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Table 1 Schwannomas of the colon and rectum: clinical and histopathologic characteristics of published case reports

From: Schwannoma of the colon and rectum: a systematic literature review

Study

Age

G

Symptoms

S

Location

Colonoscopy and imaging

Diagnosis

Surgery/LN

(Antonini) S-100 +/mitosis

Tsunoda [1]

67

F

FOB

3

Transverse

Ulcerated S-M/ CT: well circumscribed, homogenous enhancement, EUS: hypo-echoic S-M

Post-Sur

Open/−

NSE/MIB-1 low

Nonose [2]

71

F

Tenesmus

3

Sigmoid

Ulcerated S-polyp

Biopsy

Lap/−

(A)Ki67 < 5%

Miettinem [4]

20

82

M

NA

0.5

Rectum

S-M/NA

Biopsy

Endoscopy/NA

Mitosis 0/50

30

F

FOB

1.5

Sigmoid

S-M/NA

Biopsy

Endoscopy/NA

Mitosis 2/50

83

M

NA

2.3

Cecum

NA

Post-Sur

Open/NA

Mitosis 1/50

64

F

Asymptomatic

2.5

Transverse

NA

Post-Sur

Open/NA

Mitosis 1/50

62

M

Rectorrhagia

2.5

Left

NA

Post-Sur

Open/NA

Mitosis 0/50

65

M

Asymptomatic

2.8

Cecum

Cecal mass/NA

Post-Sur

Open/NA

Mitosis 0/50

80

F

NA

3

Sigmoid

S-polyp/NA

Post-Sur

Open/NA

Mitosis 1/50

71

F

Rectorrhagia

3

Cecum

NA

Post-Sur

Open/NA

Mitosis 0/50

58

M

Rectorrhagia

3

Transverse

NA

Biopsy

Open/NA

Mitosis 0/50

57

F

Rectorrhagia

3

Sigmoid

S-M/NA

Post-Sur

Open/NA

Mitosis 1/50

84

F

Asymptomatic

3.9

Cecum

NA

Biopsy

Openb/NA

Mitosis 0/50

87

M

NA

4

NA

NA

Post-Sur

NA

Mitosis 5/50

75

F

Constipation

4

Transverse

S-M/NA

Post-Sur

Open/NA

Mitosis 1/50

18

F

Intussusception

5

Cecum

S-M/NA

Post-Sur

Open/NA

Mitosis 3/50

72

M

NA

5.5

Cecum

S-M/NA

Post-Sur

Open/NA

Mitosis 0/50

55

M

NA

0.7

Sigmoid

S-M/NA

Post-Sur

Open/NA

Mitosis 0/50

58

F

NA

0.8

Sigmoid

NA

Post-Sur

Open/NA

Mitosis 0/50

72

M

Weight lossa

1

Sigmoid

S-polyp/NA

Biopsy

Endoscopy/NA

Mitosis 0/50

61

F

Ulcer symptoms

5

Sigmoid

NA

Post-Sur

Open/NA

Mitosis 0/50

23

F

Asymptomatic

5.5

Sigmoid

NA

Post-Sur

Open/NA

Mitosis 1/50

Barbeiro [5]

49

F

Asymptomatic

3

Right

S-M/CT: well circumscribed, homogenous enhancement

Post-Sur

Open/−

Low mitosis

Jung [6]

59

F

Rectorrhagia

4.8

Sigmoid

Fungating mass/CT: enlarged LN, FDG-PET: Hyper

Post-Sur

Open/−

Mitosis < 1/10

Park [7]

2

52

F

NA

1.3

Right

S-M/CT: well circumscribed, homogenous enhancement

Post-Sur

Lap/NA

NA

59

F

Asymptomatic

1.5

Left

S-M/CT: well circumscribed

Post-Sur

Lap/NA

NA

Hornick [8]

48

M

NA

5

NA

NA

NA

NA

NA

Akgul [9]

57

F

Tenesmus

6.5

Rectum

S-M/ CT: isodense + central necrosis

Post-Sur

Open/NA

NA

Wang [10]

62

F

Rectorrhagiaa

4

Right

S-polyp/CT: well circumscribed, homogenous low enhancement

Post-Sur

Open/NA

(A) Ki-67 < 3%

Tashiro [11]

64

F

Asymptomatic

5

Right

S-M/CT: well circumscribed, homogenous enhancement

Post-Sur

Lap/−

MIB-1 < 5%

Suzuki [12]

70

F

Asymptomatic

18

Rectum

S-M/ MRI: hypo T1- hyper T2, EUS: hypo-echoic S-M

Post-Sur

Transanal μ/NA

< 1/10

Bugiantella [13]

65

M

FOB

2.5

Sigmoid

S-M/ EUS: hypo-echoic S-M

Post-Sur

Lap/−

Vimentin/Ki-67 < 2%

De Mesquita [14]

79

F

Weight lossa

10

Cecum

NA/CT: well circumscribed, homogenous low enhancement

Post-Sur

Open/NA

Vimentin/NA

Vasilakaki [15]

68

M

Rectorrhagia

4

Right

S-M/NA

Post-Sur

Open/−

NA

Kanneganti [16]

35

F

Melenaa

4

Cecum

Ulcerated S-M/CT: mass

Post-Sur

Open/NA

low

Goh [17]

2

54

F

Abdominal pain

3

Right

Obstructing mass/NA

Post-Sur

Open/NA

NA

41

F

Rectorrhagia

2.9

Rectum

S-M/EUS: S-M

Post-Sur

Transanal/NA

NA

Inagawa [18]

2

73

F

Rectorrhagiaa

3.5

Sigmoid

Hard ulcerated S-M/CT: high density

Post-Sur

Open/NA

(A)vimentin, GFAP/NA

44

M

FOB

1

Cecum

S-M/NA

Biopsy

Endoscopy/NA

(A) vimentin, GFAP/NA

Turaihi [19]

61

F

Rectorrhagia

4

Cecum

S-M/CT: mass

Post-Sur

Lap/−

NA

Uhr [20]

73

F

Asymptomatic

3.1

Left

S-M/CT: mass + enlarged LN

Post-Sur

Lap/NA

(A)NA

Meeks [21]

95

F

Obstruction

1

Appendix

NA

Post-Sur

Open/NA

NA

Terada [22]

52

M

Asymptomatic

0.9

NA

S-M

Biopsy

Endoscopy/NA

NA

Çakir [23]

79

F

Rectorrhagia

5

Sigmoid

Rough ulcerated mass/CT: ulcerated mass

Post-Sur

Open/−

Vimentin/Ki-67 < 5%

Dickson [24]

72

M

Rectorrhagiaa

 

Cecum

S-M/CT: mass

Post-Sur

Open/NA

(A, B) NA

Tokuhara [25]

74

F

FOB

3

Sigmoid

S-M/EUS: hypo-echoic S-M

Post-Sur

Lap/NA

(A)MIB-1 < 3%

Baskaran [26]

49

M

FOB

 

Pancolic

S-M/NA

Biopsy

Endoscopy/NA

NA

Verdu-Fernandez [27]

67

M

Asymptomatic

4.5

Left

NA/CT: mass with enlarged LN, US: intussusception

Post-Sur

Open/NA

CD68

Baek [28]

70

F

Asymptomatic

2

Cecum

Polyp/CT: polyp with low attenuation

Post-Sur

Lap/NA

(A) CD34/ Ki-67 < 5%

Petrie [29]

25

M

Bloody diarrheaa

4

Sigmoid

Friable mucosa/CT: obstructing mass

Post-Sur

Open/NA

(A)NA

Shelat [30]

63

F

Anorexiaa

 

Rectum

S-polyp/CT: polyp

Post-Sur

Open/−

NA

Trivedi [31]

61

M

NA

1.3

Sigmoid

S-polyp/NA

Post-Sur

Endoscopy/NA

CD34/MIB-1 < 2%

Kawaguchi [32]

77

F

Tenesmus

1

Rectum

S-M/EUS: hypoechoic, CT: mass

Biopsy

Endoscopy/NA

(A) mitosis < 1/10

Tan [33]

63

F

Early satiety

3

Rectum

S-polyp/MRI: mass

Post-Sur

Open/ NA

NA

Yang [34]

2

27

F

Rectorrhagia

3

Rectum

S-M/NA

Post-Sur

NA

NA

53

M

Asymptomatic

2

Sigmoid

S-M/NA

Post-Sur

NA

NA

Matsumoto [35]

59

F

Asymptomatic

2

Cecum

S-M/CT: well circumscribed, homogenous enhancement

Post-Sur

Lap wedge/NA

Vimentin/ MIB-1 < 2%

Kim [36]

61

M

Asymptomatic

1.8

Right

Polypoid/CT: well circumscribed, homogenous enhancement

Biopsy

Lap/NA

NA

Vijayasekaran [37]

75

F

Asymptomatic

3.2

Rectum

NA/EUS: S-M, CT: enlarged LN

Post-Sur

Open

NA

Wu [38]

84

M

NA

 

Rectum

NA: FDG PET: hyper

Post-Sur

NA

NA

Tedeschi [39]

80

M

Rectorragia

4

Rectum

S-polyp/CT: mass

Post-Sur

Open/NA

(A)mitosis < 1/10

Tanaka [40]

70

F

FOB

 

Left

Ulcerated S-M/CT: well circumscribed, homogenous enhancement

Post-Sur

Open/NA

(A,B)NA

Rocco [41]

67

F

Asymptomatic

0.3

Left

S-polyp/NA

Biopsy

Endoscopy/NA

NA

Wani [42]

75

F

Abdominal pain

5

Right

S-polyp/NA

Post-Sur

Open/NA

NA

Kienemud [43]

2

70

F

Asymptomatic

0.7

Sigmoid

S-M/NA

Post-Sur

Open/NA

(B)NA

70

M

Asymptomatic

1.3

Sigmoid

S-polyp/NA

Biopsy

Endoscopy/NA

(B)NA

Hsu KF [44]

88

F

Constipation

3.5

Rectum

S-M/EUS: hypoechoic, CT: no enlarged LN

Post-Sur

Transanal/NA

(A,B)NA

Wilde [45]

68

F

Explosive diarrhea,

1.5

Sigmoid

NA

Post-Sur

Open/−

(B)vimentin, GFAP/NA

Mysorekar [46]

33

M

Abdominal pain

3.5

Right

S-polyp

Post-Sur

Endoscopy/NA

(A,B)NA

Lee [47]

32

F

Constipation

1.4

Right

S-polyp

Biopsy

Endoscopy/NA

NA

Chetty [48]

43

F

Asymptomatic

 

NA

S-polyp

Biopsy

Endoscopy/NA

HMB-45, Melan-A/NA

Brauman [49]

55

M

Constipation

5

Right

S-polyp/CT: mass with enlarged LN

Post-Sur

Open/NA

Β-catenin, CD117/MIB-1 < 5%

Zippi [50]

72

M

Abdominal pain

1.5

Rectum

S-M/NA

Biopsy

Endoscopy/NA

(A,B) NA

Hsu CT [51]

68

M

Abdominal pain

3.5

Left

S-M/ CT: well circumscribed, low homogenous enhancement,

Post-Sur

Open/NA

NA

Emanuel [52]

48

M

Rectorrhagia

4.9

Left

Obstructing mass/CT: intussusception

Post-Sur

Open/NA

(A)EMA, CD34, vimentin/NA

Fotiadis [53]

55

M

Rectorrhagia

 

Sigmoid

S-M/CT: no metastasis

Post-Sur

Open/NA

(B)NA

Bhardwaj [54]

35

F

Tenesmus

2.3

Rectum

Mass/NA

Post-Sur

Open/NA

(A)GFAP/NA

Jacobson [55]

56

F

Asymptomatic

1.7

Sigmoid

S-M/NA

Post-Sur

Open/NA

(A)mitosis < 1/10

Maciejewski [56]

67

F

Abdominal pain

8

Rectum

S-M/US: large exophytic mass

Post-Sur

Open wedge/NA

(A)vimentin/NA

Matsushita [57]

79

M

NA

 

Transverse

S-M

Biopsy

Endoscopy/NA

NA

Horio [58]

66

M

FOB

3

Sigmoid

S-M

Post-Sur

Open/NA

Vimentin/NA

Sasatomi [59]

68

F

Rectorrhagia

4.7

Sigmoid

S-M/CT: mass

Post-Sur

Open/−

NA

Prévot [60]

74

M

NA

2

Right

NA

Post-Sur

Open/NA

Vimentin, NSE/NA

Tomozawa [61]

66

M

Asymptomatic

3.5

Right

Polypoid mass/CT: no enlarged LN

Biopsy

Open/NA

(A,B)vimentin/mitosis < 1/80

Skopelitou [62]

69

F

Rectorrhagia

3.5

Left

Polypoid mass/barium enema: obstruction

NA

Open/NA

GFAP, leu7/mitosis < 3/10

Kakizoe [63]

72

M

Asymptomatic

1.5

Rectum

S-M/NA

Post-Sur

Transanal μ/NA

(A)NA

Murakami [64]

75

M

Asymptomatic

2.2

Rectum

Ulcerated S-M/NA

Biopsy

Transanal/NA

NA

Sugimura [65]

14

M

Melena

 

Sigmoid

NA/barium enema: mass, CT: mass of soft tissue

Post-Sur

Open/NA

(A)vimentin/NA

Abe [66]

2

52

M

Protruding mass

1.5

Rectum

S-M

Biopsy

Transanal/NA

(A)NA

52

F

Rectal discomfort

4.5

Rectum

Polyp

Biopsy

Transanal/NA

(B)NA

Schwartz [67]

18

F

Abdominal girth

28

Sigmoid

NA

Post-Sur

Open/NA

(A)NA (malignant)

Cleveland [68]

60

F

Abdominal girth

20

Transverse

NA/abdominal X-ray: large mass aortogram

Post-Sur

Open/NA

NA

Bodner [69]

63

F

Constipation

 

Rectum

Recurrence, malignant transformation

Biopsy

Abdominal

Malignant

Wang CL [70]

77

F

NA

2.4

Cecum

NA/CT: well circumscribed, low homogenous enhancement FDG PET: hyper

Biopsy

Open/NA

(A,B)NA

Catania [71]

41

M

Tenesmus

8

Rectum

NA/heterogenous large mass

Post-surg

Open/−

c-Kit/NA Malignant

Present case

70

F

Asymptomatic

2

Cecum

S-M/CT: well circumscribed, homogenous enhancement, FDG PET: hypo, Octreo PET: hypo

Post-Sur

Openwedge/−

< 1/10

  1. S-M submucosal mass, S-polyp submucosal polyp, NA not available, − negative
  2. aAssociated with abdominal pain
  3. bEnucleation