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Table 6 Cox models measured incidence densities and hazard ratio of overall survival

From: The diagnostic ureteroscopy before radical nephroureterectomy in upper urinary tract urothelial carcinoma is not associated with higher intravesical recurrence

 

N

Total person-year

Case

per 1000 person-year Incident rate

Crude HR (95% CI)

p-value

adjust HR (95% CI)

p-value

Main Effect

 URS- (Ref.)

2,634

6,941

531 (20.16%)

76.50

1 (Ref.)

 

1 (Ref.)

 

 URS+

3,079

8,195

568 (18.45%)

69.31

0.907 (0.81 – 1.02)

0.108

0.919 (0.82 – 1.04)

0.164

Baseline Patient Demographic Characteristics

 Gender

  Female (Ref.)

3,241

8,643

579 (17.86%)

66.99

1 (Ref.)

 

1 (Ref.)

 

  Male

2,472

6,493

520 (21.04%)

80.08

1.191 (1.06 – 1.34)

0.004*

1.225 (1.09 - 1.38)

0.001*

 Age Categories

  <65 yr(Ref.)

2,044

5,647

266 (13.01%)

47.10

1 (Ref.)

 

1 (Ref.)

 

  65-74 yr

2,094

5,546

410 (19.58%)

73.93

1.561 (1.34 - 1.82)

<0.001*

1.597 (1.36 - 1.87)

<0.001*

  >74yr

1,575

3,943

423 (26.86%)

107.28

2.245 (1.93 - 2.62)

<0.001*

2.290 (1.96 – 2.68)

<0.001*

 CCI score Categories

  0 (Ref.)

613

1,637

109 (17.78%)

66.57

1 (Ref.)

 

1 (Ref.)

 

  1

462

1,209

98 (21.21%)

81.03

1.211 (0.92 – 1.59)

0.169

1.134 (0.86 – 1.49)

0.372

  2+

4,638

12,289

892 (19.23%)

72.58

1.088 (0.89 – 1.33)

0.407

0.956 (0.78 – 1.18)

0.671

 Hypertension

  No (Ref.)

2,743

7,322

504 (18.37%)

68.83

1 (Ref.)

 

1 (Ref.)

 

  Yes

2,970

7,814

595 (20.03%)

76.15

1.103 (0.98 – 1.24)

0.104

0.992 (0.88 – 1.12)

0.896

 Hyperlipidemia

  No (Ref.)

4,509

11,883

908 (20.14%)

76.41

1 (Ref.)

 

1 (Ref.)

 

  Yes

1,204

3,253

191 (15.86%)

58.72

0.772 (0.66 – 0.90)

0.001*

0.777 (0.66 – 0.91)

0.002*

 DM

  No (Ref.)

4,399

11,682

825 (18.75%)

70.62

1 (Ref.)

 

1 (Ref.)

 

  Yes

1,314

3,454

274 (20.85%)

79.32

1.122 (0.98 - 1.29)

0.099

1.141 (0.99 - 1.32)

0.072

 ESRD

  No (Ref.)

4,562

12,134

862 (18.90%)

71.04

1 (Ref.)

 

1 (Ref.)

 

  Yes

1,151

3,002

237 (20.59%)

78.95

1.110 (0.96 - 1.28)

0.153

1.254 (1.08 - 1.46)

0.003*

  1. Crude HR relative hazard ratio, Adjusted HR adjusted hazard ratio controlling for age, gender, CCI score, Hypertension, Hyperlipidemia, diabetes and ESRD
  2. *p<0.05