Table 1 Clinicopathological parameters of patients with DFSP
From: Dermatofibrosarcoma protuberans: surgical management of a challenging mesenchymal tumor
Patient number | Group (A–C) | Gender (M/F) | Diagnosis | Age at diagnosis (years) | Localization | Presentation | Tumor specimen diameter (cm) | Resection margins (cm) | Closure type | Neoadjuvant therapy | Histopathology | Final resection status | Local recurrence free survival after R0 resection (months) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | A | F | DFSP | 42 | Neck | On normal cutis | 1.5 | 1 | Primary | n/a | CD34+, Vimentin+, sm-Actin+ | R0 | 175 |
2 | C | M | DFSP | 46 | Trunk | On normal cutis | 3.1 | 2 | TRAM flap | n/a | CD34+, Actin neg, MIB1 3% | R0 | 145 |
3 | B | M | DFSP | 74 | Gluteal | On normal cutis | 2.3 | 2 | Primary | n/a | CD34+, MIB1 15% | R0 | 135 |
4 | A | F | DFSP | 70 | Trunk | On normal cutis | 6.5 | 1 | Primary | Imatinib mesylate | CD34+, MIB1 2% | R0 | 58 |
5 | A | M | DFSP | 34 | Trunk | On normal cutis | 3.0 | 1 | Primary | n/a | CD34+, vimentin+ | R0 | 113 |
6 | C | F | DFSP | 36 | Trunk | On normal cutis | 1.7 | 0.5 | Pectoralis flap | n/a | CD34+, S100neg., Desmin neg., spindle cells | R0 | 105 |
7 | B | M | DFSP | 33 | Hand | On normal cutis | 0.3 | 0.8 | Gracilis flap | n/a | CD34+, MAC387+ macrophages, factor VIII+ endothelial cells, MIB1 1% | R0 | 103 |
8 | B | M | DFSP | 54 | Trunk | On scar from lipoma excision | 2.0 | 2.5 | LICAP flap | n/a | CD34+ | R0 | 95 |
9 | B | F | DFSP with high-grade sarcomatous transfomation | 46 | Gluteal | On normal cutis | 4.6 | 3 | ALT flap | Radiation therapy (60 Gy) and ifosfamide/doxorubicin | CD34+, ß-catenin+, CD99+, MIB1 50% | R0 | 87 |
10 | B | M | DFSP | 46 | Trunk | On normal cutis | 3.3 | 3 | Primary | n/a | CD34+, PDGFR-alpha+, PDGFR-beta+. MIB1 5–10% | R0 | 88 |
11 | A | F | DFSP | 50 | Trunk | On normal cutis | 2.0 | 1 | Primary | n/a | CD34+, MIB 2% | R0 | 84 |
12 | B | F | DFSP | 89 | Upper extremity | On normal cutis | 1.7 | 1 | Perforator flap | n/a | CD34+ | R0 | 6 |
13 | A | M | DFSP | 46 | Inguinal | On prior scar | 6.5 | 2 | Primary | n/a | CD34+, PDGFR-beta+ | R0 | 63 |
14 | C | F | DFSP | 44 | Trunk | On irritated cutis | 3.5 | 1 | Skin graft | n/a | CD34+, PDGFR-beta+, p16+, MIB 1–5% | R0 | 62 |
15 | A | F | DFSP | 43 | Trunk | On normal cutis | 3.0 | 2 | Perforator flap | n/a | CD34+, MIB 10% | R0 | 55 |
16 | A | F | DFSP | 56 | Lower extremity | On normal cutis | 1.8 | 2 | ALT flap | n/a | CD34+, CD117+ | R0 | 48 |
17 | B | M | DFSP | 81 | Gluteal | On normal cutis | 2.9 | 2 | Primary | n/a | Exophytic tumor, spindle cells; reported as DFSP by pathologist | R0 | 37 |
18 | C | F | DFSP | 61 | Trunk | On scar from nodular fasciitis and fibrous histiocytoma excision | 1.2 | 2 | VRAM flap | n/a | CD34+, MIB1 low | R0 | 12 |
19 | A | F | DFSP | 59 | Inguinal | On scar from abscess excision | 9.0 | 2 | VRAM flap | n/a | CD34+ | R0 | 12 |