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Table 2 Cox proportional hazards regression analysis including (a) tumour side left/right and (b) tumour subsite

From: Lymph node yield and tumour subsite are associated with survival in stage I–III colon cancer: results from a national cohort study

Variable

Hazard ratio (95% CI)

p value

a. Tumour side left/right

 Male

1

 

 Female

0.819 (0.771–0.869)

< 0.0001

 ASA I compared to ASA II

0.728 (0.658–0.806)

< 0.0001*

 ASA II compared to ASA III

0.613 (0.573–0.655)

< 0.0001*

 ASA III compared to ASA IV

0.646 (0.552–0.756)

< 0.0001*

 Laparoscopic surgery

1

 

 Open surgery

1.127 (1.033–1.230)

0.007

 No blood transfusion

1

 

 Blood transfusion

1.315 (1.232–1.403)

< 0.0001

 Age 65 years compared to 65–75 years

0.693 (0.615–0.781)

< 0.0001*

 Age 65 years compared to age > 75 years

0.504 (0.472–0.537)

< 0.0001*

 Year of diagnosis

0.967 (0.952–0.983)

< 0.0001*

 LNY 0–5 compared to LNY 5–11

1.135 (1.019–1.264)

0.021*

 LNY 5–11 compared to LNY 12–17

1.240 (1.148–1.340)

< 0.0001*

 LNY 12–17 compared to LNY ≥ 18

1.139 (1.054–1.230)

< 0.001*

 N0

1

 

 N1 + 2

0.609 (0.558–0.665)

< 0.0001

 pT1 compared to pT2

0.817 (0.673–0.992)

0.041*

 pT2 compared to pT3

0.824 (0.739–0.917)

< 0.0001*

 pT3 compared to pT4

0.614 (0.571–0.661)

< 0.0001*

 Tumour side left

1

 

 Tumour side right

1.069 (1.005–1.136)

0.033

 Charlson score 0 compared to score 1

0.792 (0.725–0.864)

< 0.0001

 Charlson score 1 compared to score 2

0.908 (0.793–1.040)

0.165

 Charlson score 2 compared to score 3

0.835 (0.735–0.948)

0.005

 No leak

1

 

 Leak

1.759 (1.575–1.965)

< 0.0001

 Elective surgery

1

 

 Acute surgery

1.756 (1.628–1.893)

< 0.0001

b. Tumour subsite

 Male

1

 

 Female

0.820 (0.772–0.870)

< 0.0001

 ASA I compared to ASA II

0.729 (0.659–0.806)

< 0.0001*

 ASA II compared to ASA III

0.613 (0.573–0.656)

< 0.0001*

 ASA III compared to ASA IV

0.646 (0.552–0.756)

< 0.0001*

 Laparoscopic surgery

1

 

 Open surgery

1.120 (1.026–1.233)

0.007

 No blood transfusion

1

 

 Blood transfusion

1.309 (1.226–1.397)

< 0.0001

 Age 65 years compared to age 65–75 years

0.691 (0.614–0.779)

< 0.0001*

 Age 65 years compared to age > 75 years

0.503 (0.471–0.536)

< 0.0001*

 Year of diagnosis

0.967 (0.951–0.982)

< 0.0001*

 LNY 0–5 compared to LNY 5–11

1.134 (1.018–1.262)

0.023*

 LNY 5–11 compared to LNY 12–17

1.240 (1.147–1.339)

< 0.0001*

 LNY 12–17 compared to LNY ≥ 18

1.142 (1.057–1.234)

< 0.001*

 N0

1

 

 N1 + 2

0.606 (0.555–0.663)

< 0.0001

 pT1 compared to pT2

0.818 (0.674–0.993)

0.042*

 pT2 compared to pT3

0.825 (0.740–0.919)

< 0.0001*

 pT3 compared to pT4

0.614 (0.571–0.660)

< 0.0001*

 Sigmoid colon

1

 

 Coecum

1.077 (0.993–1.168)

0.074

 Ascending colon

1.032 (0.937–1.137)

0.519

 Hepatic flexure

1.213 (1.084–1.358)

< 0.001

 Transverse colon

1.058 (0.948–1.180)

0.315

 Splenic flexure

1.181 (1.026–1.359)

0.021

 Descending colon

0.945 (0.813–1.109)

0.514

 Charlson score 0 compared to score 1

0.792 (0.725–0.864)

< 0.0001*

 Charlson score 1 compared to score 2

0.908 (0.793–1.040)

0.165*

 Charlson score 2 compared to score 3

0.835 (0.735–0.948)

0.005*

 No leak

1

 

 Leak

1.753 (1.569–1.960)

< 0.0001

 Elective surgery

1

 

 Acute surgery

1.753 (1.626–1.891)

< 0.0001

  1. ASA American Society of Anaesthesiologists, LNY lymph node yield
  2. *Each level compared to the preceding level