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Table 5

From: Laparoscopic versus open gastrectomy for locally advanced gastric cancer: a systematic review and meta-analysis of randomized controlled studies

Author Published year References Inclusion criteria Exclusion criteria
Cai 2011 Cai, Wei et al. [19] Gastric cancer
Potentially resectable local tumors without distant metastatic
Tumors which need to be controlled by operation against bleeding and obstruction
Patients needed thoraco-abdominal surgery
Patients with other malignant tumors
History of major upper abdominal surgery
Gastric stump cancer
Recurrent cancer
Cardiovascular risk greater than New York Heart Association grade II
Severe liver disease (Child B or C)
Renal dysfunction.
Hu 2016 Hu, Huang et al. [22]
Hu, Huang et al. [26]
Patients aged 18 to 75 years
Gastric adenocarcinoma proven by endoscopic biopsy
cT2-4aN0-3M0 at preoperative evaluation according to AJCC
Cancer Staging Manual, 7th Edition
Expected curative resection via distal subtotal gastrectomy with D2 lymphadenectomy
ECOG status 0 or 1
Written informed consent
Pregnant or breastfeeding women
Severe mental disorder
Previous upper abdominal surgery (except laparoscopic cholecystectomy)
Previous gastrectomy, endoscopic mucosal resection, or endoscopic submucosal dissection
Enlarged or bulky regional lymph node diameter larger than 3 cm based on preoperative imaging
Other malignant disease within the past 5 years
Previous neoadjuvant chemotherapy or radiotherapy
Unstable angina, myocardial infarction, or cerebrovascular accident within the past 6 months
Continuous systematic administration of corticosteroids within 1 month before the study
Requirement of simultaneous surgery for other diseases
Emergency surgery due to a complication (bleeding, obstruction, or perforation) caused by gastric cancer
FEV1, 50% of predicted values
Park 2017 Park, Yoon et al. [31]
Kim, Park et al. [27]
Kim, Park et al. [20]
Nam, Kim et al. [21]
Patients aged 20 to 80 years
Histologically proven adenocarcinoma of the stomach
Clinical stage cT2-T4a cN0-3
Participation in another trial interfering with the outcome of the present study
Language problems
Lack of compliance
Mental inability
Synchronous or previous malignant disease (except curatively treated in situ cervical cancer or curatively resected nonmelanoma skin cancer)
Systemic administration of corticosteroids,
Unstable angina or myocardial infarction within 6 months
Severe respiratory disease
ASA score > 3
Previous major abdominal surgery
Previous chemo- or radiotherapy
Inadequate liver, kidney, and bone-marrow functions
ECOG status > 1
Shi 2018 Shi, Xu et al. [24] Patients aged 18–80 years
Gastric adenocarcinoma proven by endoscopic biopsy
Preoperative cancer stage cT2-3N0-3M0 (according to AJCC-6th TNM staging)
ASA score > 3
Severe mental disorder
Surgical history of upper abdomen (except laparoscopic cholecystectomy)
Presence of other malignancies
History of chemotherapy or radiation therapy
Unstable angina or myocardial infarction within the past 6 months
FEV1 less than 50% of predicted value
Abdominal wall hernia
Diaphragmatic hernia
Coagulation disorder
Portal hypertension
Wang 2018 Wang, Xing et al. [25] Patients age ≥ 18 years pathologically confirmed primary gastric adenocarcinoma proven by endoscopic biopsy
Tumor located in the lower part of the stomach, potentially resectable by subtotal gastrectomy and D2 lymph node dissection
Preoperative cancer stage cT2-4aN0-3M0 (according to AJCC-7th TNM staging)
ECOG status of 0 or 1, or the American Society of Anesthesiology
Classes of I, II, or III
Signed informed consent
Surgical history of upper abdomen (except laparoscopic cholecystectomy)
Previous gastrectomy, including endoscopic submucosal dissection and endoscopic mucosal resection
Integrated or enlarged lymph node with maximum diameter larger than 3 cm according to preoperative imaging
Other malignant diseases (within 5 years)
Preoperative chemotherapy, immunotherapy, or radiotherapy
Other illnesses needed operation concurrently
Complications (bleeding, perforation, or obstruction) required emergency surgery due to primary gastric malignancy
FEV1 less than 50% of predicted value
Patient suffered from bleeding tendency disease such as hemophilia or took anti-coagulant medication due to deep vein thrombosis