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Table 3 Multivariate analyses of factors affecting overall survival across BCLC stage

From: Ability of the ALBI grade to predict posthepatectomy liver failure and long-term survival after liver resection for different BCLC stages of HCC

Variable

Multivariable Cox regression

Total cohort

BCLC 0/A

BCLC B/C

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Age, years

1.03 (0.72ā€“1.48)

0.868

1.08 (0.61ā€“1.93)

0.791

0.79 (0.49ā€“1.29)

0.343

Male gender

0.86 (0.53ā€“1.40)

0.541

1.10 (0.51ā€“2.37)

0.803

0.85 (0.44ā€“1.65)

0.626

Platelet count, Ɨā€‰109/l

1.62 (1.10ā€“2.38)

0.014

1.90 (1.02ā€“3.53)

0.043

1.26 (0.75ā€“2.11)

0.383

Prothrombin time, sec

1.00 (0.89ā€“1.12)

0.938

0.92 (0.76ā€“1.11)

0.362

1.07 (0.92ā€“1.25)

0.379

Serum AFP, ng/ml

1.09 (0.80ā€“1.49)

0.594

1.22 (0.72ā€“2.05)

0.457

0.92 (0.61ā€“1.39)

0.677

Tumor size, cm

1.71 (1.21ā€“2.44)

0.003

1.95 (1.15ā€“3.32)

0.014

1.58 (0.95ā€“2.64)

0.079

ALBI score

1.62 (1.18ā€“2.22)

0.003

2.29 (1.39ā€“3.78)

0.001

1.42 (0.91ā€“2.20)

0.122

Major hepatectomy

1.33 (0.93ā€“1.88)

0.115

1.02 (0.53ā€“1.95)

0.965

1.33 (0.86ā€“2.08)

0.201

MVI

2.10 (1.49ā€“2.97)

<ā€‰0.001

1.91 (1.13ā€“3.01)

0.028

1.53 (0.89ā€“2.83)

0.046

Differentiation grade

1.69 (1.24ā€“2.30)

0.001

1.77 (1.08ā€“2.89)

0.024

2.03 (1.28ā€“3.23)

0.003

MELD score

0.98 (0.90ā€“1.08)

0.727

0.98 (0.84ā€“1.15)

0.803

1.00 (0.88ā€“1.14)

0.989

  1. HR hazard ratio, CI confidence interval, BCLC Barcelona Clinic Liver Cancer, AFP Ī±-fetoprotein, ALBI albumin-bilirubin, MVI microvascular invasion, MELD model for end-stage liver disease