From: Schwannoma of the colon and rectum: a systematic literature review
Study | Age | G | Symptoms | S | Location | Colonoscopy and imaging | Diagnosis | Surgery/LN | (Antonini) S-100 +/mitosis |
---|---|---|---|---|---|---|---|---|---|
Tsunoda [1] | 67 | F | FOB | 3 | Transverse | Ulcerated S-M/ CT: well circumscribed, homogenous enhancement, EUS: hypo-echoic S-M | Post-Sur | Open/− | NSE/MIB-1 low |
Nonose [2] | 71 | F | Tenesmus | 3 | Sigmoid | Ulcerated S-polyp | Biopsy | Lap/− | (A)Ki67 < 5% |
Miettinem [4] 20 | 82 | M | NA | 0.5 | Rectum | S-M/NA | Biopsy | Endoscopy/NA | Mitosis 0/50 |
30 | F | FOB | 1.5 | Sigmoid | S-M/NA | Biopsy | Endoscopy/NA | Mitosis 2/50 | |
83 | M | NA | 2.3 | Cecum | NA | Post-Sur | Open/NA | Mitosis 1/50 | |
64 | F | Asymptomatic | 2.5 | Transverse | NA | Post-Sur | Open/NA | Mitosis 1/50 | |
62 | M | Rectorrhagia | 2.5 | Left | NA | Post-Sur | Open/NA | Mitosis 0/50 | |
65 | M | Asymptomatic | 2.8 | Cecum | Cecal mass/NA | Post-Sur | Open/NA | Mitosis 0/50 | |
80 | F | NA | 3 | Sigmoid | S-polyp/NA | Post-Sur | Open/NA | Mitosis 1/50 | |
71 | F | Rectorrhagia | 3 | Cecum | NA | Post-Sur | Open/NA | Mitosis 0/50 | |
58 | M | Rectorrhagia | 3 | Transverse | NA | Biopsy | Open/NA | Mitosis 0/50 | |
57 | F | Rectorrhagia | 3 | Sigmoid | S-M/NA | Post-Sur | Open/NA | Mitosis 1/50 | |
84 | F | Asymptomatic | 3.9 | Cecum | NA | Biopsy | Openb/NA | Mitosis 0/50 | |
87 | M | NA | 4 | NA | NA | Post-Sur | NA | Mitosis 5/50 | |
75 | F | Constipation | 4 | Transverse | S-M/NA | Post-Sur | Open/NA | Mitosis 1/50 | |
18 | F | Intussusception | 5 | Cecum | S-M/NA | Post-Sur | Open/NA | Mitosis 3/50 | |
72 | M | NA | 5.5 | Cecum | S-M/NA | Post-Sur | Open/NA | Mitosis 0/50 | |
55 | M | NA | 0.7 | Sigmoid | S-M/NA | Post-Sur | Open/NA | Mitosis 0/50 | |
58 | F | NA | 0.8 | Sigmoid | NA | Post-Sur | Open/NA | Mitosis 0/50 | |
72 | M | Weight lossa | 1 | Sigmoid | S-polyp/NA | Biopsy | Endoscopy/NA | Mitosis 0/50 | |
61 | F | Ulcer symptoms | 5 | Sigmoid | NA | Post-Sur | Open/NA | Mitosis 0/50 | |
23 | F | Asymptomatic | 5.5 | Sigmoid | NA | Post-Sur | Open/NA | Mitosis 1/50 | |
Barbeiro [5] | 49 | F | Asymptomatic | 3 | Right | S-M/CT: well circumscribed, homogenous enhancement | Post-Sur | Open/− | Low mitosis |
Jung [6] | 59 | F | Rectorrhagia | 4.8 | Sigmoid | Fungating mass/CT: enlarged LN, FDG-PET: Hyper | Post-Sur | Open/− | Mitosis < 1/10 |
Park [7] 2 | 52 | F | NA | 1.3 | Right | S-M/CT: well circumscribed, homogenous enhancement | Post-Sur | Lap/NA | NA |
59 | F | Asymptomatic | 1.5 | Left | S-M/CT: well circumscribed | Post-Sur | Lap/NA | NA | |
Hornick [8] | 48 | M | NA | 5 | NA | NA | NA | NA | NA |
Akgul [9] | 57 | F | Tenesmus | 6.5 | Rectum | S-M/ CT: isodense + central necrosis | Post-Sur | Open/NA | NA |
Wang [10] | 62 | F | Rectorrhagiaa | 4 | Right | S-polyp/CT: well circumscribed, homogenous low enhancement | Post-Sur | Open/NA | (A) Ki-67 < 3% |
Tashiro [11] | 64 | F | Asymptomatic | 5 | Right | S-M/CT: well circumscribed, homogenous enhancement | Post-Sur | Lap/− | MIB-1 < 5% |
Suzuki [12] | 70 | F | Asymptomatic | 18 | Rectum | S-M/ MRI: hypo T1- hyper T2, EUS: hypo-echoic S-M | Post-Sur | Transanal μ/NA | < 1/10 |
Bugiantella [13] | 65 | M | FOB | 2.5 | Sigmoid | S-M/ EUS: hypo-echoic S-M | Post-Sur | Lap/− | Vimentin/Ki-67 < 2% |
De Mesquita [14] | 79 | F | Weight lossa | 10 | Cecum | NA/CT: well circumscribed, homogenous low enhancement | Post-Sur | Open/NA | Vimentin/NA |
Vasilakaki [15] | 68 | M | Rectorrhagia | 4 | Right | S-M/NA | Post-Sur | Open/− | NA |
Kanneganti [16] | 35 | F | Melenaa | 4 | Cecum | Ulcerated S-M/CT: mass | Post-Sur | Open/NA | low |
Goh [17] 2 | 54 | F | Abdominal pain | 3 | Right | Obstructing mass/NA | Post-Sur | Open/NA | NA |
41 | F | Rectorrhagia | 2.9 | Rectum | S-M/EUS: S-M | Post-Sur | Transanal/NA | NA | |
Inagawa [18] 2 | 73 | F | Rectorrhagiaa | 3.5 | Sigmoid | Hard ulcerated S-M/CT: high density | Post-Sur | Open/NA | (A)vimentin, GFAP/NA |
44 | M | FOB | 1 | Cecum | S-M/NA | Biopsy | Endoscopy/NA | (A) vimentin, GFAP/NA | |
Turaihi [19] | 61 | F | Rectorrhagia | 4 | Cecum | S-M/CT: mass | Post-Sur | Lap/− | NA |
Uhr [20] | 73 | F | Asymptomatic | 3.1 | Left | S-M/CT: mass + enlarged LN | Post-Sur | Lap/NA | (A)NA |
Meeks [21] | 95 | F | Obstruction | 1 | Appendix | NA | Post-Sur | Open/NA | NA |
Terada [22] | 52 | M | Asymptomatic | 0.9 | NA | S-M | Biopsy | Endoscopy/NA | NA |
Çakir [23] | 79 | F | Rectorrhagia | 5 | Sigmoid | Rough ulcerated mass/CT: ulcerated mass | Post-Sur | Open/− | Vimentin/Ki-67 < 5% |
Dickson [24] | 72 | M | Rectorrhagiaa | Cecum | S-M/CT: mass | Post-Sur | Open/NA | (A, B) NA | |
Tokuhara [25] | 74 | F | FOB | 3 | Sigmoid | S-M/EUS: hypo-echoic S-M | Post-Sur | Lap/NA | (A)MIB-1 < 3% |
Baskaran [26] | 49 | M | FOB | Pancolic | S-M/NA | Biopsy | Endoscopy/NA | NA | |
Verdu-Fernandez [27] | 67 | M | Asymptomatic | 4.5 | Left | NA/CT: mass with enlarged LN, US: intussusception | Post-Sur | Open/NA | CD68 |
Baek [28] | 70 | F | Asymptomatic | 2 | Cecum | Polyp/CT: polyp with low attenuation | Post-Sur | Lap/NA | (A) CD34/ Ki-67 < 5% |
Petrie [29] | 25 | M | Bloody diarrheaa | 4 | Sigmoid | Friable mucosa/CT: obstructing mass | Post-Sur | Open/NA | (A)NA |
Shelat [30] | 63 | F | Anorexiaa | Rectum | S-polyp/CT: polyp | Post-Sur | Open/− | NA | |
Trivedi [31] | 61 | M | NA | 1.3 | Sigmoid | S-polyp/NA | Post-Sur | Endoscopy/NA | CD34/MIB-1 < 2% |
Kawaguchi [32] | 77 | F | Tenesmus | 1 | Rectum | S-M/EUS: hypoechoic, CT: mass | Biopsy | Endoscopy/NA | (A) mitosis < 1/10 |
Tan [33] | 63 | F | Early satiety | 3 | Rectum | S-polyp/MRI: mass | Post-Sur | Open/ NA | NA |
Yang [34] 2 | 27 | F | Rectorrhagia | 3 | Rectum | S-M/NA | Post-Sur | NA | NA |
53 | M | Asymptomatic | 2 | Sigmoid | S-M/NA | Post-Sur | NA | NA | |
Matsumoto [35] | 59 | F | Asymptomatic | 2 | Cecum | S-M/CT: well circumscribed, homogenous enhancement | Post-Sur | Lap wedge/NA | Vimentin/ MIB-1 < 2% |
Kim [36] | 61 | M | Asymptomatic | 1.8 | Right | Polypoid/CT: well circumscribed, homogenous enhancement | Biopsy | Lap/NA | NA |
Vijayasekaran [37] | 75 | F | Asymptomatic | 3.2 | Rectum | NA/EUS: S-M, CT: enlarged LN | Post-Sur | Open | NA |
Wu [38] | 84 | M | NA | Rectum | NA: FDG PET: hyper | Post-Sur | NA | NA | |
Tedeschi [39] | 80 | M | Rectorragia | 4 | Rectum | S-polyp/CT: mass | Post-Sur | Open/NA | (A)mitosis < 1/10 |
Tanaka [40] | 70 | F | FOB | Left | Ulcerated S-M/CT: well circumscribed, homogenous enhancement | Post-Sur | Open/NA | (A,B)NA | |
Rocco [41] | 67 | F | Asymptomatic | 0.3 | Left | S-polyp/NA | Biopsy | Endoscopy/NA | NA |
Wani [42] | 75 | F | Abdominal pain | 5 | Right | S-polyp/NA | Post-Sur | Open/NA | NA |
Kienemud [43] 2 | 70 | F | Asymptomatic | 0.7 | Sigmoid | S-M/NA | Post-Sur | Open/NA | (B)NA |
70 | M | Asymptomatic | 1.3 | Sigmoid | S-polyp/NA | Biopsy | Endoscopy/NA | (B)NA | |
Hsu KF [44] | 88 | F | Constipation | 3.5 | Rectum | S-M/EUS: hypoechoic, CT: no enlarged LN | Post-Sur | Transanal/NA | (A,B)NA |
Wilde [45] | 68 | F | Explosive diarrhea, | 1.5 | Sigmoid | NA | Post-Sur | Open/− | (B)vimentin, GFAP/NA |
Mysorekar [46] | 33 | M | Abdominal pain | 3.5 | Right | S-polyp | Post-Sur | Endoscopy/NA | (A,B)NA |
Lee [47] | 32 | F | Constipation | 1.4 | Right | S-polyp | Biopsy | Endoscopy/NA | NA |
Chetty [48] | 43 | F | Asymptomatic | NA | S-polyp | Biopsy | Endoscopy/NA | HMB-45, Melan-A/NA | |
Brauman [49] | 55 | M | Constipation | 5 | Right | S-polyp/CT: mass with enlarged LN | Post-Sur | Open/NA | Β-catenin, CD117/MIB-1 < 5% |
Zippi [50] | 72 | M | Abdominal pain | 1.5 | Rectum | S-M/NA | Biopsy | Endoscopy/NA | (A,B) NA |
Hsu CT [51] | 68 | M | Abdominal pain | 3.5 | Left | S-M/ CT: well circumscribed, low homogenous enhancement, | Post-Sur | Open/NA | NA |
Emanuel [52] | 48 | M | Rectorrhagia | 4.9 | Left | Obstructing mass/CT: intussusception | Post-Sur | Open/NA | (A)EMA, CD34, vimentin/NA |
Fotiadis [53] | 55 | M | Rectorrhagia | Sigmoid | S-M/CT: no metastasis | Post-Sur | Open/NA | (B)NA | |
Bhardwaj [54] | 35 | F | Tenesmus | 2.3 | Rectum | Mass/NA | Post-Sur | Open/NA | (A)GFAP/NA |
Jacobson [55] | 56 | F | Asymptomatic | 1.7 | Sigmoid | S-M/NA | Post-Sur | Open/NA | (A)mitosis < 1/10 |
Maciejewski [56] | 67 | F | Abdominal pain | 8 | Rectum | S-M/US: large exophytic mass | Post-Sur | Open wedge/NA | (A)vimentin/NA |
Matsushita [57] | 79 | M | NA | Transverse | S-M | Biopsy | Endoscopy/NA | NA | |
Horio [58] | 66 | M | FOB | 3 | Sigmoid | S-M | Post-Sur | Open/NA | Vimentin/NA |
Sasatomi [59] | 68 | F | Rectorrhagia | 4.7 | Sigmoid | S-M/CT: mass | Post-Sur | Open/− | NA |
Prévot [60] | 74 | M | NA | 2 | Right | NA | Post-Sur | Open/NA | Vimentin, NSE/NA |
Tomozawa [61] | 66 | M | Asymptomatic | 3.5 | Right | Polypoid mass/CT: no enlarged LN | Biopsy | Open/NA | (A,B)vimentin/mitosis < 1/80 |
Skopelitou [62] | 69 | F | Rectorrhagia | 3.5 | Left | Polypoid mass/barium enema: obstruction | NA | Open/NA | GFAP, leu7/mitosis < 3/10 |
Kakizoe [63] | 72 | M | Asymptomatic | 1.5 | Rectum | S-M/NA | Post-Sur | Transanal μ/NA | (A)NA |
Murakami [64] | 75 | M | Asymptomatic | 2.2 | Rectum | Ulcerated S-M/NA | Biopsy | Transanal/NA | NA |
Sugimura [65] | 14 | M | Melena | Sigmoid | NA/barium enema: mass, CT: mass of soft tissue | Post-Sur | Open/NA | (A)vimentin/NA | |
Abe [66] 2 | 52 | M | Protruding mass | 1.5 | Rectum | S-M | Biopsy | Transanal/NA | (A)NA |
52 | F | Rectal discomfort | 4.5 | Rectum | Polyp | Biopsy | Transanal/NA | (B)NA | |
Schwartz [67] | 18 | F | ↗ Abdominal girth | 28 | Sigmoid | NA | Post-Sur | Open/NA | (A)NA (malignant) |
Cleveland [68] | 60 | F | ↗ Abdominal girth | 20 | Transverse | NA/abdominal X-ray: large mass aortogram | Post-Sur | Open/NA | NA |
Bodner [69] | 63 | F | Constipation | Rectum | Recurrence, malignant transformation | Biopsy | Abdominal | Malignant | |
Wang CL [70] | 77 | F | NA | 2.4 | Cecum | NA/CT: well circumscribed, low homogenous enhancement FDG PET: hyper | Biopsy | Open/NA | (A,B)NA |
Catania [71] | 41 | M | Tenesmus | 8 | Rectum | NA/heterogenous large mass | Post-surg | Open/− | c-Kit/NA Malignant |
Present case | 70 | F | Asymptomatic | 2 | Cecum | S-M/CT: well circumscribed, homogenous enhancement, FDG PET: hypo, Octreo PET: hypo | Post-Sur | Openwedge/− | < 1/10 |