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Table 1 Schwannomas of the colon and rectum: clinical and histopathologic characteristics of published case reports

From: Schwannoma of the colon and rectum: a systematic literature review

Study Age G Symptoms S Location Colonoscopy and imaging Diagnosis Surgery/LN (Antonini) S-100 +/mitosis
Tsunoda [1] 67 F FOB 3 Transverse Ulcerated S-M/ CT: well circumscribed, homogenous enhancement, EUS: hypo-echoic S-M Post-Sur Open/− NSE/MIB-1 low
Nonose [2] 71 F Tenesmus 3 Sigmoid Ulcerated S-polyp Biopsy Lap/− (A)Ki67 < 5%
Miettinem [4]
20
82 M NA 0.5 Rectum S-M/NA Biopsy Endoscopy/NA Mitosis 0/50
30 F FOB 1.5 Sigmoid S-M/NA Biopsy Endoscopy/NA Mitosis 2/50
83 M NA 2.3 Cecum NA Post-Sur Open/NA Mitosis 1/50
64 F Asymptomatic 2.5 Transverse NA Post-Sur Open/NA Mitosis 1/50
62 M Rectorrhagia 2.5 Left NA Post-Sur Open/NA Mitosis 0/50
65 M Asymptomatic 2.8 Cecum Cecal mass/NA Post-Sur Open/NA Mitosis 0/50
80 F NA 3 Sigmoid S-polyp/NA Post-Sur Open/NA Mitosis 1/50
71 F Rectorrhagia 3 Cecum NA Post-Sur Open/NA Mitosis 0/50
58 M Rectorrhagia 3 Transverse NA Biopsy Open/NA Mitosis 0/50
57 F Rectorrhagia 3 Sigmoid S-M/NA Post-Sur Open/NA Mitosis 1/50
84 F Asymptomatic 3.9 Cecum NA Biopsy Openb/NA Mitosis 0/50
87 M NA 4 NA NA Post-Sur NA Mitosis 5/50
75 F Constipation 4 Transverse S-M/NA Post-Sur Open/NA Mitosis 1/50
18 F Intussusception 5 Cecum S-M/NA Post-Sur Open/NA Mitosis 3/50
72 M NA 5.5 Cecum S-M/NA Post-Sur Open/NA Mitosis 0/50
55 M NA 0.7 Sigmoid S-M/NA Post-Sur Open/NA Mitosis 0/50
58 F NA 0.8 Sigmoid NA Post-Sur Open/NA Mitosis 0/50
72 M Weight lossa 1 Sigmoid S-polyp/NA Biopsy Endoscopy/NA Mitosis 0/50
61 F Ulcer symptoms 5 Sigmoid NA Post-Sur Open/NA Mitosis 0/50
23 F Asymptomatic 5.5 Sigmoid NA Post-Sur Open/NA Mitosis 1/50
Barbeiro [5] 49 F Asymptomatic 3 Right S-M/CT: well circumscribed, homogenous enhancement Post-Sur Open/− Low mitosis
Jung [6] 59 F Rectorrhagia 4.8 Sigmoid Fungating mass/CT: enlarged LN, FDG-PET: Hyper Post-Sur Open/− Mitosis < 1/10
Park [7]
2
52 F NA 1.3 Right S-M/CT: well circumscribed, homogenous enhancement Post-Sur Lap/NA NA
59 F Asymptomatic 1.5 Left S-M/CT: well circumscribed Post-Sur Lap/NA NA
Hornick [8] 48 M NA 5 NA NA NA NA NA
Akgul [9] 57 F Tenesmus 6.5 Rectum S-M/ CT: isodense + central necrosis Post-Sur Open/NA NA
Wang [10] 62 F Rectorrhagiaa 4 Right S-polyp/CT: well circumscribed, homogenous low enhancement Post-Sur Open/NA (A) Ki-67 < 3%
Tashiro [11] 64 F Asymptomatic 5 Right S-M/CT: well circumscribed, homogenous enhancement Post-Sur Lap/− MIB-1 < 5%
Suzuki [12] 70 F Asymptomatic 18 Rectum S-M/ MRI: hypo T1- hyper T2, EUS: hypo-echoic S-M Post-Sur Transanal μ/NA < 1/10
Bugiantella [13] 65 M FOB 2.5 Sigmoid S-M/ EUS: hypo-echoic S-M Post-Sur Lap/− Vimentin/Ki-67 < 2%
De Mesquita [14] 79 F Weight lossa 10 Cecum NA/CT: well circumscribed, homogenous low enhancement Post-Sur Open/NA Vimentin/NA
Vasilakaki [15] 68 M Rectorrhagia 4 Right S-M/NA Post-Sur Open/− NA
Kanneganti [16] 35 F Melenaa 4 Cecum Ulcerated S-M/CT: mass Post-Sur Open/NA low
Goh [17]
2
54 F Abdominal pain 3 Right Obstructing mass/NA Post-Sur Open/NA NA
41 F Rectorrhagia 2.9 Rectum S-M/EUS: S-M Post-Sur Transanal/NA NA
Inagawa [18]
2
73 F Rectorrhagiaa 3.5 Sigmoid Hard ulcerated S-M/CT: high density Post-Sur Open/NA (A)vimentin, GFAP/NA
44 M FOB 1 Cecum S-M/NA Biopsy Endoscopy/NA (A) vimentin, GFAP/NA
Turaihi [19] 61 F Rectorrhagia 4 Cecum S-M/CT: mass Post-Sur Lap/− NA
Uhr [20] 73 F Asymptomatic 3.1 Left S-M/CT: mass + enlarged LN Post-Sur Lap/NA (A)NA
Meeks [21] 95 F Obstruction 1 Appendix NA Post-Sur Open/NA NA
Terada [22] 52 M Asymptomatic 0.9 NA S-M Biopsy Endoscopy/NA NA
Çakir [23] 79 F Rectorrhagia 5 Sigmoid Rough ulcerated mass/CT: ulcerated mass Post-Sur Open/− Vimentin/Ki-67 < 5%
Dickson [24] 72 M Rectorrhagiaa   Cecum S-M/CT: mass Post-Sur Open/NA (A, B) NA
Tokuhara [25] 74 F FOB 3 Sigmoid S-M/EUS: hypo-echoic S-M Post-Sur Lap/NA (A)MIB-1 < 3%
Baskaran [26] 49 M FOB   Pancolic S-M/NA Biopsy Endoscopy/NA NA
Verdu-Fernandez [27] 67 M Asymptomatic 4.5 Left NA/CT: mass with enlarged LN, US: intussusception Post-Sur Open/NA CD68
Baek [28] 70 F Asymptomatic 2 Cecum Polyp/CT: polyp with low attenuation Post-Sur Lap/NA (A) CD34/ Ki-67 < 5%
Petrie [29] 25 M Bloody diarrheaa 4 Sigmoid Friable mucosa/CT: obstructing mass Post-Sur Open/NA (A)NA
Shelat [30] 63 F Anorexiaa   Rectum S-polyp/CT: polyp Post-Sur Open/− NA
Trivedi [31] 61 M NA 1.3 Sigmoid S-polyp/NA Post-Sur Endoscopy/NA CD34/MIB-1 < 2%
Kawaguchi [32] 77 F Tenesmus 1 Rectum S-M/EUS: hypoechoic, CT: mass Biopsy Endoscopy/NA (A) mitosis < 1/10
Tan [33] 63 F Early satiety 3 Rectum S-polyp/MRI: mass Post-Sur Open/ NA NA
Yang [34]
2
27 F Rectorrhagia 3 Rectum S-M/NA Post-Sur NA NA
53 M Asymptomatic 2 Sigmoid S-M/NA Post-Sur NA NA
Matsumoto [35] 59 F Asymptomatic 2 Cecum S-M/CT: well circumscribed, homogenous enhancement Post-Sur Lap wedge/NA Vimentin/ MIB-1 < 2%
Kim [36] 61 M Asymptomatic 1.8 Right Polypoid/CT: well circumscribed, homogenous enhancement Biopsy Lap/NA NA
Vijayasekaran [37] 75 F Asymptomatic 3.2 Rectum NA/EUS: S-M, CT: enlarged LN Post-Sur Open NA
Wu [38] 84 M NA   Rectum NA: FDG PET: hyper Post-Sur NA NA
Tedeschi [39] 80 M Rectorragia 4 Rectum S-polyp/CT: mass Post-Sur Open/NA (A)mitosis < 1/10
Tanaka [40] 70 F FOB   Left Ulcerated S-M/CT: well circumscribed, homogenous enhancement Post-Sur Open/NA (A,B)NA
Rocco [41] 67 F Asymptomatic 0.3 Left S-polyp/NA Biopsy Endoscopy/NA NA
Wani [42] 75 F Abdominal pain 5 Right S-polyp/NA Post-Sur Open/NA NA
Kienemud [43]
2
70 F Asymptomatic 0.7 Sigmoid S-M/NA Post-Sur Open/NA (B)NA
70 M Asymptomatic 1.3 Sigmoid S-polyp/NA Biopsy Endoscopy/NA (B)NA
Hsu KF [44] 88 F Constipation 3.5 Rectum S-M/EUS: hypoechoic, CT: no enlarged LN Post-Sur Transanal/NA (A,B)NA
Wilde [45] 68 F Explosive diarrhea, 1.5 Sigmoid NA Post-Sur Open/− (B)vimentin, GFAP/NA
Mysorekar [46] 33 M Abdominal pain 3.5 Right S-polyp Post-Sur Endoscopy/NA (A,B)NA
Lee [47] 32 F Constipation 1.4 Right S-polyp Biopsy Endoscopy/NA NA
Chetty [48] 43 F Asymptomatic   NA S-polyp Biopsy Endoscopy/NA HMB-45, Melan-A/NA
Brauman [49] 55 M Constipation 5 Right S-polyp/CT: mass with enlarged LN Post-Sur Open/NA Β-catenin, CD117/MIB-1 < 5%
Zippi [50] 72 M Abdominal pain 1.5 Rectum S-M/NA Biopsy Endoscopy/NA (A,B) NA
Hsu CT [51] 68 M Abdominal pain 3.5 Left S-M/ CT: well circumscribed, low homogenous enhancement, Post-Sur Open/NA NA
Emanuel [52] 48 M Rectorrhagia 4.9 Left Obstructing mass/CT: intussusception Post-Sur Open/NA (A)EMA, CD34, vimentin/NA
Fotiadis [53] 55 M Rectorrhagia   Sigmoid S-M/CT: no metastasis Post-Sur Open/NA (B)NA
Bhardwaj [54] 35 F Tenesmus 2.3 Rectum Mass/NA Post-Sur Open/NA (A)GFAP/NA
Jacobson [55] 56 F Asymptomatic 1.7 Sigmoid S-M/NA Post-Sur Open/NA (A)mitosis < 1/10
Maciejewski [56] 67 F Abdominal pain 8 Rectum S-M/US: large exophytic mass Post-Sur Open wedge/NA (A)vimentin/NA
Matsushita [57] 79 M NA   Transverse S-M Biopsy Endoscopy/NA NA
Horio [58] 66 M FOB 3 Sigmoid S-M Post-Sur Open/NA Vimentin/NA
Sasatomi [59] 68 F Rectorrhagia 4.7 Sigmoid S-M/CT: mass Post-Sur Open/− NA
Prévot [60] 74 M NA 2 Right NA Post-Sur Open/NA Vimentin, NSE/NA
Tomozawa [61] 66 M Asymptomatic 3.5 Right Polypoid mass/CT: no enlarged LN Biopsy Open/NA (A,B)vimentin/mitosis < 1/80
Skopelitou [62] 69 F Rectorrhagia 3.5 Left Polypoid mass/barium enema: obstruction NA Open/NA GFAP, leu7/mitosis < 3/10
Kakizoe [63] 72 M Asymptomatic 1.5 Rectum S-M/NA Post-Sur Transanal μ/NA (A)NA
Murakami [64] 75 M Asymptomatic 2.2 Rectum Ulcerated S-M/NA Biopsy Transanal/NA NA
Sugimura [65] 14 M Melena   Sigmoid NA/barium enema: mass, CT: mass of soft tissue Post-Sur Open/NA (A)vimentin/NA
Abe [66]
2
52 M Protruding mass 1.5 Rectum S-M Biopsy Transanal/NA (A)NA
52 F Rectal discomfort 4.5 Rectum Polyp Biopsy Transanal/NA (B)NA
Schwartz [67] 18 F Abdominal girth 28 Sigmoid NA Post-Sur Open/NA (A)NA (malignant)
Cleveland [68] 60 F Abdominal girth 20 Transverse NA/abdominal X-ray: large mass aortogram Post-Sur Open/NA NA
Bodner [69] 63 F Constipation   Rectum Recurrence, malignant transformation Biopsy Abdominal Malignant
Wang CL [70] 77 F NA 2.4 Cecum NA/CT: well circumscribed, low homogenous enhancement FDG PET: hyper Biopsy Open/NA (A,B)NA
Catania [71] 41 M Tenesmus 8 Rectum NA/heterogenous large mass Post-surg Open/− c-Kit/NA Malignant
Present case 70 F Asymptomatic 2 Cecum S-M/CT: well circumscribed, homogenous enhancement, FDG PET: hypo, Octreo PET: hypo Post-Sur Openwedge/− < 1/10
  1. S-M submucosal mass, S-polyp submucosal polyp, NA not available, − negative
  2. aAssociated with abdominal pain
  3. bEnucleation