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Table 3 Diagnostic potential of multifocal and bilateral tumors presence and tumors size above 5 mm as indicators of lymph node metastasis in PTMC patients

From: Which papillary thyroid microcarcinoma should be treated as “true cancer” and which as “precancer”?

ROC analysis Presence of multifocal tumors Presence of bilateral tumors Presence of tumor ≥ 0.5 cm
AUC (± 95%CI) 0.747 (0.668–0.827) 0.621 (0.529–0.713) 0.827 (0.767–0.888)
P value < 0.0001 < 0.0001 < 0.0001
SE 0.041 0.047 0.031
Sensitivity 0.677 0.242 0.968
Specificity 0.817 1.000 0.687
Accuracy 0.768 0.734 0.785
LR (+) 0.667 1.000 0.625
LR (−) 0.825 0.710 0.975
PPV 0.183 0.000 0.313
NPV 0.323 0.758 0.032
Youden Index 0.495 0.242 0.665
  1. PTMC papillary thyroid microcarcinoma