Table 5 Cox models measured incidence densities and hazard ratio of intravesical recurrence outcome
| Â | N | Total person-year | Case | per 1000 person-year Incident rate | Crude HR (95% CI) | p-value | adjust HR (95% CI) | p-value |
|---|---|---|---|---|---|---|---|---|
Main Effect | ||||||||
 URS- (Ref.) | 2,634 | 6,243 | 392 (14.88%) | 62.79 | 1 (Ref.) |  | 1 (Ref.) |  |
 URS+ | 3,079 | 7,261 | 515 (16.73%) | 70.92 | 1.129 (0.99 - 1.29) | 0.069 | 1.136 (1.00 - 1.30) | 0.059 |
Baseline Patient Demographic Characteristics | ||||||||
 Gender | ||||||||
  Female (Ref.) | 3,241 | 7,798 | 464 (14.32%) | 59.50 | 1 (Ref.) |  | 1 (Ref.) |  |
  Male | 2,472 | 5,707 | 443 (17.92%) | 77.63 | 1.285 (1.13 - 1.46) | <0.001* | 1.293 (1.13 - 1.48) | <0.001* |
 Age Categories | ||||||||
  <65 yr(Ref.) | 2,044 | 5,028 | 332 (16.24%) | 66.03 | 1 (Ref.) |  | 1 (Ref.) |  |
  65-74 yr | 2,094 | 4,994 | 324 (15.47%) | 64.87 | 0.978 (0.84 - 1.14) | 0.771 | 0.994 (0.85 - 1.16) | 0.935 |
  >74yr | 1,575 | 3,482 | 251 (15.94%) | 72.09 | 1.067 (0.91 - 1.26) | 0.440 | 1.087 (0.92 - 1.29) | 0.334 |
 CCI score Categories | ||||||||
  0 (Ref.) | 613 | 1,467 | 95 (15.50%) | 64.75 | 1 (Ref.) |  | 1 (Ref.) |  |
  1 | 462 | 1,105 | 68 (14.72%) | 61.53 | 0.947 (0.69 - 1.29) | 0.731 | 0.932 (0.68 - 1.28) | 0.661 |
  2+ | 4,638 | 10,932 | 744 (16.04%) | 68.06 | 1.048 (0.85 - 1.30) | 0.667 | 0.917 (0.73 - 1.15) | 0.454 |
 Hypertension | ||||||||
  No (Ref.) | 2,743 | 6,560 | 437 (15.93%) | 66.61 | 1 (Ref.) |  | 1 (Ref.) |  |
  Yes | 2,970 | 6,944 | 470 (15.82%) | 67.68 | 1.009 (0.89 - 1.15) | 0.887 | 1.011 (0.88 - 1.16) | 0.870 |
 Hyperlipidemia | ||||||||
  No (Ref.) | 4,509 | 10,591 | 731 (16.21%) | 69.02 | 1 (Ref.) |  | 1 (Ref.) |  |
  Yes | 1,204 | 2,913 | 176 (14.62%) | 60.42 | 0.884 (0.75 - 1.04) | 0.141 | 0.883 (0.74 - 1.05) | 0.155 |
 DM | ||||||||
  No (Ref.) | 4,399 | 10,447 | 686 (15.59%) | 65.66 | 1 (Ref.) |  | 1 (Ref.) |  |
  Yes | 1,314 | 3,057 | 221 (16.82%) | 72.29 | 1.098 (0.94 - 1.28) | 0.227 | 1.152 (0.98 - 1.35) | 0.085 |
 ESRD | ||||||||
  No (Ref.) | 4,562 | 10,876 | 704 (15.43%) | 64.73 | 1 (Ref.) |  | 1 (Ref.) |  |
  Yes | 1,151 | 2,628 | 203 (17.64%) | 77.23 | 1.186 (1.01 - 1.39) | 0.033* | 1.221 (1.04 - 1.44) | 0.017* |