The prognostic value of tumor-infiltrating lymphocytes in colorectal cancer differs by anatomical subsite: a systematic review and meta-analysis

Table 1 The pooled results and heterogeneity test (I² test) of the meta-analysis in colon cancer

TIL subset	Tumor location	Outcome indicator	Counting site	No. of extractable data	Pooled HR	95% CI of HR	I² test(%) of subgroup	P value of subgroup	Pooled I² test (%)	P value	References (first author and year)
CD3+	Colon	CSS	IM, ST	2	0.58	0.46–0.74			0%	0.80	Richards 2014
		DFS	IM	2	0.76	0.62–0.93	39%	0.20	72%	0.003	Eriksen 2018, Flahevity 2016
			TC	3	0.59	0.15–2.28	84%	0.002			Guidobomi 2001, Lee 2010, Sinicrope 2009
			ST	1	0.14	0.02–1.07					Lee 2010
		OS	ST+TC	2	0.75	0.64–0.88			40%	0.14	Berntsson 2017
			ST	1							Lee 2010
			IM	1							Eriksen 2018
			TC	2							Guidobomi 2001, Lee 2010
CD8+		CSS	TC	1	0.55	0.39–0.79					Richards 2014
		DFS	IM	2	0.49	0.15–1.64	81%	0.02	72%	0.006	Eriksen 2018, Prall 2004
			TC	2	0.50	0.38–0.65	0%	0.36			Guidobomi 2001, Huang 2018
			TC+IM	1	0.65	0.50–0.85					Flahevity 2016
		OS	ST+TC	2	0.42	0.25–0.70	2%	0.31	64%	0.02	Berntsson 2017
			IM	2	0.31	0.04–2.69	79%	0.03			Eriksen 2018, Prall 2004
			TC	2	0.49	0.27–0.91	46%	0.18			Guidobomi 2001, Yoon 2012
FOXP3+		CSS	IM, TC	4	0.68	0.58–0.80			0%	0.79	Marlk 2017, Salama 2012, Ling 2014
		DFS	ST,TC	3	0.28	0.14–0.54			0%	0.57	Lee 2010, Correale 2010
		OS	ST	3	0.38	0.22–0.67	0%	0.54	44%	0.07	Lee 2010, Correale 2010, Yoon 2012
			TC	4	0.72	0.56–0.95	0%	0.41			Lee 2010, Xu 2013, Yoon 2012, Zeestraten 2014
			ST+TC	2	0.77	0.51–1.17	39%	0.20			Berntsson 2017
			Blood	1	3.78	0.92–15.52					Sellitto 2011
CD45RO+		DFS	ST, TC	2	0.22	0.10–0.53			0%	0.80	Lee 2010
CD45RO+		OS	TC, ST, NA	3	0.18	0.06–0.54			0%	0.46	Lee 2010, Lee 2013

OS overall survival, DFS disease-free survival, CSS cancer-specific survival; TC tumor center, IM invasive margin, ST tumor stroma; TILs tumor infiltrating lymphocytes, FOXP3 Fork head box P3, TC+ST the immune score including tumor-infiltrating lymphocytes score of tumor center and tumor stroma, TC+IM the immune score including tumor center and invasive and invasive margin, No number

ISSN: 1477-7819