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Table 3 Metastasis-free survival and intravesical recurrence-free survival in univariate analysis and multivariate analysis by Cox proportional hazard model

From: The diagnostic ureteroscopy before radical nephroureterectomy in upper urinary tract urothelial carcinoma is not associated with higher intravesical recurrence

  Metastasis-free survival Intravesical recurrence-free survival
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
HR 95% CI p-value HR 95% CI p-value HR 95% CI p-value HR 95% CI p-value
Age, years 1.006 (0.990-1.022) 0.485 0.997 (0.980-1.014) 0.722 1.007 (0.991-1.023) 0.417 1.010 (0.993-1.027) 0.260
Gender (male vs female) 0.969 (0.690-1.360) 0.854 0.901 (0.598-1.357) 0.616 0.706 (0.506-0.987) 0.041* 0.721 (0.490-1.063) 0.099
Smoking (yes vs no) 1.025 (0.676-1.554) 0.908 0.850 (0.509-1.420) 0.534 1.244 (0.837-1.848) 0.281 1.068 (0.672-1.697) 0.782
Bladder cancer history (yes vs no) 0.985 (0.683-1.422) 0.936 0.969 (0.660-1.424) 0.874 4.850 (3.440-6.837) < 0.001* 5.085 (3.571-7.241) < 0.001*
Estimated GFR (<60 vs 60) 1.153 (0.802-1.658) 0.442 1.037 (0.702-1.532) 0.853 0.998 (0.703-1.417) 0.993 0.898 (0.623-1.293) 0.562
Operation method   0.711   0.854   0.527   0.991
 Open 1 (reference) - 1 (reference) - 1 (reference) - 1 (reference) -
 Laparoscopy 0.855 (0.582-1.258) 0.427 1.021 (0.681-1.531) 0.921 0.809 (0.549-1.192) 0.284 1.024 (0.677-1.550) 0.909
 Segmental resection 0.853 (0.313-2.321) 0.755 1.336 (0.486-3.668) 0.574 1.117 (0.454-2.747) 0.809 1.041 (0.413-2.624) 0.932
Multifocality (yes vs no) 1.952 (1.366-2.789) < 0.001* 1.474 (1.014-2.143) 0.042* 1.132 (0.765-1.676) 0.536 0.885 (0.587-1.334) 0.559
Grade (high vs low) 4.613 (2.419-8.796) < 0.001* 1.986 (0.961-4.105) 0.064 0.981 (0.670-1.437) 0.923 1.015 (0.643-1.601) 0.950
Pathologic T stage (pT2-4 vs pTa/Tis/T1) 5.183 (3.188-8.426) < 0.001* 2.983 (1.701-5.230) < 0.001* 1.042 (0.743-1.462) 0.810 1.178 (0.784-1.770) 0.430
Pathologic N stage (pN1-3 vs pN0/Nx) 8.895 (5.859-13.504) < 0.001* 5.786 (3.696-9.058) < 0.001* 0.977 (0.428-2.231) 0.977 0.930 (0.396-2.184) 0.867
URS biopsy (yes vs no) 0.963 (0.679-1.367) 0.834 1.046 (0.727-1.505) 0.808 1.093 (0.776-1.539) 0.611 1.113 (0.776-1.596) 0.560
  1. *p<0.05