Table 5 Correlation of TILs in the tumour central area (TCA) with clinicopathological characteristics in HCC
Variable | TIL+/TCA | TIL−/TCA | p value |
|---|---|---|---|
No. of patients | 20 | 38 | |
Patient age, years | 0.476 | ||
≤ 60 | 6 (30.0%) | 15 (39.1%) | |
> 60 | 14 (70.0%) | 23 (60.9%) | |
Gender | 0.732 | ||
Female | 15 (75.0%) | 30 (78.9%) | |
Male | 5 (25.0%) | 8 (21.1%) | |
Local tumour recurrence | 0.933 | ||
Positive | 6 (30.0%) | 11 (28.9%) | |
Negative | 14 (70.0%) | 27 (71.1%) | |
Overall tumour recurrence | 0.546 | ||
Positive | 9 (45.0%) | 14 (36.8%) | |
Negative | 11 (55.0%) | 24 (63.2%) | |
Metastases | 0.884 | ||
Positive | 4 (20.0%) | 7 (18.4%) | |
Negative | 16 (80.0%) | 31 (81.6%) | |
Multiple tumour nodules | 0.100 | ||
Positive | 18 (90.0%) | 27 (71.1%) | |
Negative | 2 (10.0%) | 11 (28.9%) | |
Tumour size (mm) | 0.206 | ||
≤ 50 | 2 (10.0%) | 9 (23.7%) | |
> 50 | 18 (90.0%) | 29 (76.3%) | |
R status | 0.148 | ||
Positive | 15 (75.0%) | 34 (89.5%) | |
Negative | 5 (25.0%) | 4 (10.5%) | |
Angioinvasion | 0.717 | ||
Positive | 11 (55.0%) | 19 (50.0%) | |
Negative | 9 (45.0%) | 19 (50.0%) | |
Lymphangiosis carcinomatosa | 0.057 | ||
Positive | 9 (45.0%) | 30 (78.9%) | |
Negative | 11 (45.0%) | 8 (21.1%) | |
Histologic differentiation | 0.576 | ||
Well | 3 (15.0%) | 8 (21.1%) | |
Moderate/poor | 17 (85.0%) | 30 (78.9%) | |
Pathologic T stage | 0.708 | ||
T1/T2 | 9 (47.4%) | 20 (52.6%) | |
T3/T4 | 10 (52.6%) | 18 (47.4%) | |
Pathologic N stage | 0.296 | ||
Positive | 0 (00.0%) | 2 (5.3%) | |
Negative | 20 (100.0%) | 36 (94.7%) | |
CD68+ TAMs/TCA | 0.008 | ||
Positive | 20 (100.0%) | 11 (28.9%) | |
Negative | 0 (00.0%) | 27 (71.1%) |