Clinicopathological and prognostic values of fibronectin and integrin αvβ3 expression in primary osteosarcoma

Table 4 Association between co-expression of FN and αvβ3 and clinicopathological characteristics in osteosarcoma

Clinicopathologic data	Case number	FN⁺/αvβ3⁺ (n = 10)	Others^a (n = 39)	FN⁻/αvβ3⁻ (n = 11)	P value
Sex
Male	38	7	20	11	0.011
Female	22	3	19	0
Age (years)
< 18	26	5	15	6	NS
≥ 18	34	5	24	5
Tumor size (cm)
< 5	23	3	16	4	NS
≥ 5	37	7	23	7
Tumor location
Tibia or femur	40	7	25	8	NS
Other location	20	3	14	3
Histologic subtype
Conventional	55	9	36	10	NS
Special	5	1	3	1
Enneking staging
I-IIA	21	2	11	8	0.013
IIB	39	8	28	3
Response to chemotherapy*
Good	28	0	20	8	0.002
Poor	32	10	19	3

NS no significance
*Good: tumor necrosis ≥ 90%; poor: tumor necrosis < 90%; ⁺high expression; ⁻low/negative expression; ^aFN⁺/αvβ3⁻ plus FN⁻/αvβ3⁺

ISSN: 1477-7819