Table 3 Association of EGFR expression intensity with clinico-pathologic parameters of head and neck squamous cell carcinoma
n (%) | P value | |||||
|---|---|---|---|---|---|---|
No intensity (n = 53) | Weak (n = 27) | Intermediate (n = 19) | Strong (n = 16) | Total (n = 115) | ||
Age group | ||||||
≤ 30 years | 1 (1.9) | 0 (0) | 1 (5.3) | 2 (12.5) | 4 (3.5) | 0.447 |
31–50 years | 27 (50.9) | 12 (44.4) | 10 (52.6) | 8 (50) | 57 (49.6) | |
> 50 years | 25 (47.2) | 15 (55.6) | 8 (42.1) | 6 (37.5) | 54 (47) | |
Gender | ||||||
Male | 37 (69.8) | 21 (77.8) | 16 (84.2) | 11 (68.8) | 85 (73.9) | 0.628 |
Female | 16 (30.2) | 6 (22.2) | 3 (15.9) | 5 (31.3) | 30 (26.1) | |
History of pan (n = 44) | ||||||
Yes | 11 (55) | 6 (66.7) | 5 (62.5) | 5 (71.4) | 27 (61.4) | 0.915 |
No | 9 (45) | 3 (33.3) | 3 (37.5) | 2 (28.6) | 17 (38.6) | |
History of smoking (n = 44) | ||||||
Yes | 4 (20) | 0 (0) | 0 (0) | 0 (0) | 4 (9.1) | 0.251 |
No | 16 (80) | 9 (100) | 8 (100) | 7 (100) | 40 (90.9) | |
History of alcohol (n = 44) | ||||||
Yes | 0 (0) | 1 (11.1) | 0 (0) | 0 (0) | 1 (2.3) | 0.545 |
No | 20 (100) | 8 (88.9) | 8 (100) | 7 (100) | 43 (97.7) | |
Location of tumor | ||||||
Oral cavity | 38 (71.7) | 19 (70.4) | 12 (63.2) | 10 (62.5) | 79 (68.7) | 0.814 |
Lip | 1 (1.9) | 1 (3.7) | 0 (0) | 1 (6.3) | 3 (2.6) | |
Tongue | 11 (20.8) | 6 (22.2) | 7 (36.8) | 5 (31.3) | 29 (25.2) | |
Soft palate | 3 (5.7) | 1 (3.7) | 0 (0) | 0 (0) | 4 (3.5) | |
Tumor stage | ||||||
T1 | 12 (22.6) | 7 (25.9) | 9 (47.4) | 3 (18.8) | 31 (27) | 0.003 |
T2 | 33 (62.3) | 13 (48.1) | 5 (26.3) | 3 (18.8) | 54 (47) | |
T3/T4 | 8 (15.1) | 7 (25.9) | 5 (26.3) | 10 (62.5) | 30 (26.1) | |
Tumor depth | ||||||
< 2 cm | 46 (86.8) | 22 (81.5) | 18 (94.7) | 12 (75) | 98 (85.2) | 0.377 |
≥ 2 cm | 7 (13.2) | 5 (18.5) | 1 (5.3) | 4 (25) | 17 (14.8) | |
Nodal stage | ||||||
No | 30 (56.6) | 14 (51.9) | 13 (68.4) | 6 (37.5) | 63 (54.8) | 0.433 |
N1 | 10 (18.9) | 3 (11.1) | 1 (5.3) | 3 (18.8) | 17 (14.8) | |
N2a | 0(0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
N2b | 12 (22.6) | 8 (29.6) | 5 (26.3) | 6 (37.5) | 31 (27) | |
N2c | 0 (0) | 2 (7.4) | 0 (0) | 1 (6.3) | 3 (2.6) | |
N3 | 1 (1.9) | 0 (0) | 0 (0) | 0 (0) | 1 (0.9) | |
Extranodal extention | ||||||
Not present | 43 (81.1) | 19 (70.4) | 14 (73.7) | 9 (56.3) | 85 (73.9) | 0.236 |
Present | 10 (18.9) | 8 (29.6) | 5 (26.3) | 7 (43.8) | 30 (26.1) | |
Histological subtypes | ||||||
Non-keratinizing | 8 (15.1) | 3 (11.1) | 3 (15.8) | 3 (18.8) | 17 (14.8) | 0.823 |
Keratinizing | 33 (62.3) | 15 (55.6) | 10 (52.6) | 7 (43.8) | 65 (56.5) | |
Non-keratinizing with maturation | 12 (22.6) | 9 (33.3) | 6 (31.6) | 6 (37.5) | 33 (28.7) | |
Histologic grade | ||||||
Grade-I | 19 (35.8) | 7 (25.9) | 4 (21.1) | 1 (6.3) | 31 (27) | 0.281 |
Grade-II | 27 (50.9) | 18 (66.7) | 13 (68.4) | 13 (81.3) | 71 (61.7) | |
Grade-III | 7 (13.2) | 2 (7.4) | 2 (10.5) | 2 (12.5) | 13 (11.3) | |
Lymphovascular invasion | ||||||
Not present | 52 (98.1) | 27 (100) | 19 (100) | 16 (100) | 114 (99.1) | 1.000 |
Present | 1 (1.9) | 0 (0) | 0 (0) | 0 (0) | 1 (0.9) | |
Perineural invasion | ||||||
Not present | 48 (90.6) | 23 (85.2) | 15 (78.9) | 13 (81.3) | 99 (86.1) | 0.493 |
Present | 5 (9.4) | 4 (14.8) | 4 (21.1) | 3 (18.8) | 16 (13.9) | |
Radiation (n = 45) | ||||||
Yes | 12 (60) | 7 (70) | 4 (50) | 2 (28.6) | 25 (55.6) | 0.366 |
No | 8 (40) | 3 (30) | 4 (50) | 5 (71.4) | 20 (44.4) | |
Chemotherapy (n = 45) | ||||||
Yes | 12 (60) | 6 (60) | 4 (50) | 2 (28.6) | 24 (53.3) | 0.513 |
No | 8 (40) | 4 (40) | 4 (50) | 5 (71.4) | 21 (46.7) | |