Staging of gastric cancer with the Clinical Stage Prediction score

Table 2 Analysis of preoperative factors and tumor stage

	Stage I/II	Percent	Stage III/IV	Percent	Total	Univariate analysis	Multivariate analysis
	n = 1769		n = 953			P value	P value
Age	62.0 ± 11.4		63.7 ± 11.8			0.0013	0.3454
Sex	F354/M704		F312/M630		F666/M1334	0.6327
Tumor markers
CA19-9	139	33.74	273	66.26	412	0.0002	0.3063
CEA	167	41.34	237	58.66	404	< 0.0001	0.0031
Tumor diameter
≤ 59	1441	86.4	225	13.6	1666
≥ 60	328	31.06	728	68.94	1056	< 0.0001	< 0.0001
Location/extent
Anterior wall	283	77.11	84	2.89	3667	< 0.0001	0.5661
Posterior wall	427	77.5	124	2.5	551	< 0.0001	0.1243
Lesser curvature	705	66.89	349	33.11	1054	0.0987
Greater curvature	304	68.93	137	31.07	441	0.0578
Circumferential	50	16.18	259	83.82	309	< 0.0001	0.0205
Upper third	307	56	241	433.98	548	< 0.0001	0.7119
Middle third	855	69.85	369	30.15	1224	< 0.0001	0.3593
Lower third	607	63.89	343	36.11	950	0.3809
Esophagus	39	23.64	126	76.36	165	< 0.0001	0.0611
duodenum	43	25	129	75	172	< 0.0001	0.2652
Histology
TB1	449	82.39	96	17.61	545	< 0.0001	0.8469
TB2	436	63.01	256	36.99	692	0.2053
por1	75	53.96	64	46.04	139	0.0061	0.7613
por2	471	52.63	424	47.37	895	< 0.0001	0.221
SIG	241	93.05	18	6.95	259	< 0.0001	0.133
PAP	56	64.37	31	35.63	87	0.9017
MUC	29	34.12	56	67.88	85	< 0.0001	0.0225
ASQ	2	33.33	4	66.67	6	0.1924
Macroscopic type
Type 0	1278	98.38	21	1.62	1299	< 0.0001	0.0003
Type 1	53	62.35	32	37.65	85	0.6443
Type 2	146	44.11	185	55.89	331	< 0.0001	< 0.0001
Type 3	241	32.01	512	67.99	753	< 0.0001	< 0.0001
Type 4	41	17.83	189	82.17	230	< 0.0001	0.0032

When 21 factors that were significant by univariate analysis were used as covariates for multivariate logistic regression analysis, the significant factors for discriminating tumor stage (I/II vs. III/IV) were tumor markers (CEA and CA19-9), tumor diameter ≥ 60 mm, macroscopic type (type 0, type 2, type 3, and type 4), mucinous histology, and infiltration of the esophagus. Abbreviations: TB1 well-differentiated adenocarcinoma, TB2 moderately differentiated adenocarcinoma, por1 solid poorly differentiated adenocarcinoma, por2 non-solid poorly differentiated adenocarcinoma, SIG signet ring cell carcinoma, PAP papillary adenocarcinoma, MUC mucinous adenocarcinoma, ASQ adenosquamous carcinoma

ISSN: 1477-7819