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Table 3 Association of EGFR expression intensity with clinico-pathologic parameters of head and neck squamous cell carcinoma

From: Immunohistochemical expression of epidermal growth factor receptor (EGFR) in South Asian head and neck squamous cell carcinoma: association with various risk factors and clinico-pathologic and prognostic parameters

  n (%) P value
No intensity (n = 53) Weak (n = 27) Intermediate (n = 19) Strong (n = 16) Total (n = 115)
Age group
 ≤ 30 years 1 (1.9) 0 (0) 1 (5.3) 2 (12.5) 4 (3.5) 0.447
 31–50 years 27 (50.9) 12 (44.4) 10 (52.6) 8 (50) 57 (49.6)
 > 50 years 25 (47.2) 15 (55.6) 8 (42.1) 6 (37.5) 54 (47)
Gender
 Male 37 (69.8) 21 (77.8) 16 (84.2) 11 (68.8) 85 (73.9) 0.628
 Female 16 (30.2) 6 (22.2) 3 (15.9) 5 (31.3) 30 (26.1)
History of pan (n = 44)
 Yes 11 (55) 6 (66.7) 5 (62.5) 5 (71.4) 27 (61.4) 0.915
 No 9 (45) 3 (33.3) 3 (37.5) 2 (28.6) 17 (38.6)
History of smoking (n = 44)
 Yes 4 (20) 0 (0) 0 (0) 0 (0) 4 (9.1) 0.251
 No 16 (80) 9 (100) 8 (100) 7 (100) 40 (90.9)
History of alcohol (n = 44)
 Yes 0 (0) 1 (11.1) 0 (0) 0 (0) 1 (2.3) 0.545
 No 20 (100) 8 (88.9) 8 (100) 7 (100) 43 (97.7)
Location of tumor
 Oral cavity 38 (71.7) 19 (70.4) 12 (63.2) 10 (62.5) 79 (68.7) 0.814
 Lip 1 (1.9) 1 (3.7) 0 (0) 1 (6.3) 3 (2.6)
 Tongue 11 (20.8) 6 (22.2) 7 (36.8) 5 (31.3) 29 (25.2)
 Soft palate 3 (5.7) 1 (3.7) 0 (0) 0 (0) 4 (3.5)
Tumor stage
 T1 12 (22.6) 7 (25.9) 9 (47.4) 3 (18.8) 31 (27) 0.003
 T2 33 (62.3) 13 (48.1) 5 (26.3) 3 (18.8) 54 (47)
 T3/T4 8 (15.1) 7 (25.9) 5 (26.3) 10 (62.5) 30 (26.1)
Tumor depth
 < 2 cm 46 (86.8) 22 (81.5) 18 (94.7) 12 (75) 98 (85.2) 0.377
 ≥ 2 cm 7 (13.2) 5 (18.5) 1 (5.3) 4 (25) 17 (14.8)
Nodal stage
 No 30 (56.6) 14 (51.9) 13 (68.4) 6 (37.5) 63 (54.8) 0.433
 N1 10 (18.9) 3 (11.1) 1 (5.3) 3 (18.8) 17 (14.8)
 N2a 0(0) 0 (0) 0 (0) 0 (0) 0 (0)
 N2b 12 (22.6) 8 (29.6) 5 (26.3) 6 (37.5) 31 (27)
 N2c 0 (0) 2 (7.4) 0 (0) 1 (6.3) 3 (2.6)
 N3 1 (1.9) 0 (0) 0 (0) 0 (0) 1 (0.9)
Extranodal extention
 Not present 43 (81.1) 19 (70.4) 14 (73.7) 9 (56.3) 85 (73.9) 0.236
 Present 10 (18.9) 8 (29.6) 5 (26.3) 7 (43.8) 30 (26.1)
Histological subtypes
 Non-keratinizing 8 (15.1) 3 (11.1) 3 (15.8) 3 (18.8) 17 (14.8) 0.823
 Keratinizing 33 (62.3) 15 (55.6) 10 (52.6) 7 (43.8) 65 (56.5)
 Non-keratinizing with maturation 12 (22.6) 9 (33.3) 6 (31.6) 6 (37.5) 33 (28.7)
Histologic grade
 Grade-I 19 (35.8) 7 (25.9) 4 (21.1) 1 (6.3) 31 (27) 0.281
 Grade-II 27 (50.9) 18 (66.7) 13 (68.4) 13 (81.3) 71 (61.7)
 Grade-III 7 (13.2) 2 (7.4) 2 (10.5) 2 (12.5) 13 (11.3)
Lymphovascular invasion
 Not present 52 (98.1) 27 (100) 19 (100) 16 (100) 114 (99.1) 1.000
 Present 1 (1.9) 0 (0) 0 (0) 0 (0) 1 (0.9)
Perineural invasion
 Not present 48 (90.6) 23 (85.2) 15 (78.9) 13 (81.3) 99 (86.1) 0.493
 Present 5 (9.4) 4 (14.8) 4 (21.1) 3 (18.8) 16 (13.9)
Radiation (n = 45)
 Yes 12 (60) 7 (70) 4 (50) 2 (28.6) 25 (55.6) 0.366
 No 8 (40) 3 (30) 4 (50) 5 (71.4) 20 (44.4)
Chemotherapy (n = 45)
 Yes 12 (60) 6 (60) 4 (50) 2 (28.6) 24 (53.3) 0.513
 No 8 (40) 4 (40) 4 (50) 5 (71.4) 21 (46.7)
  1. Chi-square test was applied
  2. P value ≤ 0.05 considered as significant