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Table 2 Recurrence rates with likelihood ratios and cumulative recurrence-free survival (RFS) rates at 2 years follow-up (2YFU), 5 years follow-up (5YFU), and 10 years follow-up (10YFU). Results are depicted for the whole collective and for cases with surgery at own institution (in domo) and surgery elsewhere (ex domo). Statistically significant hydrogen peroxide effects were found for all cases treated in domo and for the whole collective

From: Retrospective analysis of 51 intralesionally treated cases with progressed giant cell tumor of the bone: local adjuvant use of hydrogen peroxide reduces the risk for tumor recurrence

 

n

Recurrences (recurrence rate)

Likelihood ratio of recurrence (chi-square test)

2YFU-RFS (standard error)

5YFU-RFS (standard error)

10YFU-RFS (standard error)

Log-rank test for differences in RFS

Whole collective

51

21 (0.41)

 

0.69 (0.07)

0.54 (0.08)

0.54 (0.08)

 

Surgery in domo

39

11 (0.28)

11.9 (p = 0.001)

0.72 (0.08)

0.68 (0.08)

0.68 (0.08)

p = 0.001

Surgery ex domo

12

10 (0.83)

 

0.42 (0.14)

0.17 (0.11)

0.17 (0.11)

 

With H2O2 (in domo)

24

4 (0.17)

4.1 (p = 0.04)

0.86 (0.07)

0.79 (0.10)

0.79 (0.10)

p = 0.02

Without H2O2 (in domo)

15

7 (0.47)

 

0.48 (0.14)

0.48 (0.14)

0.48 (0.14)

 

With H2O2 (whole collective)

27

6 (0.22)

8.8 (p = 0.004)

0.80 (0.08)

0.74 (0.09)

0.74 (0.09)

p = 0.002

Without H2O2 (whole collective)

24

15 (0.63)

 

0.47 (0.11)

0.31 (0.10)

0.31 (0.10)