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Table 1 An overview of the trials included in the meta-analysis

From: Laparoscopic versus open gastrectomy for locally advanced gastric cancer: a systematic review and meta-analysis of randomized controlled studies

Author References Country N (postrandomization drop outs N (%)) Type of intervention Outcome
Comparator /control LAD Extend of resection
Cai Cai et al. [19] China
Single-center
123 (27 (22%)) LAG/OG D2 PG
DG
TG
Operative outcomes: operating time, intraoperative blood transfusion, estimated blood loss, tumor size, number of lymph nodes harvested, frequency of open conversion
Postoperative recovery: days with a body temperature > 37 °C, time to first flatus, number of days to get out of bed, time to first liquid intake, hospital stay
Postoperative morbidity: morbidity rate, type, and frequency of postoperative complications
Postoperative mortality
 Long-term results: survival at mean follow-up
Hu Hu et al. [22]
Hu et al. [26]
China
Multi-center
1056 (17 (2%)) LAG/OG D2 DG Operative outcomes: operating time, estimated blood loss, frequency of open conversion, intraoperative blood transfusion, proximal resection margins, distal resection margins, number of lymph nodes harvested, length of incision, intraoperative complications
Postoperative recovery: time to ambulation, time to first flatus, time to first liquid intake, postoperative hospital stay
Postoperative morbidity: severity and frequency of postoperative complications (Clavien–Dindo), type of postoperative complications
Postoperative mortality
 Long-term results: 3-year DFS (primary outcome, results pending)
Park Park et al. [20]
Kim et al. [23]
Kim et al. [21]
Nam et al. [23]
Korea
Multi-center
204 (8 (4%)) LAG/OG D2 DG Operative outcomes: Noncompliance rate to nodal dissection (primary outcome), number of lymph nodes harvested, operation time, resectability, intraoperative complications,
Postoperative recovery: time to first liquid intake, length of hospital stay, inflammatory response markers, delivery of adjuvant chemotherapy
Postoperative morbidity: severity and frequency of postoperative complications (ASCPC)
Postoperative mortality
 Long-term results: 3-year DFS
Shi Shi et al. [24] China
Single-center
328 (6 pre-randomization) LAG/OG D2 PG
DG
TG
Operative outcomes: operation time, estimated blood loss, intraoperative blood transfusion, number of lymph nodes harvested, frequency of open conversion
Postoperative recovery: analgesic injection use, time to first flatus, time to first liquid intake, time to ambulation, postoperative hospital stay,
Postoperative morbidity: severity and frequency of postoperative complications (Clavien–Dindo), type of postoperative complications, frequency of reoperation
Postoperative mortality
 Long-term results: 5-year OS (primary outcome, results pending)
Wang Wang et al. [25] China
Multi-center
446 (4 (1%)) LAG/OG D2 DG Operative outcomes: operating time, estimated blood loss, frequency of open conversion, intraoperative blood transfusion, proximal resection margins, distal resection margins, number of lymph nodes harvested, length of incision, intraoperative complications
Postoperative recovery: time to ambulation, time to first flatus, time to first liquid intake, postoperative hospital stay
Postoperative morbidity: overall postoperative morbidity (primary outcome), severity and frequency of postoperative complications (Clavien–Dindo), type of postoperative complications
Postoperative mortality
 Long-term results: 3-year DFS (results pending)
  1. PG proximal gastrectomy, DG distal gastrectomy, TG total gastrectomy, LAG laparoscopic-assisted gastrectomy, OG open gastrectomy, LAD lymphadenectomy