Table 1 An overview of the trials included in the meta-analysis
Author | References | Country | N (postrandomization drop outs N (%)) | Type of intervention | Outcome | ||
|---|---|---|---|---|---|---|---|
Comparator /control | LAD | Extend of resection | |||||
Cai | Cai et al. [19] | China Single-center | 123 (27 (22%)) | LAG/OG | D2 | PG DG TG | Operative outcomes: operating time, intraoperative blood transfusion, estimated blood loss, tumor size, number of lymph nodes harvested, frequency of open conversion Postoperative recovery: days with a body temperature > 37 °C, time to first flatus, number of days to get out of bed, time to first liquid intake, hospital stay Postoperative morbidity: morbidity rate, type, and frequency of postoperative complications Postoperative mortality  Long-term results: survival at mean follow-up |
Hu | Hu et al. [22] Hu et al. [26] | China Multi-center | 1056 (17 (2%)) | LAG/OG | D2 | DG | Operative outcomes: operating time, estimated blood loss, frequency of open conversion, intraoperative blood transfusion, proximal resection margins, distal resection margins, number of lymph nodes harvested, length of incision, intraoperative complications Postoperative recovery: time to ambulation, time to first flatus, time to first liquid intake, postoperative hospital stay Postoperative morbidity: severity and frequency of postoperative complications (Clavien–Dindo), type of postoperative complications Postoperative mortality  Long-term results: 3-year DFS (primary outcome, results pending) |
Park | Park et al. [20] Kim et al. [23] Kim et al. [21] Nam et al. [23] | Korea Multi-center | 204 (8 (4%)) | LAG/OG | D2 | DG | Operative outcomes: Noncompliance rate to nodal dissection (primary outcome), number of lymph nodes harvested, operation time, resectability, intraoperative complications, Postoperative recovery: time to first liquid intake, length of hospital stay, inflammatory response markers, delivery of adjuvant chemotherapy Postoperative morbidity: severity and frequency of postoperative complications (ASCPC) Postoperative mortality  Long-term results: 3-year DFS |
Shi | Shi et al. [24] | China Single-center | 328 (6 pre-randomization) | LAG/OG | D2 | PG DG TG | Operative outcomes: operation time, estimated blood loss, intraoperative blood transfusion, number of lymph nodes harvested, frequency of open conversion Postoperative recovery: analgesic injection use, time to first flatus, time to first liquid intake, time to ambulation, postoperative hospital stay, Postoperative morbidity: severity and frequency of postoperative complications (Clavien–Dindo), type of postoperative complications, frequency of reoperation Postoperative mortality  Long-term results: 5-year OS (primary outcome, results pending) |
Wang | Wang et al. [25] | China Multi-center | 446 (4 (1%)) | LAG/OG | D2 | DG | Operative outcomes: operating time, estimated blood loss, frequency of open conversion, intraoperative blood transfusion, proximal resection margins, distal resection margins, number of lymph nodes harvested, length of incision, intraoperative complications Postoperative recovery: time to ambulation, time to first flatus, time to first liquid intake, postoperative hospital stay Postoperative morbidity: overall postoperative morbidity (primary outcome), severity and frequency of postoperative complications (Clavien–Dindo), type of postoperative complications Postoperative mortality  Long-term results: 3-year DFS (results pending) |