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Table 1 Five trials recruiting patients with colorectal liver metastases for liver transplantation

From: Living donor liver transplantation with two-stage hepatectomy for patients with isolated, irresectable colorectal liver—the LIVER-T(W)O-HEAL study

  RAPID SECA-II    LIVER-T(W)O-HEAL
NCT02215889 NCT01479608 NCT02597348 NCT02864485 NCT03488953
Country Norway Norway France Canada Germany
Center(s) Oslo Oslo Paris, Paul-Brousse- Hospital Toronto Jena and Tübingen
Start 6/2014 2011 10/2015 8/2016 3/2018
State Recruiting Recruiting Recruiting Recruiting Recruiting
Planned number of included patients 20 25 90 20 40
Inclusion criteria More than 8 weeks of systemic therapy
More than 12 months after resection of the primary tumor.
More than 6 weeks of systemic therapy
More than 12 months after resection of the primary tumor.
Metachronous metastasis > 12 months after resection of the primary tumor
Initial lymph node state:
pN0
CEA:
<  100
At least “stable disease” after 3 months of systemic therapy.
More than 12 months after resection of the primary tumor.
BRAF wild-type
At least “stable disease” during systemic therapy.
State of the primary tumor:
<pT3, N1
More than 6 months after resection of the primary tumor.
BRAF wild-type
At least “stable disease” after 8 weeks of systemic therapy.
State of the primary tumor:
<pT3, N1
Mode of transplantation Deceased donation.
Left lateral split (segment II/III).
Two-stage hepatectomy.
Deceased donation, whole organ Deceased donation, whole organ Living donation, right liver lobe Living donation
Left lateral split (segment II/III)
Two-stage hepatectomy
Primary endpoint Overall survival, recurrence-free survival, technical feasibility. Overall survival, recurrence-free survival Overall survival, recurrence-free survival Overall survival, recurrence-free survival Overall survival, recurrence-free survival, technical feasibility