Table 2 Overall survival and disease-specific survival in univariate analysis and multivariate analysis by Cox proportional hazard model

Age, years

1.019 (1.002-1.036)

1.011(0.994-1.029)

1.012 (0.993-1.032)

0.223

1.004 (0.984-1.024)

0.723

Gender (male vs female)

0.963 (0.690-1.344)

0.825

0.909 (0.633-1.393)

0.755

0.881 (0.590-1.316)

0.536

0.870(0.534-1.415)

0.574

Smoking (yes vs no)

1.073 (0.716-1.608)

0.731

0.994 (0.611-1.617)

0.981

1.182 (0.734-1.903)

0.490

0.955 (0.525-1.736)

0.880

Bladder cancer history (yes vs no)

1.041 (0.730-1.486)

0.823

0.984 (0.675-1.435)

0.932

0.928 (0.597-1.441)

0.739

0.858 (0.536-1.374)

0.523

Estimated GFR (<60 vs ≧60)

1.240 (0.865-1.777)

0.241

0.934 (0.638-1.368)

0.727

1.252 (0.809-1.937)

0.312

0.982 (0.614-1.571)

0.941

Operation method

0.098

0.184

0.078

0.101

 Open

1 (reference)

-

1 (reference)

-

1 (reference)

-

1 (reference)

-

 Laparoscopy

0.632 (0.415-0.963)

0.705 (0.453-1.096)

0.121

0.558 (0.333-0.937)

0.615 (0.356-1.063)

0.082

 Segmental resection

1.028 (0.419-2.524)

0.952

1.459 (0.589-3.616)

0.414

1.141 (0.417-3.121)

0.798

1.723 (0.620-4.792)

0.297

Multifocality (yes vs no)

1.741 (1.220-2.486)

1.319 (0.904-1.926)

0.151

1.847 (1.207-2.826)

1.337 (0.851-2.101)

0.207

Grade (high vs low)

4.243 (2.339-7.696)

< 0.001*

2.048 (1.023-4.100)

0.043*

8.450 (3.103-23.014)

< 0.001*

2.459 (0.813-7.437)

0.111

Pathologic T stage (pT2-4 vs pTa/Tis/T1)

4.188 (2.695-6.507)

< 0.001*

2.339 (1.378-3.972)

10.691 (4.949-23.095)

< 0.001*

5.242 (2.208-12.442)

Pathologic N stage (pN1-3 vs pN0/Nx)

9.720 (6.234-15.154)

< 0.001*

6.342 (3.950-10.183)

13.236 (8.144-21.510)

< 0.001*

8.084 (4.804-13.602)

URS biopsy (yes vs no)

0.946 (0.664-1.348)

0.760

1.069 (0.742-1.541)

0.720

1.085 (0.717-1.644)

0.699

1.260 (0.818-1.941)

0.294