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Table 2 Cox proportional hazards regression model multivariate analysis of the overall survival and breast cancer-specific survival in PR-positive cohort (forward: LR)

From: Characterization and prognosis of estrogen receptor-positive/progesterone receptor-negative male breast cancer: a population-based study

Variables OS BCSS
HR (95% CI) P value HR (95% CI) P value
Age at diagnosis
 ≤ 40 Reference   Reference  
 41–55 1.143 (0.729–1.791) 0.56 1.245 (0.761–2.035) 0.383
 56–70 1.633 (1.056–2.525) 0.027 1.245 (0.768–2.017) 0.374
 71–85 3.695 (2.391–5.709) < 0.001 1.693 (1.032–2.776) 0.037
 > 85 7.501 (4.678–12.029) < 0.001 2.167 (1.123–4.182) 0.021
Race
 White Reference   Reference  
 Black 1.290 (1.069–1.557) 0.008 1.453 (1.129–1.869) 0.004
 Other 0.874 (0.662–1.156) 0.346 0.959 (0.628–1.466) 0.848
 Unknown 0.862 (0.348–2.138) 0.749 0.000 (0.000–8.644E+62) 0.905
Marital status
 Married Reference   Reference  
 Not married 1.589 (1.397–1.808) < 0.001 1.508 (1.243–1.829) < 0.001
 Unknown 1.318 (0.957–1.814) 0.08 1.156 (0.690–1.938) 0.582
Grade
 I Reference   Reference  
 II 1.250 (0.996–1.568) 0.054 2.136 (1.297–3.519) 0.003
 III/IV 1.470 (1.162–1.858) 0.001 2.775 (1.675–4.596) < 0.001
 Unknown 1.175 (0.875–1.578) 0.283 2.493 (1.412–4.401) 0.002
Tumor size
 T1 Reference   Reference  
 T2 1.565 (1.450–1.911) < 0.001 1.953 (1.567–2.435) < 0.001
 T3 1.858 (1.395–2.475) < 0.001 1.746 (1.161–2.626) 0.007
 T4 1.890 (1.490–2.397) < 0.001 2.636 (1.863–3.728) < 0.001
 TX 0.873 (0.588–1.296) 0.501 0.981 (0.549–1.753) 0.948
Nodal status
 N0 Reference   Reference  
 N1 1.655 (1.426–1.922) < 0.001 2.317 (1.829–2.935) < 0.001
 N2 1.931 (1.558–2.395) < 0.001 2.713 (2.002–3.677) < 0.001
 N3 2.362 (1.879–2.968) < 0.001 4.075 (3.022–5.495) < 0.001
 NX 2.348 (1.741–3.168) < 0.001 2.194 (1.355–3.553) 0.001
Metastasis
 M0 Reference   Reference  
 M1 2.952 (2.348–3.713) < 0.001 5.412 (4.075–7.189) < 0.001
Surgery
 Done Reference   Reference  
 Not 2.350 (1.766–3.127) < 0.001 2.623 (1.830–3.758) < 0.001
 Unknown 1.580 (0.690–3.617) 0.279 1.692 (0.646–4.428) 0.284
Chemotherapy
 Yes Reference  
 No/unknown 1.261 (1.088–1.461) 0.002