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Table 5 Univariate analysis of FN and αvβ3 expression and osteosarcoma patient survival based on the log-rank test

From: Clinicopathological and prognostic values of fibronectin and integrin αvβ3 expression in primary osteosarcoma

Characteristics Case number Disease-free survival (months) Overall survival (months)
Mean SD 95%CI P value Mean SD 95%CI P value
FN
 High 19 21.74 4.83 12.28–31.19 < 0.001   42.65 6.43 30.04–55.26 < 0.001  
 Low/negative 41 61.08 5.19 50.91–71.25    75.16 3.75 67.81–82.52   
αvβ3
 High 16 16.06 3.34 9.51–22.62 < 0.001   33.38 6.08 21.45–45.30 < 0.001  
 Low/negative 44 61.41 4.96 51.69–71.13    77.30 3.31 70.80–83.79   
FN+/αvβ3+ 10 15.10 2.90 9.42–20.78 < 0.001   24.10 3.22 17.80–30.41 < 0.001  
 vs. othersa 50 55.60 4.91 45.98–65.22    73.31 3.61 66.23–80.39   
FN+/αvβ3+ 10 15.10 2.90 9.42–20.78 < 0.001b 0.177c 24.10 3.22 17.80–30.41 < 0.001b 0.005c
FN+/αvβ3 plus FN/αvβ3+ 15 27.60 6.75 14.36–40.84 < 0.001b   58.57 7.41 44.06–73.09 0.022b  
FN/αvβ3 35 67.14 5.09 57.16–77.13    78.43 3.57 71.43–85.43   
  1. SD standard deviation, CI confidence interval
  2. +High expression; low/negative expression; aFN+/αvβ3 plus FN/αvβ3+ plus FN/αvβ3; bvs. FN/αvβ3; cvs. FN+/αvβ3 plus FN/αvβ3+