Table 1 Patient characteristics and results of univariate analysis of factors predicting febrile neutropenia

 Age (years)

66.5

58.0

67.0

0.032

 Sex (male/ female)

79/13

17/3

62/10

n.s.

 PS (0/1/2)

71/19/2

16/3/1

55/16/1

n.s.

 Alcohol (yes/no)

83/9

18/2

65/7

n.s.

 Smoking (yes/no)

79/13

17/3

62/10

n.s.

 Brinkman index (< 600/≥ 600)

40/52

6/14

34/38

n.s.

 Malignancy

83/9

19/1

64/8

n.s.

 Use of pegfilgrastim (yes/no)

33/59

1/19

32/40

0.001

 Cardiovascular disease (yes/no)

6/86

1/19

5/67

n.s.

 Pulmonary disease (yes/no)

8/84

3/17

5/67

n.s.

 BMI

21.1

20.8

21.1

n.s.

 WBC (× 10³/mL)

6.50

5.95

6.70

n.s.

 Neutrophils (× 10³/mL)

4.22

3.66

4.68

n.s.

 Hb (g/dL)

13.5

14.0

13.4

n.s.

 Plt (× 10³/mL)

267.0

232.0

274.0

0.075

 TP (g/dL)

7.1

7.2

7.1

n.s.

 Alb (g/dL)

3.9

4.0

3.8

n.s.

 BUN (mg/dL)

13.0

13.0

13.0

n.s.

 Cre (mg/dL)

0.75

0.70

0.77

0.058

 AST (IU/L)

20.0

21.5

19.0

n.s.

 ALT (IU/L)

14.0

18.5

13.0

n.s.

 LDH (IU/L)

181.0

173.5

181.0

n.s.

 ALP (IU/L)

199.0

196.0

199.0

n.s.

 γ s. (IU/L)

38.0

38.5

38.0

n.s.

 Bil (mg/dL)

0.70

0.75

0.60

n.s.

 CRP (mg/dL)

0.10

0.05

0.10

n.s.

 Na (mmol/L)

142

142

142

n.s.

 K (mmol/L)

4.2

4.3

4.2

n.s.

 Cl (mmol/L)

105.0

105.0

105.0

n.s.

 HbA1c (%)

5.6

5.6

5.6

n.s.

 CEA (μg/L)

2.8

2.5

2.8

n.s.

 CA19-9 (U/mL)

11.0

8.0

12.0

n.s.

 SCC (μg/L)

1.3

1.2

1.3

n.s.

 CYFRA (μg/L)

1.9

2.3

1.8

0.084

 p53 U/mL

0.69

0.69

0.69

n.s.

 c T factor (7th)

n.s.

  1a/1b

2/7

0/0

2/7

  2

17

4

13

  3

50

14

36

  4a

5

2

3

  4b

11

0

11

 c N factor (7th)

n.s.

  0

9

2

7

  1

33

6

27

  2

38

9

29

  3

10

3

7

  4

2

0

2

 c stage (7th)

n.s.

  I (IB)

3

0

3

  II (IIA, IIB)

6/10

3/2

3/8

  III (IIIA, IIIB, IIIC)

21/13/16

5/2/2

16/11/14

  IV

23

6

17

 Tumor localization

n.s.

  Ut

10

1

9

  Mt

50

12

38

  Lt

17

5

12

  Ae

2

0

2

  EGJ

13

2

11