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Table 2 Overall survival and disease-specific survival in univariate analysis and multivariate analysis by Cox proportional hazard model

From: The diagnostic ureteroscopy before radical nephroureterectomy in upper urinary tract urothelial carcinoma is not associated with higher intravesical recurrence

  Overall survival Disease-specific survival
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
HR 95% CI p-value HR 95% CI p-value HR 95% CI p-value HR 95% CI p-value
Age, years 1.019 (1.002-1.036) 0.027* 1.011(0.994-1.029) 0.201 1.012 (0.993-1.032) 0.223 1.004 (0.984-1.024) 0.723
Gender (male vs female) 0.963 (0.690-1.344) 0.825 0.909 (0.633-1.393) 0.755 0.881 (0.590-1.316) 0.536 0.870(0.534-1.415) 0.574
Smoking (yes vs no) 1.073 (0.716-1.608) 0.731 0.994 (0.611-1.617) 0.981 1.182 (0.734-1.903) 0.490 0.955 (0.525-1.736) 0.880
Bladder cancer history (yes vs no) 1.041 (0.730-1.486) 0.823 0.984 (0.675-1.435) 0.932 0.928 (0.597-1.441) 0.739 0.858 (0.536-1.374) 0.523
Estimated GFR (<60 vs 60) 1.240 (0.865-1.777) 0.241 0.934 (0.638-1.368) 0.727 1.252 (0.809-1.937) 0.312 0.982 (0.614-1.571) 0.941
Operation method   0.098   0.184   0.078   0.101
 Open 1 (reference) - 1 (reference) - 1 (reference) - 1 (reference) -
 Laparoscopy 0.632 (0.415-0.963) 0.033* 0.705 (0.453-1.096) 0.121 0.558 (0.333-0.937) 0.027* 0.615 (0.356-1.063) 0.082
 Segmental resection 1.028 (0.419-2.524) 0.952 1.459 (0.589-3.616) 0.414 1.141 (0.417-3.121) 0.798 1.723 (0.620-4.792) 0.297
Multifocality (yes vs no) 1.741 (1.220-2.486) 0.002* 1.319 (0.904-1.926) 0.151 1.847 (1.207-2.826) 0.005* 1.337 (0.851-2.101) 0.207
Grade (high vs low) 4.243 (2.339-7.696) < 0.001* 2.048 (1.023-4.100) 0.043* 8.450 (3.103-23.014) < 0.001* 2.459 (0.813-7.437) 0.111
Pathologic T stage (pT2-4 vs pTa/Tis/T1) 4.188 (2.695-6.507) < 0.001* 2.339 (1.378-3.972) 0.002* 10.691 (4.949-23.095) < 0.001* 5.242 (2.208-12.442) < 0.001*
Pathologic N stage (pN1-3 vs pN0/Nx) 9.720 (6.234-15.154) < 0.001* 6.342 (3.950-10.183) < 0.001* 13.236 (8.144-21.510) < 0.001* 8.084 (4.804-13.602) < 0.001*
URS biopsy (yes vs no) 0.946 (0.664-1.348) 0.760 1.069 (0.742-1.541) 0.720 1.085 (0.717-1.644) 0.699 1.260 (0.818-1.941) 0.294
  1. *p<0.05