| |
N
|
Total person-year
|
Case
|
per 1000 person-year Incident rate
|
Crude HR (95% CI)
|
p-value
|
adjust HR (95% CI)
|
p-value
|
|---|
|
Main Effect
|
|
URS- (Ref.)
|
2,634
|
6,941
|
531 (20.16%)
|
76.50
|
1 (Ref.)
| |
1 (Ref.)
| |
|
URS+
|
3,079
|
8,195
|
568 (18.45%)
|
69.31
|
0.907 (0.81 – 1.02)
|
0.108
|
0.919 (0.82 – 1.04)
|
0.164
|
|
Baseline Patient Demographic Characteristics
|
|
Gender
|
|
Female (Ref.)
|
3,241
|
8,643
|
579 (17.86%)
|
66.99
|
1 (Ref.)
| |
1 (Ref.)
| |
|
Male
|
2,472
|
6,493
|
520 (21.04%)
|
80.08
|
1.191 (1.06 – 1.34)
|
0.004*
|
1.225 (1.09 - 1.38)
|
0.001*
|
|
Age Categories
|
|
<65 yr(Ref.)
|
2,044
|
5,647
|
266 (13.01%)
|
47.10
|
1 (Ref.)
| |
1 (Ref.)
| |
|
65-74 yr
|
2,094
|
5,546
|
410 (19.58%)
|
73.93
|
1.561 (1.34 - 1.82)
|
<0.001*
|
1.597 (1.36 - 1.87)
|
<0.001*
|
|
>74yr
|
1,575
|
3,943
|
423 (26.86%)
|
107.28
|
2.245 (1.93 - 2.62)
|
<0.001*
|
2.290 (1.96 – 2.68)
|
<0.001*
|
|
CCI score Categories
|
|
0 (Ref.)
|
613
|
1,637
|
109 (17.78%)
|
66.57
|
1 (Ref.)
| |
1 (Ref.)
| |
|
1
|
462
|
1,209
|
98 (21.21%)
|
81.03
|
1.211 (0.92 – 1.59)
|
0.169
|
1.134 (0.86 – 1.49)
|
0.372
|
|
2+
|
4,638
|
12,289
|
892 (19.23%)
|
72.58
|
1.088 (0.89 – 1.33)
|
0.407
|
0.956 (0.78 – 1.18)
|
0.671
|
|
Hypertension
|
|
No (Ref.)
|
2,743
|
7,322
|
504 (18.37%)
|
68.83
|
1 (Ref.)
| |
1 (Ref.)
| |
|
Yes
|
2,970
|
7,814
|
595 (20.03%)
|
76.15
|
1.103 (0.98 – 1.24)
|
0.104
|
0.992 (0.88 – 1.12)
|
0.896
|
|
Hyperlipidemia
|
|
No (Ref.)
|
4,509
|
11,883
|
908 (20.14%)
|
76.41
|
1 (Ref.)
| |
1 (Ref.)
| |
|
Yes
|
1,204
|
3,253
|
191 (15.86%)
|
58.72
|
0.772 (0.66 – 0.90)
|
0.001*
|
0.777 (0.66 – 0.91)
|
0.002*
|
|
DM
|
|
No (Ref.)
|
4,399
|
11,682
|
825 (18.75%)
|
70.62
|
1 (Ref.)
| |
1 (Ref.)
| |
|
Yes
|
1,314
|
3,454
|
274 (20.85%)
|
79.32
|
1.122 (0.98 - 1.29)
|
0.099
|
1.141 (0.99 - 1.32)
|
0.072
|
|
ESRD
|
|
No (Ref.)
|
4,562
|
12,134
|
862 (18.90%)
|
71.04
|
1 (Ref.)
| |
1 (Ref.)
| |
|
Yes
|
1,151
|
3,002
|
237 (20.59%)
|
78.95
|
1.110 (0.96 - 1.28)
|
0.153
|
1.254 (1.08 - 1.46)
|
0.003*
|
- Crude HR relative hazard ratio, Adjusted HR adjusted hazard ratio controlling for age, gender, CCI score, Hypertension, Hyperlipidemia, diabetes and ESRD
- *p<0.05
