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Table 3 Hub genes in the PPI networks

From: Prediction of key genes and pathways involved in trastuzumab-resistant gastric cancer

Gene symbols Gene names Degrees Betweenness centrality
CD44 CD44 molecule 68 0.11543115
ERBB2 erb-b2 receptor tyrosine kinase 2 53 0.07513542
CDH1 cadherin 1 52 0.07282977
OAS1 2′-5′-oligoadenylate synthetase 1 52 0.01778379
OAS2 2′-5′-oligoadenylate synthetase 2 52 0.01854906
OAS3 2′-5′-oligoadenylate synthetase 3 51 0.01691589
OASL 2′-5′-oligoadenylate synthetase-like 50 0.01635114
ISG15 ISG15 ubiquitin-like modifier 49 0.02075018
BMP4 Bone morphogenetic protein 4 46 0.04507158
STAT1 Signal transducer and activator of transcription 1 43 0.03737542
EGR1 Early growth response 1 42 0.04589496
CCND1 Cyclin D1 41 0.03727744
VIM Vimentin 40 0.06221522
WNT5A Wnt family member 5A 39 0.04301014
KIT KIT proto-oncogene receptor tyrosine kinase 37 0.03489184
BMP2 Bone morphogenetic protein 2 35 0.02672618
IRF9 Interferon regulatory factor 9 35 0.00398764
MX1 MX dynamin-like GTPase 1 35 0.00512151
FYN FYN proto-oncogene, Src family tyrosine kinase 34 0.05255568
HERC6 HECT and RLD domain containing E3 ubiquitin-protein ligase family member 6 34 0.02783539