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Table 4 Development of PROPS with multivariate analysis

From: P.R.O.P.S. — A novel Pre-Operative Predictive Score for unresectability in patients with colorectal peritoneal metastases being considered for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)

Variables Beta-coefficient Score OR (95% CI) P value
Poor tumour biology
 Suboptimal resection 1.0 1 0.17 (0.05–0.63) 0.01
 Multiple lines of chemotherapy 1.0 1 0.18 (0.03–0.94) 0.07
 High grade tumour 1.0 1 0.16 (0.04–0.68) 0.03
Heavy tumour burden
 Bloatedness 2.5 2 0.16 (0.04–0.58) 0.01
 Palpable abdominal mass 2.5 2 0.01 (0.00–0.24) < 0.01
 CT ascites 2.5 2 0.02 (0.00–0.33) < 0.01
 CT omental thickening 2.5 2 0.01 (0.00–0.17) < 0.01
 CT small bowel disease 2.5 2 0.14 (0.02–0.78) 0.05
Active tumour proliferation
 Elevated tumour markers 2.0 2 0.10 (0.01–0.84) 0.03