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Table 1 Characteristics of the trials

From: Perioperative transfusion and the prognosis of colorectal cancer surgery: a systematic review and meta-analysis

ID

Country

Tumour type

Sample size

Transfusion trigger

Type of blood products

Outcomes

NOS (stars)

BT+

BT−

Total

1 Tarantino I 2013 [1]

Switzerland

Colonic

148

161

309

OS

7

2 Gunka I 2013 [2]

Czech

Colorectal

132

451

583

OS

7

3 Amri R 2017 [3]

USA

Colonic

305

1118

1423

OS, CSS

8

4 Morner MEM 2016 [4]

Sweden

Colorectal

199

297

496

OS

8

5 Qiu L 2015 [8]

China

Colorectal

803

601

1404

Hb < 6 g/dL, Hb 6–10 g/dL according to cardiopulmonary function

OS, postoperative complications

7

6 Miki C 2006 [9]

Japan

Colorectal

35

82

117

OS, postoperative complications

8

7 Meng J 2013 [10]

China

Colonic

259

211

470

Hb < 8 g/dL

OS, postoperative complications

7

8 Talukder Y 2014 [11]

Australia

Colorectal

423

947

1370

OS, DFS, CSS, postoperative complications

8

9 Due SL 2012 [12]

Australia

Colorectal

151

654

805

CSS, postoperative complications

7

10 Jagoditsch M 2006 [13]

Australia

Rectal

471

126

597

Preoperative Hb < 8 g/dL, intraoperative bleeding > 500 mL or Hb < 10 g/dL

OS, DFS, postoperative complications

7

11 Lobaziewicz W 2008 [14]

Poland

Colorectal

122

135

257

Intraoperative bleeding > 1000 mL or Hct < 30%

RBC

OS, CSS, DFS

8

12 Kaneko M 2015 [15]

Japan

Colorectal

23

85

108

Allogeneic red blood cell

OS

8

13 Nursal TZ 2006 [16]

Turkey

Colorectal

61

272

333

Whole blood or RBC

OS

7

14 Li XX 2015 [17]

China

Colonic

614

461

1075

Hb < 6 g/dL, Hb 6–10 g/dL according to cardiopulmonary function

OS, postoperative complications

7

15 Halabi WJ 2013 [18]

USA

Colorectal

3815

23,305

27,120

RBC

OS, postoperative complications

8

16 Warschkow R 2014 [19]

Switzerland

Rectal

217

184

401

Prestored allogeneic blood

OS, DFS

7

17 Koch M 2011 [20]

Germany

Colorectal

135

396

531

Hb 8–10 g/dL according to cardiopulmonary function

Postoperative complications

7

18 Ghinea R 2013 [21]

Italy

Colorectal

68

133

201

OS, DFS, postoperative complications

7

19 Skanberg J 2007 [22]

Sweden

Colorectal

298

344

642

LDB or RBC

OS

8

20 Mynster T 2000 [23]

Denmark

Colorectal

288

452

770

SAGM and/or FFP

Postoperative complications

8

21 Patel SV 2017 [24]

Canada

Colonic

2009

5189

7198

OS, CSS

9

22 van de Watering LMG2001 [25]

Netherlands

Colorectal

446

251

697

LDB or RBC

OS

7

23 Papageorge CM 2016 [26]

England

Colorectal

2073

58,712

72,011

Whole blood or RBC

Postoperative complications

7

24 Benoist S 2001 [27]

France

Rectal

72

140

212

Hb < 8 g/dL

Postoperative complications

7

25 Jensen LS 2005 [28]

Denmark

Colorectal

249

320

569

LDB or RBC

OS, postoperative complications

9

26 Mynster T 2001 [29]

Denmark

Colorectal

452

288

740

SAGM and/or FFP

OS

7

27 Aquina CT 2016 [30]

USA

Colorectal

6927

17,303

24,230

OS, CSS, postoperative complications

8

28 Mazzeffi M 2017 [31]

USA

Colonic

1845

23,388

24,733

RBC

Postoperative complications

8

29 Van Osdol AD 2015 [32]

USA

Colorectal

110

365

475

Postoperative Hb < 7 g/dL, preoperative Hb < 8.4 g/dL

OS, DFS, postoperative complications

7

30 Sánchez-Velázquez P 2018 [33]

Spain

Colonic

  

363

DFS, CSS

8

31 Molland G 1995 [34]

Australia

Colorectal

223

210

433

All kinds of blood products

OS

8

32 Cheslyn-Curtis S 1990 [35]

UK

Colorectal

591

370

961

OS

7

33 Donohue JH 1995 [36]

USA

Colorectal

446

605

1051

Whole blood or RBC or plasma

OS

8

34 Tartter PI 1992 [37]

USA

Colorectal

110

229

329

RBC

DFS

7

35 Garau I 1994 [38]

Spain

Colorectal

348

338

686

Whole blood or RBC or plasma

OS

7

36 Edna TH 1994 [39]

Norway

Colorectal

236

100

336

Hb < 9 g/dL or bleeding > 20% blood volume

SAGM

OS

8

  1. LDB leucocyte-depleted blood products, RBC packed red blood cells, SAGM buffy coat-depleted red cells suspended in saline, adenine, glucose, and mannitol, FFP fresh-frozen plasma