Table 1 Characteristics of the trials
ID | Country | Tumour type | Sample size | Transfusion trigger | Type of blood products | Outcomes | NOS (stars) | ||
|---|---|---|---|---|---|---|---|---|---|
BT+ | BT− | Total | |||||||
1 Tarantino I 2013 [1] | Switzerland | Colonic | 148 | 161 | 309 | – | – | OS | 7 |
2 Gunka I 2013 [2] | Czech | Colorectal | 132 | 451 | 583 | – | – | OS | 7 |
3 Amri R 2017 [3] | USA | Colonic | 305 | 1118 | 1423 | – | – | OS, CSS | 8 |
4 Morner MEM 2016 [4] | Sweden | Colorectal | 199 | 297 | 496 | – | – | OS | 8 |
5 Qiu L 2015 [8] | China | Colorectal | 803 | 601 | 1404 | Hb < 6 g/dL, Hb 6–10 g/dL according to cardiopulmonary function | – | OS, postoperative complications | 7 |
6 Miki C 2006 [9] | Japan | Colorectal | 35 | 82 | 117 | – | – | OS, postoperative complications | 8 |
7 Meng J 2013 [10] | China | Colonic | 259 | 211 | 470 | Hb < 8 g/dL | – | OS, postoperative complications | 7 |
8 Talukder Y 2014 [11] | Australia | Colorectal | 423 | 947 | 1370 | – | – | OS, DFS, CSS, postoperative complications | 8 |
9 Due SL 2012 [12] | Australia | Colorectal | 151 | 654 | 805 | – | – | CSS, postoperative complications | 7 |
10 Jagoditsch M 2006 [13] | Australia | Rectal | 471 | 126 | 597 | Preoperative Hb < 8 g/dL, intraoperative bleeding > 500 mL or Hb < 10 g/dL | – | OS, DFS, postoperative complications | 7 |
11 Lobaziewicz W 2008 [14] | Poland | Colorectal | 122 | 135 | 257 | Intraoperative bleeding > 1000 mL or Hct < 30% | RBC | OS, CSS, DFS | 8 |
12 Kaneko M 2015 [15] | Japan | Colorectal | 23 | 85 | 108 | – | Allogeneic red blood cell | OS | 8 |
13 Nursal TZ 2006 [16] | Turkey | Colorectal | 61 | 272 | 333 | – | Whole blood or RBC | OS | 7 |
14 Li XX 2015 [17] | China | Colonic | 614 | 461 | 1075 | Hb < 6 g/dL, Hb 6–10 g/dL according to cardiopulmonary function | – | OS, postoperative complications | 7 |
15 Halabi WJ 2013 [18] | USA | Colorectal | 3815 | 23,305 | 27,120 | – | RBC | OS, postoperative complications | 8 |
16 Warschkow R 2014 [19] | Switzerland | Rectal | 217 | 184 | 401 | – | Prestored allogeneic blood | OS, DFS | 7 |
17 Koch M 2011 [20] | Germany | Colorectal | 135 | 396 | 531 | Hb 8–10 g/dL according to cardiopulmonary function | – | Postoperative complications | 7 |
18 Ghinea R 2013 [21] | Italy | Colorectal | 68 | 133 | 201 | – | – | OS, DFS, postoperative complications | 7 |
19 Skanberg J 2007 [22] | Sweden | Colorectal | 298 | 344 | 642 | – | LDB or RBC | OS | 8 |
20 Mynster T 2000 [23] | Denmark | Colorectal | 288 | 452 | 770 | – | SAGM and/or FFP | Postoperative complications | 8 |
21 Patel SV 2017 [24] | Canada | Colonic | 2009 | 5189 | 7198 | – | – | OS, CSS | 9 |
22 van de Watering LMG2001 [25] | Netherlands | Colorectal | 446 | 251 | 697 | – | LDB or RBC | OS | 7 |
23 Papageorge CM 2016 [26] | England | Colorectal | 2073 | 58,712 | 72,011 | – | Whole blood or RBC | Postoperative complications | 7 |
24 Benoist S 2001 [27] | France | Rectal | 72 | 140 | 212 | Hb < 8 g/dL | – | Postoperative complications | 7 |
25 Jensen LS 2005 [28] | Denmark | Colorectal | 249 | 320 | 569 | – | LDB or RBC | OS, postoperative complications | 9 |
26 Mynster T 2001 [29] | Denmark | Colorectal | 452 | 288 | 740 | – | SAGM and/or FFP | OS | 7 |
27 Aquina CT 2016 [30] | USA | Colorectal | 6927 | 17,303 | 24,230 | – | – | OS, CSS, postoperative complications | 8 |
28 Mazzeffi M 2017 [31] | USA | Colonic | 1845 | 23,388 | 24,733 | – | RBC | Postoperative complications | 8 |
29 Van Osdol AD 2015 [32] | USA | Colorectal | 110 | 365 | 475 | Postoperative Hb < 7 g/dL, preoperative Hb < 8.4 g/dL | – | OS, DFS, postoperative complications | 7 |
30 Sánchez-Velázquez P 2018 [33] | Spain | Colonic |  |  | 363 | – | – | DFS, CSS | 8 |
31 Molland G 1995 [34] | Australia | Colorectal | 223 | 210 | 433 | – | All kinds of blood products | OS | 8 |
32 Cheslyn-Curtis S 1990 [35] | UK | Colorectal | 591 | 370 | 961 | – | – | OS | 7 |
33 Donohue JH 1995 [36] | USA | Colorectal | 446 | 605 | 1051 | – | Whole blood or RBC or plasma | OS | 8 |
34 Tartter PI 1992 [37] | USA | Colorectal | 110 | 229 | 329 | – | RBC | DFS | 7 |
35 Garau I 1994 [38] | Spain | Colorectal | 348 | 338 | 686 | – | Whole blood or RBC or plasma | OS | 7 |
36 Edna TH 1994 [39] | Norway | Colorectal | 236 | 100 | 336 | Hb < 9 g/dL or bleeding > 20% blood volume | SAGM | OS | 8 |