Table 4 Histomorphological characteristics of GISTs
Features | Recurrence, n (%)a | Metastasis, n (%)a | ||||
|---|---|---|---|---|---|---|
Yes | No | P value (P < 0.05) | Yes | No | P value (P < 0.05) | |
Location | 1.000 | 0.305 | ||||
Gastrointestinal | 5 (100.0) | 54 (94.7) | 16 (88.9) | 45 (95.7) | ||
Extra-gastrointestinal | 0 (0.0) | 3 (5.3) | 2 (11.1) | 2 (4.3) | ||
Tumor size | 0.122 | 0.023 | ||||
≤ 10 cm | 2 (40.0) | 43 (75.4) | 9 (50.0) | 37 (78.8) | ||
> 10 cm | 3 (60.0) | 14 (24.6) | 9 (50.0) | 10 (21.3) | ||
Tumor focalty | 1.000 | 1.000 | ||||
Unifocal | 5 (100.0) | 52 (94.5) | 16 (94.1) | 44 (95.7) | ||
Multifocal | 0 (0.0) | 3 (5.5) | 1 (5.9) | 2 (4.3) | ||
Histomorphological type | 0.622 | 0.027 | ||||
Spindled cell type | 3 (60.0) | 41 (71.9) | 9 (50.0) | 38 (80.9) | ||
Epithelioid type and mixed type | 2 (40.0) | 16 (28.1) | 9 (50.0) | 9 (19.1) | ||
Histomorphological subtype | 1.000 | 0.114 | ||||
Diffuse hypercellularity subtype | 3 (75.0) | 39 (70.9) | 14 (87.5) | 29 (64.4) | ||
Palisade-vacuolated subtype | 1 (25.0) | 16 (29.1) | 2 (12.5) | 16 (35.6) | ||
Mitotic count | 0.099 | 0.000 | ||||
≤ 5/5 mm2 | 2 (40.0) | 42 (77.8) | 4 (28.6) | 41 (87.2) | ||
> 5/5 mm2 | 3 (60.0) | 12 (22.2) | 10 (71.4) | 6 (12.8) | ||
Microscopic arrangement | 0.376 | 0.05 | ||||
Solid | 4 (80.0) | 31 (54.4) | 13 (76.5) | 23 (48.9) | ||
Interlacing-bundled | 1 (20.0) | 26 (45.6) | 4 (23.5) | 24 (51.1) | ||
Cellularity | 1.000 | 0.257 | ||||
High | 3 (60.0) | 32 (56.1) | 12 (66.7) | 24 (51.1) | ||
Moderate-low | 2 (40.0) | 25 (43.9) | 6 (33.3) | 23 (48.9) | ||
Nuclear atypia | 0.855 | 0.329 | ||||
High | 0 (0.0) | 3 (5.3) | 1 (5.6) | 2 (4.3) | ||
Intermediate | 1 (20.0) | 9 (15.8) | 5 (27.8) | 6 (12.8) | ||
Low | 4 (80.0) | 45 (78.9) | 12 (66.7) | 39 (83.0) | ||
Cytoplasmic appearance | 0.641 | 0.098 | ||||
Eosinophilic | 3 (60.0) | 23 (40.4) | 11 (61.1) | 18 (38.3) | ||
Mixed | 2 (40.0) | 34 (59.6) | 7 (38.9) | 29 (61.7) | ||
Skeinoid fibers | 1 (20.0) | 3 (6.7) | 0.353 | 2 (25.0) | 2 (4.8) | 0.115 |
Rhabdoid appearance | 0 (0.0) | 4 (8.9) | 1.000 | 1 (12.5) | 3 (7.1) | 0.514 |
Myxoid change | 2 (40.0) | 2 (4.4) | 0.045 | 3 (37.5) | 1 (2.4) | 0.011 |
Sclerotic stroma | 1 (20.0) | 3 (6.7) | 0.353 | 1 (12.5) | 3 (7.1) | 0.514 |
Intratumoral lymphocytic infiltrations | 1 (20.0) | 2 (4.4) | 0.276 | 0 (0.0) | 3 (7.1) | 1.000 |
Peritumoral lymphocytic aggregation | 1 (20.0) | 6 (13.3) | 0.546 | 1 (12.5) | 6 (14.3) | 1.000 |
Hyalinized blood vessels | 1 (20.0) | 1 (2.2) | 0.192 | 0 (0.0) | 2 (4.8) | 1.000 |
Calcification | 0 (0.0) | 7 (15.2) | 1.000 | 0 (0.0) | 7 (16.3) | 0.579 |
Hemorrhage | 4 (80.0) | 28 (58.3) | 0.637 | 7 (70.0) | 25 (58.1) | 0.722 |
Intranuclear inclusion | 0 (0.0) | 7 (15.2) | 1.000 | 2 (22.2) | 5 (11.9) | 0.592 |
Mucosal invasion | 1 (20.0) | 13 (27.7) | 1.000 | 7 (70.0) | 7 (16.7) | 0.002 |
Muscular invasion | 3 (60.0) | 28 (60.9) | 1.000 | 6 (75.0) | 25 (58.1) | 0.456 |
Coagulative necrosis | 4 (80.0) | 18 (36.7) | 0.146 | 8 (66.7) | 14 (33.3) | 0.051 |