Modified RECIST 1.1[13] | Modified EORTC [12] | ICDS [14] | |
---|---|---|---|
CR | Disappearance of all target lesions; all target lymph nodes are < 10 mm in the short axis | Complete resolution of abnormal 18FDG uptake within the tumor volume of all target lesions to a level that is indistinguishable from surrounding normal tissue | Disappearance of all disease |
PR | At least a 30% decrease in SLD using baseline SLD as a reference | Reduction of the sum of the SUVmax by ≥ 15–25% after 1 cycle and a decrease of ≥ 25% compared with baseline after > 1 treatment cycle | A decrease in size (%Δ Choi SLD) ≥ 10% or an increase in CT density > 15% compared with baseline, no new lesions, and no obvious progression of nonmeasurable disease |
SD | Neither sufficient shrinkage of target lesions to qualify for PR nor sufficient increase to qualify for PD, taking as reference the nadir SLD | %ΔΣ SUVmax increased by < 25% or decreased by < 15% compared with baseline and no visible extent of 18FDG tumor uptake (> 20% in the longest dimension) | Does not meet the criteria for CR, PR, or PD; no symptomatic deterioration attributed to tumor progression |
PD | At least a 20% increase in the SLD of target lesions, taking as reference the nadir SLD; in addition to the relative increase of 20% in SLD, the SLD must also demonstrate an absolute increase of ≥ 5 mm | %ΔΣ SUVmax increased by ≥ 25% compared with baseline scan, visible increase in the extent of 18FDG uptake (> 20% in the longest dimension) or the appearance of new 18FDG uptake in metastatic lesions | An increase in unidimensional tumor size (Choi SLD) ≥ 10% and does not meet the criteria for PR using CT density; any new lesions identified by CT/MRI; new intratumoral nodules or increase in the size of existing intratumoral nodules |
UE | A target lesion present at baseline that subsequently became UE | 18FDG-PET exam was unavailable or deemed UE;a response will be UE unless unequivocal PD is determined on the basis of the evaluable target lesion | The CT/MRI exam is unavailable or deemed UE; if a target lesion is deemed UE by density and size measurement and the rules for PD do not apply, a response of CR, PR, or SD cannot be assigned for the time point and the response will be UE |