (74%) 37 (77%)  
Morbidity (grade IIIa)
 Yes 13 (42%) 22 (46%) 0.73
 No 18 (58%) 26 (54%)  
Tumor diameter (mm)
 Median (range) 20 (8–35) 20 (8–65) 0.074
Tumor ulceration
 Yes 9 (29%) 13 (27%) 0.85
 No 22 (71%) 35 (73%)  
Type of adenocarcinoma
 Moderate or poor differentiated 12 (39%) 21 (44%) 0.66
 Other types 19 (61%) 27 (56%)  
T stage (AJCC 8th)
 T3a 9 (29%) 18 (38%) 0.44
 T1a, T1b, T2 22 (71%) 30 (62%)  
N stage (AJCC 8th)
 N1, N2 12 (39%) 14 (29%) 0.38
 N0 19 (61%) 34 (71%)  
Overall stage (AJCC 8th)
 IIA, IIIA, IIIB 17 (55%) 24 (50%) 0.67
 IA, IB 14 (45%) 24 (50%)  
Adjuvant chemotherapy
 (−) 20 (65%) 31 (65%) 1.00
 (+) 11 (35%) 17 (35%)