P.R.O.P.S. — A novel Pre-Operative Predictive Score for unresectability in patients with colorectal peritoneal metastases being considered for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)

Table 4 Development of PROPS with multivariate analysis

Variables	Beta-coefficient	Score	OR (95% CI)	P value
Poor tumour biology
Suboptimal resection	1.0	1	0.17 (0.05–0.63)	0.01
Multiple lines of chemotherapy	1.0	1	0.18 (0.03–0.94)	0.07
High grade tumour	1.0	1	0.16 (0.04–0.68)	0.03
Heavy tumour burden
Bloatedness	2.5	2	0.16 (0.04–0.58)	0.01
Palpable abdominal mass	2.5	2	0.01 (0.00–0.24)	< 0.01
CT ascites	2.5	2	0.02 (0.00–0.33)	< 0.01
CT omental thickening	2.5	2	0.01 (0.00–0.17)	< 0.01
CT small bowel disease	2.5	2	0.14 (0.02–0.78)	0.05
Active tumour proliferation
Elevated tumour markers	2.0	2	0.10 (0.01–0.84)	0.03

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