Table 2 Treatment details
From: Carotid artery infusion via implantable catheters for squamous cell carcinoma of the tonsils
Stage (UICC) | I | III, IVA, IVB | IVC |
Number of cases | 1 | 9 | 1 |
Location | Tonsils | Tonsils | Primary tumor extending across the midline to the contralateral tonsils invading the entire soft palate three lung metastases and large lymph node metastases |
Technique | Intra-arterial infusion chemotherapy | Intra-arterial infusion chemotherapy | 1 cycle isolated thoracic perfusion 3 cycles intra-arterial infusion chemotherapy |
Number of cycles | 6 | 4–7 | 4 |
Chemotherapeutics per cycle | 30 mg cisplatin, 20 mg Adriamycin, 15 mg mitomycin, 500 mg 5-FU | 50 mg cisplatin, 30 mg Adriamycin, 15 mg mitomycin | 100 mg cisplatin, 60 mg Adriamycin, 20 mg mitomycin |
Infusion time | 7–10 min | 7–10 min | 10 min |
Chemofiltration | No | Venous chemofiltration with up to 4 l filtrate over 30 to 45 min for systemic detoxification | Venous chemofiltration with up to 4 l filtrate over 30 to 45 min for systemic detoxification |
Additional treatment | Aspirin 100 mg/day for 3 months. Repeated flushing of the port catheters is not necessary. | Aspirin 100 mg/day for 3 months. Repeated flushing of the port catheters is not necessary. | Aspirin 100 mg/day for 3 months. Repeated flushing of the port catheters is not necessary. |
Response | Complete response | No response, partial response or complete response depending on pretreatment, more details on table patient characteristics | Complete response |