Prediction of key genes and pathways involved in trastuzumab-resistant gastric cancer

Table 3 Hub genes in the PPI networks

Gene symbols	Gene names	Degrees	Betweenness centrality
CD44	CD44 molecule	68	0.11543115
ERBB2	erb-b2 receptor tyrosine kinase 2	53	0.07513542
CDH1	cadherin 1	52	0.07282977
OAS1	2′-5′-oligoadenylate synthetase 1	52	0.01778379
OAS2	2′-5′-oligoadenylate synthetase 2	52	0.01854906
OAS3	2′-5′-oligoadenylate synthetase 3	51	0.01691589
OASL	2′-5′-oligoadenylate synthetase-like	50	0.01635114
ISG15	ISG15 ubiquitin-like modifier	49	0.02075018
BMP4	Bone morphogenetic protein 4	46	0.04507158
STAT1	Signal transducer and activator of transcription 1	43	0.03737542
EGR1	Early growth response 1	42	0.04589496
CCND1	Cyclin D1	41	0.03727744
VIM	Vimentin	40	0.06221522
WNT5A	Wnt family member 5A	39	0.04301014
KIT	KIT proto-oncogene receptor tyrosine kinase	37	0.03489184
BMP2	Bone morphogenetic protein 2	35	0.02672618
IRF9	Interferon regulatory factor 9	35	0.00398764
MX1	MX dynamin-like GTPase 1	35	0.00512151
FYN	FYN proto-oncogene, Src family tyrosine kinase	34	0.05255568
HERC6	HECT and RLD domain containing E3 ubiquitin-protein ligase family member 6	34	0.02783539

ISSN: 1477-7819