The diagnostic ureteroscopy before radical nephroureterectomy in upper urinary tract urothelial carcinoma is not associated with higher intravesical recurrence

Table 6 Cox models measured incidence densities and hazard ratio of overall survival

	N	Total person-year	Case	per 1000 person-year Incident rate	Crude HR (95% CI)	p-value	adjust HR (95% CI)	p-value
Main Effect
URS- (Ref.)	2,634	6,941	531 (20.16%)	76.50	1 (Ref.)		1 (Ref.)
URS+	3,079	8,195	568 (18.45%)	69.31	0.907 (0.81 – 1.02)	0.108	0.919 (0.82 – 1.04)	0.164
Baseline Patient Demographic Characteristics
Gender
Female (Ref.)	3,241	8,643	579 (17.86%)	66.99	1 (Ref.)		1 (Ref.)
Male	2,472	6,493	520 (21.04%)	80.08	1.191 (1.06 – 1.34)	0.004*	1.225 (1.09 - 1.38)	0.001*
Age Categories
<65 yr(Ref.)	2,044	5,647	266 (13.01%)	47.10	1 (Ref.)		1 (Ref.)
65-74 yr	2,094	5,546	410 (19.58%)	73.93	1.561 (1.34 - 1.82)	<0.001*	1.597 (1.36 - 1.87)	<0.001*
>74yr	1,575	3,943	423 (26.86%)	107.28	2.245 (1.93 - 2.62)	<0.001*	2.290 (1.96 – 2.68)	<0.001*
CCI score Categories
0 (Ref.)	613	1,637	109 (17.78%)	66.57	1 (Ref.)		1 (Ref.)
1	462	1,209	98 (21.21%)	81.03	1.211 (0.92 – 1.59)	0.169	1.134 (0.86 – 1.49)	0.372
2+	4,638	12,289	892 (19.23%)	72.58	1.088 (0.89 – 1.33)	0.407	0.956 (0.78 – 1.18)	0.671
Hypertension
No (Ref.)	2,743	7,322	504 (18.37%)	68.83	1 (Ref.)		1 (Ref.)
Yes	2,970	7,814	595 (20.03%)	76.15	1.103 (0.98 – 1.24)	0.104	0.992 (0.88 – 1.12)	0.896
Hyperlipidemia
No (Ref.)	4,509	11,883	908 (20.14%)	76.41	1 (Ref.)		1 (Ref.)
Yes	1,204	3,253	191 (15.86%)	58.72	0.772 (0.66 – 0.90)	0.001*	0.777 (0.66 – 0.91)	0.002*
DM
No (Ref.)	4,399	11,682	825 (18.75%)	70.62	1 (Ref.)		1 (Ref.)
Yes	1,314	3,454	274 (20.85%)	79.32	1.122 (0.98 - 1.29)	0.099	1.141 (0.99 - 1.32)	0.072
ESRD
No (Ref.)	4,562	12,134	862 (18.90%)	71.04	1 (Ref.)		1 (Ref.)
Yes	1,151	3,002	237 (20.59%)	78.95	1.110 (0.96 - 1.28)	0.153	1.254 (1.08 - 1.46)	0.003*

Crude HR relative hazard ratio, Adjusted HR adjusted hazard ratio controlling for age, gender, CCI score, Hypertension, Hyperlipidemia, diabetes and ESRD
*p<0.05