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Table 5 Correlation of TILs in the tumour central area (TCA) with clinicopathological characteristics in HCC

From: Immunologic cellular characteristics of the tumour microenvironment of hepatocellular carcinoma drive patient outcomes

Variable TIL+/TCA TIL/TCA p value
No. of patients 20 38  
Patient age, years    0.476
 ≤ 60 6 (30.0%) 15 (39.1%)  
 > 60 14 (70.0%) 23 (60.9%)  
Gender    0.732
 Female 15 (75.0%) 30 (78.9%)  
 Male 5 (25.0%) 8 (21.1%)  
Local tumour recurrence    0.933
 Positive 6 (30.0%) 11 (28.9%)  
 Negative 14 (70.0%) 27 (71.1%)  
Overall tumour recurrence    0.546
 Positive 9 (45.0%) 14 (36.8%)  
 Negative 11 (55.0%) 24 (63.2%)  
Metastases    0.884
 Positive 4 (20.0%) 7 (18.4%)  
 Negative 16 (80.0%) 31 (81.6%)  
Multiple tumour nodules    0.100
 Positive 18 (90.0%) 27 (71.1%)  
 Negative 2 (10.0%) 11 (28.9%)  
Tumour size (mm)    0.206
 ≤ 50 2 (10.0%) 9 (23.7%)  
 > 50 18 (90.0%) 29 (76.3%)  
R status    0.148
 Positive 15 (75.0%) 34 (89.5%)  
 Negative 5 (25.0%) 4 (10.5%)  
Angioinvasion    0.717
 Positive 11 (55.0%) 19 (50.0%)  
 Negative 9 (45.0%) 19 (50.0%)  
Lymphangiosis carcinomatosa    0.057
 Positive 9 (45.0%) 30 (78.9%)  
 Negative 11 (45.0%) 8 (21.1%)  
Histologic differentiation    0.576
 Well 3 (15.0%) 8 (21.1%)  
 Moderate/poor 17 (85.0%) 30 (78.9%)  
Pathologic T stage    0.708
 T1/T2 9 (47.4%) 20 (52.6%)  
 T3/T4 10 (52.6%) 18 (47.4%)  
Pathologic N stage    0.296
 Positive 0 (00.0%) 2 (5.3%)  
 Negative 20 (100.0%) 36 (94.7%)  
CD68+ TAMs/TCA    0.008
 Positive 20 (100.0%) 11 (28.9%)  
 Negative 0 (00.0%) 27 (71.1%)