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Table 2 Cox proportional hazards regression analysis including (a) tumour side left/right and (b) tumour subsite

From: Lymph node yield and tumour subsite are associated with survival in stage I–III colon cancer: results from a national cohort study

Variable Hazard ratio (95% CI) p value
a. Tumour side left/right
 Male 1  
 Female 0.819 (0.771–0.869) < 0.0001
 ASA I compared to ASA II 0.728 (0.658–0.806) < 0.0001*
 ASA II compared to ASA III 0.613 (0.573–0.655) < 0.0001*
 ASA III compared to ASA IV 0.646 (0.552–0.756) < 0.0001*
 Laparoscopic surgery 1  
 Open surgery 1.127 (1.033–1.230) 0.007
 No blood transfusion 1  
 Blood transfusion 1.315 (1.232–1.403) < 0.0001
 Age 65 years compared to 65–75 years 0.693 (0.615–0.781) < 0.0001*
 Age 65 years compared to age > 75 years 0.504 (0.472–0.537) < 0.0001*
 Year of diagnosis 0.967 (0.952–0.983) < 0.0001*
 LNY 0–5 compared to LNY 5–11 1.135 (1.019–1.264) 0.021*
 LNY 5–11 compared to LNY 12–17 1.240 (1.148–1.340) < 0.0001*
 LNY 12–17 compared to LNY ≥ 18 1.139 (1.054–1.230) < 0.001*
 N0 1  
 N1 + 2 0.609 (0.558–0.665) < 0.0001
 pT1 compared to pT2 0.817 (0.673–0.992) 0.041*
 pT2 compared to pT3 0.824 (0.739–0.917) < 0.0001*
 pT3 compared to pT4 0.614 (0.571–0.661) < 0.0001*
 Tumour side left 1  
 Tumour side right 1.069 (1.005–1.136) 0.033
 Charlson score 0 compared to score 1 0.792 (0.725–0.864) < 0.0001
 Charlson score 1 compared to score 2 0.908 (0.793–1.040) 0.165
 Charlson score 2 compared to score 3 0.835 (0.735–0.948) 0.005
 No leak 1  
 Leak 1.759 (1.575–1.965) < 0.0001
 Elective surgery 1  
 Acute surgery 1.756 (1.628–1.893) < 0.0001
b. Tumour subsite
 Male 1  
 Female 0.820 (0.772–0.870) < 0.0001
 ASA I compared to ASA II 0.729 (0.659–0.806) < 0.0001*
 ASA II compared to ASA III 0.613 (0.573–0.656) < 0.0001*
 ASA III compared to ASA IV 0.646 (0.552–0.756) < 0.0001*
 Laparoscopic surgery 1  
 Open surgery 1.120 (1.026–1.233) 0.007
 No blood transfusion 1  
 Blood transfusion 1.309 (1.226–1.397) < 0.0001
 Age 65 years compared to age 65–75 years 0.691 (0.614–0.779) < 0.0001*
 Age 65 years compared to age > 75 years 0.503 (0.471–0.536) < 0.0001*
 Year of diagnosis 0.967 (0.951–0.982) < 0.0001*
 LNY 0–5 compared to LNY 5–11 1.134 (1.018–1.262) 0.023*
 LNY 5–11 compared to LNY 12–17 1.240 (1.147–1.339) < 0.0001*
 LNY 12–17 compared to LNY ≥ 18 1.142 (1.057–1.234) < 0.001*
 N0 1  
 N1 + 2 0.606 (0.555–0.663) < 0.0001
 pT1 compared to pT2 0.818 (0.674–0.993) 0.042*
 pT2 compared to pT3 0.825 (0.740–0.919) < 0.0001*
 pT3 compared to pT4 0.614 (0.571–0.660) < 0.0001*
 Sigmoid colon 1  
 Coecum 1.077 (0.993–1.168) 0.074
 Ascending colon 1.032 (0.937–1.137) 0.519
 Hepatic flexure 1.213 (1.084–1.358) < 0.001
 Transverse colon 1.058 (0.948–1.180) 0.315
 Splenic flexure 1.181 (1.026–1.359) 0.021
 Descending colon 0.945 (0.813–1.109) 0.514
 Charlson score 0 compared to score 1 0.792 (0.725–0.864) < 0.0001*
 Charlson score 1 compared to score 2 0.908 (0.793–1.040) 0.165*
 Charlson score 2 compared to score 3 0.835 (0.735–0.948) 0.005*
 No leak 1  
 Leak 1.753 (1.569–1.960) < 0.0001
 Elective surgery 1  
 Acute surgery 1.753 (1.626–1.891) < 0.0001
  1. ASA American Society of Anaesthesiologists, LNY lymph node yield
  2. *Each level compared to the preceding level