Table 3 Postoperative RT III clinical trials, toxic reactions, and target volume
From: Progress of preoperative and postoperative radiotherapy in gastric cancer
Study/institute | RT dose (Gy) | Intervention | Severe toxicity | Target volume | Completed rate |
|---|---|---|---|---|---|
2001 INT0116 USA [3] | 45 | CRT, 45Gy, 5FU+LV | Grade 3+, 41%, Grade 4+,32% | Tumor bed, regional node (nos. 1–16) | 63% |
2012 ARTIST South Korea [24] | 45 | CT-CRT-CT, CRT: Capecitabine; CT: XP | Similar to chemotherapy alone | Tumor bed in T4 LN (nos. 7–9 and 12–16) | 82% |
2012 NCC South Korea [26] | 45 | CRT, 5FU+LV | Grade 3+ hematologic toxicities; 20% vs. 25% G3+GI; 17% vs. 11% | Tumor bed, regional node (nos. 1–16) | 87% |
2012 IMRT China [27] | 45 | CRT, 45Gy, 5FU+LV | Similar toxicity mostly well tolerated | Tumor bed, regional node (nos. 1–16) | 91% |