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Table 3 Association between individual FN and αvβ3 expression and clinicopathological characteristics in osteosarcoma

From: Clinicopathological and prognostic values of fibronectin and integrin αvβ3 expression in primary osteosarcoma

Clinicopathologic data Case number FN αvβ3
High (n = 19) Low/Neg (n = 41) P value High (n = 16) Low/Neg (n = 44) P value
Sex
 Male 38 11 27 NS 9 29 NS
 Female 22 8 14   7 15  
Age (years)
 < 18 26 6 20 NS 8 18 NS
 ≥ 18 34 13 21   8 26  
Tumor size (cm)
 < 5 23 6 17 NS 4 19 NS
 ≥ 5 37 13 24   12 25  
Tumor location
 Tibia or femur 40 11 25 NS 11 29 NS
 Other location 20 4 16   5 15  
Histologic subtype
 Conventional 55 17 38 NS 14 41 NS
 Special 5 2 3   2 3  
Enneking staging
 I-IIA 21 4 17 NS 2 19 0.028
 IIB 39 15 24   14 25  
Response to chemotherapya
 Good 28 3 25 0.001 2 26 0.002
 Poor 32 16 16   14 19  
  1. Neg negative, NS no significance
  2. aGood: tumor necrosis ≥ 90%, poor: tumor necrosis < 90%