| N | Total person-year | Case | per 1000 person-year Incident rate | Crude HR (95% CI) | p-value | adjust HR (95% CI) | p-value |
---|---|---|---|---|---|---|---|---|
Main Effect | ||||||||
 URS- (Ref.) | 2,634 | 6,941 | 531 (20.16%) | 76.50 | 1 (Ref.) |  | 1 (Ref.) |  |
 URS+ | 3,079 | 8,195 | 568 (18.45%) | 69.31 | 0.907 (0.81 – 1.02) | 0.108 | 0.919 (0.82 – 1.04) | 0.164 |
Baseline Patient Demographic Characteristics | ||||||||
 Gender | ||||||||
  Female (Ref.) | 3,241 | 8,643 | 579 (17.86%) | 66.99 | 1 (Ref.) |  | 1 (Ref.) |  |
  Male | 2,472 | 6,493 | 520 (21.04%) | 80.08 | 1.191 (1.06 – 1.34) | 0.004* | 1.225 (1.09 - 1.38) | 0.001* |
 Age Categories | ||||||||
  <65 yr(Ref.) | 2,044 | 5,647 | 266 (13.01%) | 47.10 | 1 (Ref.) |  | 1 (Ref.) |  |
  65-74 yr | 2,094 | 5,546 | 410 (19.58%) | 73.93 | 1.561 (1.34 - 1.82) | <0.001* | 1.597 (1.36 - 1.87) | <0.001* |
  >74yr | 1,575 | 3,943 | 423 (26.86%) | 107.28 | 2.245 (1.93 - 2.62) | <0.001* | 2.290 (1.96 – 2.68) | <0.001* |
 CCI score Categories | ||||||||
  0 (Ref.) | 613 | 1,637 | 109 (17.78%) | 66.57 | 1 (Ref.) |  | 1 (Ref.) |  |
  1 | 462 | 1,209 | 98 (21.21%) | 81.03 | 1.211 (0.92 – 1.59) | 0.169 | 1.134 (0.86 – 1.49) | 0.372 |
  2+ | 4,638 | 12,289 | 892 (19.23%) | 72.58 | 1.088 (0.89 – 1.33) | 0.407 | 0.956 (0.78 – 1.18) | 0.671 |
 Hypertension | ||||||||
  No (Ref.) | 2,743 | 7,322 | 504 (18.37%) | 68.83 | 1 (Ref.) |  | 1 (Ref.) |  |
  Yes | 2,970 | 7,814 | 595 (20.03%) | 76.15 | 1.103 (0.98 – 1.24) | 0.104 | 0.992 (0.88 – 1.12) | 0.896 |
 Hyperlipidemia | ||||||||
  No (Ref.) | 4,509 | 11,883 | 908 (20.14%) | 76.41 | 1 (Ref.) |  | 1 (Ref.) |  |
  Yes | 1,204 | 3,253 | 191 (15.86%) | 58.72 | 0.772 (0.66 – 0.90) | 0.001* | 0.777 (0.66 – 0.91) | 0.002* |
 DM | ||||||||
  No (Ref.) | 4,399 | 11,682 | 825 (18.75%) | 70.62 | 1 (Ref.) |  | 1 (Ref.) |  |
  Yes | 1,314 | 3,454 | 274 (20.85%) | 79.32 | 1.122 (0.98 - 1.29) | 0.099 | 1.141 (0.99 - 1.32) | 0.072 |
 ESRD | ||||||||
  No (Ref.) | 4,562 | 12,134 | 862 (18.90%) | 71.04 | 1 (Ref.) |  | 1 (Ref.) |  |
  Yes | 1,151 | 3,002 | 237 (20.59%) | 78.95 | 1.110 (0.96 - 1.28) | 0.153 | 1.254 (1.08 - 1.46) | 0.003* |