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Table 5

From: Laparoscopic versus open gastrectomy for locally advanced gastric cancer: a systematic review and meta-analysis of randomized controlled studies

Author

Published year

References

Inclusion criteria

Exclusion criteria

Cai

2011

Cai, Wei et al. [19]

Gastric cancer

Potentially resectable local tumors without distant metastatic

Tumors which need to be controlled by operation against bleeding and obstruction

Patients needed thoraco-abdominal surgery

Patients with other malignant tumors

History of major upper abdominal surgery

Gastric stump cancer

Recurrent cancer

ASA > III

Cardiovascular risk greater than New York Heart Association grade II

Severe liver disease (Child B or C)

Renal dysfunction.

Hu

2016

Hu, Huang et al. [22]

Hu, Huang et al. [26]

Patients aged 18 to 75 years

Gastric adenocarcinoma proven by endoscopic biopsy

cT2-4aN0-3M0 at preoperative evaluation according to AJCC

Cancer Staging Manual, 7th Edition

Expected curative resection via distal subtotal gastrectomy with D2 lymphadenectomy

ECOG status 0 or 1

ASA I, II, or III

Written informed consent

Pregnant or breastfeeding women

Severe mental disorder

Previous upper abdominal surgery (except laparoscopic cholecystectomy)

Previous gastrectomy, endoscopic mucosal resection, or endoscopic submucosal dissection

Enlarged or bulky regional lymph node diameter larger than 3 cm based on preoperative imaging

Other malignant disease within the past 5 years

Previous neoadjuvant chemotherapy or radiotherapy

Unstable angina, myocardial infarction, or cerebrovascular accident within the past 6 months

Continuous systematic administration of corticosteroids within 1 month before the study

Requirement of simultaneous surgery for other diseases

Emergency surgery due to a complication (bleeding, obstruction, or perforation) caused by gastric cancer

FEV1, 50% of predicted values

Park

2017

Park, Yoon et al. [31]

Kim, Park et al. [27]

Kim, Park et al. [20]

Nam, Kim et al. [21]

Patients aged 20 to 80 years

Histologically proven adenocarcinoma of the stomach

Clinical stage cT2-T4a cN0-3

Participation in another trial interfering with the outcome of the present study

Language problems

Lack of compliance

Mental inability

Synchronous or previous malignant disease (except curatively treated in situ cervical cancer or curatively resected nonmelanoma skin cancer)

Systemic administration of corticosteroids,

Unstable angina or myocardial infarction within 6 months

Severe respiratory disease

ASA score > 3

Previous major abdominal surgery

Previous chemo- or radiotherapy

Inadequate liver, kidney, and bone-marrow functions

ECOG status > 1

Shi

2018

Shi, Xu et al. [24]

Patients aged 18–80 years

Gastric adenocarcinoma proven by endoscopic biopsy

Preoperative cancer stage cT2-3N0-3M0 (according to AJCC-6th TNM staging)

Pregnancy

ASA score > 3

Severe mental disorder

Surgical history of upper abdomen (except laparoscopic cholecystectomy)

Presence of other malignancies

History of chemotherapy or radiation therapy

Unstable angina or myocardial infarction within the past 6 months

FEV1 less than 50% of predicted value

Abdominal wall hernia

Diaphragmatic hernia

Coagulation disorder

Portal hypertension

Wang

2018

Wang, Xing et al. [25]

Patients age ≥ 18 years pathologically confirmed primary gastric adenocarcinoma proven by endoscopic biopsy

Tumor located in the lower part of the stomach, potentially resectable by subtotal gastrectomy and D2 lymph node dissection

Preoperative cancer stage cT2-4aN0-3M0 (according to AJCC-7th TNM staging)

ECOG status of 0 or 1, or the American Society of Anesthesiology

Classes of I, II, or III

Signed informed consent

Surgical history of upper abdomen (except laparoscopic cholecystectomy)

Previous gastrectomy, including endoscopic submucosal dissection and endoscopic mucosal resection

Integrated or enlarged lymph node with maximum diameter larger than 3 cm according to preoperative imaging

Other malignant diseases (within 5 years)

Preoperative chemotherapy, immunotherapy, or radiotherapy

Other illnesses needed operation concurrently

Complications (bleeding, perforation, or obstruction) required emergency surgery due to primary gastric malignancy

FEV1 less than 50% of predicted value

Patient suffered from bleeding tendency disease such as hemophilia or took anti-coagulant medication due to deep vein thrombosis