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Table 4 Association between co-expression of FN and αvβ3 and clinicopathological characteristics in osteosarcoma

From: Clinicopathological and prognostic values of fibronectin and integrin αvβ3 expression in primary osteosarcoma

Clinicopathologic data Case number FN+/αvβ3+ (n = 10) Othersa (n = 39) FN/αvβ3 (n = 11) P value
Sex
 Male 38 7 20 11 0.011
 Female 22 3 19 0  
Age (years)
 < 18 26 5 15 6 NS
 ≥ 18 34 5 24 5  
Tumor size (cm)
 < 5 23 3 16 4 NS
 ≥ 5 37 7 23 7  
Tumor location
 Tibia or femur 40 7 25 8 NS
 Other location 20 3 14 3  
Histologic subtype
 Conventional 55 9 36 10 NS
 Special 5 1 3 1  
Enneking staging
 I-IIA 21 2 11 8 0.013
 IIB 39 8 28 3  
Response to chemotherapy*
 Good 28 0 20 8 0.002
 Poor 32 10 19 3  
  1. NS no significance
  2. *Good: tumor necrosis ≥ 90%; poor: tumor necrosis < 90%; +high expression; low/negative expression; aFN+/αvβ3 plus FN/αvβ3+